消化道神经内分泌肿瘤不同手术方式疗效比较及预后分析

姚幸雨; 陈文生

doi:10.16016/j.1000-5404.202011029

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消化道神经内分泌肿瘤不同手术方式疗效比较及预后分析

临床医学 | 更新时间：2026-01-09

- 消化道神经内分泌肿瘤不同手术方式疗效比较及预后分析
- Different surgical methods for gastrointestinal neuroendocrine tumors: comparison on efficacy and prognosis
- 第三军医大学学报 2021年43卷第6期页码：522-528
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.202011029
  中图分类号：
- 收稿：2020-11-03，
  
  纸质出版：2021-03-30
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姚幸雨, 陈文生. 消化道神经内分泌肿瘤不同手术方式疗效比较及预后分析[J]. 第三军医大学学报, 2021,43(6):522-528.

Xingyu YAO, Wensheng CHEN. Different surgical methods for gastrointestinal neuroendocrine tumors: comparison on efficacy and prognosis[J]. Journal of Third Military Medical University, 2021, 43(6): 522-528.
姚幸雨, 陈文生. 消化道神经内分泌肿瘤不同手术方式疗效比较及预后分析[J]. 第三军医大学学报, 2021,43(6):522-528. DOI： 10.16016/j.1000-5404.202011029.

Xingyu YAO, Wensheng CHEN. Different surgical methods for gastrointestinal neuroendocrine tumors: comparison on efficacy and prognosis[J]. Journal of Third Military Medical University, 2021, 43(6): 522-528. DOI： 10.16016/j.1000-5404.202011029.

摘要

Abstract

Objective

To investigate the related risk factors affecting postoperative recurrence and recurrent metastasis in the patients with gastrointestinal neuroendocrine tumors (GI-NETs)

and compare the therapeutic efficacy of different surgical methods as well as their impacts on prognosis.

Methods

The clinical data of 153 GI-NETs patients treated in our hospital from January 2010 to December 2019 were collected and retrospectively analyzed. The clinical characteristics and 5-year recurrence and metastasis rates were analyzed and calculated

and the prognostic factors and survival analysis was subsequently performed. In addition

the therapeutic efficacy was evaluated and compared between the endoscopic surgery and conventional surgery.

Results

Among the 153 GI-NETs patients

90 were males (58.82%) and 63 females (41.18%). According to the 2010 WHO NETs classification

114 cases (74.51%) were in G1 phases

25 (16.34%) in G2 phases and 14 (9.15%) in G3 phases. And 112 patients (73.20%) underwent endoscopic surgery and 41 (26.80%) received conventional surgery. There were 26 cases (16.99%) experiencing recurrence and metastasis within 5 years

with the percentages of 1.31%

3.92%

3.27% and 8.50%

respectively in the duodenum

esophagus

stomach and rectum. The rates of recurrence and metastasis were 3.92% and 13.07% respectively in the endoscopic surgery and conventional surgery. Log-rank test results indicated that there were statistical differences in the recurrence and metastasis of GI-NETs among different ages

tumor sites

tumor sizes

pathological grades

and surgical methods (

0.05). Multivariate Cox regression analysis showed that tumor size

pathological grade

and presence of tumor in the margin were independent risk factors affecting postoperative recurrence and metastasis (

0.05)

and the la

rger the tumor size and the higher the pathological grade

the higher the risks were. No statistical differences were seen in the recurrence and metastasis rates in the patients with G1 or G2 phase GI-NETs less than 2 cm

regardless of the surgery methods they received (

0.05).

Conclusion

Tumor size

pathological grade and presence of tumor in the margin are independent risk factors for postoperative recurrence and metastasis. GI-NETs in G1 and G2 phases less than 2 cm can be resected under endoscopy.

关键词

Keywords

references

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