Del Nido液对成人体外循环心脏手术心肌保护的影响: Meta分析

徐旭; 王玮璠; 于敏; 李勇男

doi:10.16016/j.1000-5404.202010151

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Del Nido液对成人体外循环心脏手术心肌保护的影响: Meta分析

临床医学 | 更新时间：2026-01-09

- Del Nido液对成人体外循环心脏手术心肌保护的影响: Meta分析
- Effect of Del Nido cardioplegia solution on myocardial protection in adult cardiac surgery under cardiopulmonary bypass: a Meta-analysis
- 第三军医大学学报 2021年43卷第8期页码：747-754
- 作者机构：
  
  730030 兰州，兰州大学第二医院心脏外科
- 作者简介：
  
  [李勇男，E-mail: lyngyq2006@foxmail.com LI Yongnan, E-mail: lyngyq2006@foxmail.com
- 基金信息：
- DOI：10.16016/j.1000-5404.202010151
  中图分类号： R654.1;R654.2;R944.1
- 收稿：2020-10-22，
  
  修回：2021-01-12，
  
  纸质出版：2021-04-30
- 稿件说明：
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徐旭, 王玮璠, 于敏, 等. Del Nido液对成人体外循环心脏手术心肌保护的影响: Meta分析[J]. 第三军医大学学报, 2021,43(8):747-754.

Xu XU, Weifan WANG, Min YU, et al. Effect of Del Nido cardioplegia solution on myocardial protection in adult cardiac surgery under cardiopulmonary bypass: a Meta-analysis[J]. Journal of Third Military Medical University, 2021, 43(8): 747-754.
徐旭, 王玮璠, 于敏, 等. Del Nido液对成人体外循环心脏手术心肌保护的影响: Meta分析[J]. 第三军医大学学报, 2021,43(8):747-754. DOI： 10.16016/j.1000-5404.202010151.

Xu XU, Weifan WANG, Min YU, et al. Effect of Del Nido cardioplegia solution on myocardial protection in adult cardiac surgery under cardiopulmonary bypass: a Meta-analysis[J]. Journal of Third Military Medical University, 2021, 43(8): 747-754. DOI： 10.16016/j.1000-5404.202010151.

摘要

目的

比较Del Nido液和常规心脏停搏液在成人患者中的应用效果。

方法

通过对PubMed、EMbase、The Cochrane Library、国际临床试验注册平台(ICTRP)、中国生物医学文献数据库(CBM)、清华同方(CNKI)、万方和维普(VIP)数据库进行系统检索相关文献，共纳入10项研究进行系统评价。

结果

研究显示应用Del Nido液组体外循环时间和阻断时间明显短于常规心脏停搏液组(MD：-7.32，95%

：-13.72~-0.92，

=0.03；MD：-5.63，95 %

：-9.70~-1.55，

=0.007)。术中Del Nido液组停搏液灌注量和血糖水平均低于对照组(MD：-555.34，95 %

：-784.02~-326.65，

0.000 01；MD：-61.17，95%

：-78.43~-43.91，

0.000 01)。应用Del Nido液的患者，ICU停留时间显著缩短(MD：-0.50，95%

：-0.85~-0.15，

0.005)。两组在心肌酶、术后心脏支持、机械通气时间、房颤发生率、住院时间和死亡率等方面无统计学差异。

结论

在成人心脏手术中的心肌保护中，相对于常规心脏停搏液，使用Del Nido液在能明显缩短体外循环时间和阻断主动脉时间的同时，达到与其相近的短期临床效果。

Abstract

Objective

To compare the efficacy of Del Nido cardioplegia solution and conventional cardioplegia in adult patients.

Methods

Systematic searches were performed to identify related studies using PubMed

EMbase

Cochrane Library

International Clinical Trials Registry Platform (ICTRP)

Chinese Biomedical Databases (CBM)

China National Knowledge Infrastructure Database (CNKI)

Wanfan Database and China Science and Technology Periodical Database (VIP). After testing for heterogeneity of all the eligible studies

a total of 10 studies were included.

Results

Cardiopulmonary bypass and cross-clamp time were significantly shorter in the Del Nido group than conventional cardioplegia group [mean difference (MD):-7.32

95%

:-13.72~-0.92

=0.03; MD:-5.63

95%

: -9.70~-1.55

=0.007

]

. During the operation

cardioplegia volume and blood glucose level were lower in the Del Nido group (MD: -555.34

95%

: -784.02~-326.65

0.000 01; MD: -61.17

95%

: -78.43~-43.91

0.000 01). The patients of the Del Nido group had significantly shorter length of intensive care unit stay than those of the other group (MD: -0.50

95%

: -0.85~-0.15

0.005). There were no statistical differences in myocardial enzymes

postoperative inotropic support

ventilation time

atrial fibrillation

hospital

and mortality between the 2 groups.

Conclusion

Del Nido cardioplegia solution is superior to the conventional one in shortening the cardiopulmonary bypass time and block the aorta time

but yielding similar short-term clinical outcomes for adult cardiac surgery.

关键词

Keywords

references

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