DNA修复基因APE1 Asp148Glu多态性与中国西南地区女性宫颈癌风险及预后相关

许文婧; 张诗珩; 王东

doi:10.16016/j.1000-5404.202010128

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DNA修复基因APE1 Asp148Glu多态性与中国西南地区女性宫颈癌风险及预后相关

临床医学 | 更新时间：2026-01-09

- DNA修复基因APE1 Asp148Glu多态性与中国西南地区女性宫颈癌风险及预后相关
- Polymorphism of DNA repair gene APE1 (Asp148Glu) is associated with risk and prognosis of cervical cancer in women of Southwest China
- 第三军医大学学报 2021年43卷第5期页码：418-424
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金面上项目(30670628);国家自然科学基金面上项目(30801367)
- DOI：10.16016/j.1000-5404.202010128
  中图分类号：
- 收稿：2020-10-20，
  
  纸质出版：2021-03-15
- 稿件说明：
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许文婧, 张诗珩, 王东. DNA修复基因APE1 Asp148Glu多态性与中国西南地区女性宫颈癌风险及预后相关[J]. 第三军医大学学报, 2021,43(5):418-424.

Wenjing XU, Shiheng ZHANG, Dong WANG. Polymorphism of DNA repair gene APE1 (Asp148Glu) is associated with risk and prognosis of cervical cancer in women of Southwest China[J]. Journal of Third Military Medical University, 2021, 43(5): 418-424.
许文婧, 张诗珩, 王东. DNA修复基因APE1 Asp148Glu多态性与中国西南地区女性宫颈癌风险及预后相关[J]. 第三军医大学学报, 2021,43(5):418-424. DOI： 10.16016/j.1000-5404.202010128.

Wenjing XU, Shiheng ZHANG, Dong WANG. Polymorphism of DNA repair gene APE1 (Asp148Glu) is associated with risk and prognosis of cervical cancer in women of Southwest China[J]. Journal of Third Military Medical University, 2021, 43(5): 418-424. DOI： 10.16016/j.1000-5404.202010128.

摘要

Abstract

Objective

To investigate whether the polymorphism of the DNA repair gene APE1(Asp148Glu) is associated with the risk and prognosis of cervical cancer in women of Southwest China.

Methods

We studied the clinical features of 290 woman with cervical cancer diagnosed in Daping hospital from January 2007 to July 2014. And another 290 healthy volunteers who took physical examination during the same period were recruited and served as normal control. The patients were followed up for the total survival. PCR-CTPP was used detect the genotype of APE1(Asp148Glu and -141T/G) in the patients and normal control.

Chi

-square test was applied to assess the distribution of individual clinical characteristics

and Hardy-Weinberg equilibrium was used to analyze the polymorphisms of these genes between the case and control. Multivariate logistic regression models were to assess the association of these polymorphisms with risk of cervical cancer. And Kaplan-Meier survival analysis was used to evaluate the relationship of overall survivals(OS) in different genotypes.

Results

The Glu/Glu genotype showed a lower risk of cervi

cal cancer(

=0.542

0.05) when compared with the APE1 Asp148 Asp/Asp genotype

especially for the individuals with following features: childbirth

=0.345

0.05)

menarche older than 14 years old(

=0.522

0.05)

non-menopause(

=0.324

0.05)

age of menopause ≥45 years old(

=0.495

0.05) or squamous carcinoma(

=0.597

0.05). And those carrying Glu genotype had a higher OS benefit than those carrying the APE1 Asp148 Asp genotypes(

=0.001). However

there was no significant association between the APE1 pro-141T/G polymorphism and risk of cervical cancer.

Conclusion

Homozygous APE1 148 Glu/ Glu genotype has a reduced risk and a better prognosis of cervical cancer.

关键词

Keywords

references

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