基于近红外功能成像技术的大脑冲突监测功能研究

张晔; 王莉; 张静娜; 李鹏岳; 王倩楠; 桑林琼; 邱明国

doi:10.16016/j.1000-5404.202011128

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基于近红外功能成像技术的大脑冲突监测功能研究

神经科学 | 更新时间：2026-01-09

- 基于近红外功能成像技术的大脑冲突监测功能研究
- Application of functional near-infrared imaging for conflict monitoring: a preliminary study in 28 adults
- 第三军医大学学报 2021年43卷第7期页码：622-628
- 作者机构：
  
  400038 重庆，陆军军医大学（第三军医大学）生物医学工程与影像医学系医学图像学教研室
- 作者简介：
  
  [邱明国，E-mail: qiumingguo@yahoo.com QIU Mingguo, E-mail: qiumingguo@yahoo.com
- 基金信息：
  
  第三军医大学青年培育项目(2017XQN04);国家自然科学基金青年科学基金项目(81802253)
- DOI：10.16016/j.1000-5404.202011128
  中图分类号： R319;R338.25;R445.7
- 收稿：2020-11-13，
  
  修回：2020-12-13，
  
  纸质出版：2021-04-15
- 稿件说明：
移动端阅览
张晔, 王莉, 张静娜, 等. 基于近红外功能成像技术的大脑冲突监测功能研究[J]. 第三军医大学学报, 2021,43(7):622-628.

Ye ZHANG, Li WANG, Jingna ZHANG, et al. Application of functional near-infrared imaging for conflict monitoring: a preliminary study in 28 adults[J]. Journal of Third Military Medical University, 2021, 43(7): 622-628.
张晔, 王莉, 张静娜, 等. 基于近红外功能成像技术的大脑冲突监测功能研究[J]. 第三军医大学学报, 2021,43(7):622-628. DOI： 10.16016/j.1000-5404.202011128.

Ye ZHANG, Li WANG, Jingna ZHANG, et al. Application of functional near-infrared imaging for conflict monitoring: a preliminary study in 28 adults[J]. Journal of Third Military Medical University, 2021, 43(7): 622-628. DOI： 10.16016/j.1000-5404.202011128.

摘要

目的

运用近红外功能成像技术研究反应时不同的两组被试在冲突监测任务下大脑血氧反应的差异，探讨大脑冲突监测功能的神经机制。

方法

选取28名本校在校学生作为健康被试，其中男性16名，女性12名，年龄17~20（18.79±0.55）岁。运用近红外功能成像技术（functional near-infrared spectroscopy，fNIRS）采集被试Stroop任务下大脑的血氧浓度变化量。根据他们在Stroop任务中的反应时分为快组和慢组，每组14名。通过nirsLAB软件进行数据分析，对比两组被试大脑血氧反应的差异，并计算被试行为学指标与其大脑血氧浓度变化的相关关系。

结果

Stroop任务主要激活的脑区位于双侧背外侧前额叶（dorsolateral prefrontal cortex

DLPFC）和额极区。相比慢组，Stroop任务下快组的脱氧血红蛋白（Hb）浓度变化显著降低（

0.05），主要位于左侧DLPFC和额极区。同时，Ch4通道Hb的浓度变化值与被试反应时呈现正相关关系(

=0.422 3

=0.025 2)。

结论

实验结果验证了DLPFC在冲突监测功能中的核心作用，同时发现左侧额极区的Hb浓度变化可以作为反映大脑冲突监测功能的重要指标。

Abstract

Objective

To study the difference of cerebral blood oxygen response of subjects with different reaction speed under conflict task with the aid of functional near-infrared spectroscopy (fNIRS) in order to explore the neural mechanism of conflict monitoring.

Methods

Twenty-eight healthy students from our university were recruited as the subjects. They were 16 males and 12 females

at an age of 17~20 (18.79±0.55) years. The changes of blood oxygen concentration in the brain of these subjects during Stroop task were collected by fNIRS. According to their response time in Stroop task

they were assigned into fast group and slow group

with 14 students in each group. The data were analyzed by nirsLAB software to compare the changes of the relative concentration of oxygenated hemoglobin (HbO

) and the relative concentration of deoxygenated hemoglobin (Hb) between the 2 groups

and the correlation between the behavioral indexes and the changes of cerebral blood oxygen concentration was analyzed.

Results

Stroop task mainly activated bilateral dorsolateral prefrontal cortex (DLPFC) and frontal polar region. Compared with the slow group

the relative concentration of Hb was decreased significantly in the fast group under Stroop task

mainly located in the left DLPFC and frontal polar region (

0.05). Also

the relative concentration of Hb in Ch4 channel was positively correlated with the reaction time(

=0.422 3

=0.025 2).

Conclusion

Our results verify the core role of DLPFC in conflict monitoring

and find that the relative change of Hb concentration in the left frontal polar region can be regarded as an important indicator to reflect the conflict monitoring of the subjects.

关键词

Keywords

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