重庆市大学生PAEs低剂量暴露与精液参数、性激素水平的关联分析及安全限值比较

王艺蒙; 陈卿; 刘坤; 杨桓; 周妮娅; 孙磊; 邹鹏; 凌曦; 敖琳; 刘晋祎; 曹佳

doi:10.16016/j.1000-5404.202009207

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重庆市大学生PAEs低剂量暴露与精液参数、性激素水平的关联分析及安全限值比较

专题报道:生殖损害和不良妊娠结局的危险因素研究 | 更新时间：2026-01-09

- 重庆市大学生PAEs低剂量暴露与精液参数、性激素水平的关联分析及安全限值比较
- Analysis of semen parameters and sex hormones under low-dose PAEs exposure in Chongqing college students and comparison with reference dose
- 第三军医大学学报 2021年43卷第1期页码：31-37
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金重点项目(81630087);国家重点研发计划项目(2017YFC1002001)
- DOI：10.16016/j.1000-5404.202009207
  中图分类号：
- 收稿：2020-09-24，
  
  纸质出版：2021-01-15
- 稿件说明：
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王艺蒙, 陈卿, 刘坤, 等. 重庆市大学生PAEs低剂量暴露与精液参数、性激素水平的关联分析及安全限值比较[J]. 第三军医大学学报, 2021,43(1):31-37.

Yimeng WANG, Qing CHEN, Kun LIU, et al. Analysis of semen parameters and sex hormones under low-dose PAEs exposure in Chongqing college students and comparison with reference dose[J]. Journal of Third Military Medical University, 2021, 43(1): 31-37.
王艺蒙, 陈卿, 刘坤, 等. 重庆市大学生PAEs低剂量暴露与精液参数、性激素水平的关联分析及安全限值比较[J]. 第三军医大学学报, 2021,43(1):31-37. DOI： 10.16016/j.1000-5404.202009207.

Yimeng WANG, Qing CHEN, Kun LIU, et al. Analysis of semen parameters and sex hormones under low-dose PAEs exposure in Chongqing college students and comparison with reference dose[J]. Journal of Third Military Medical University, 2021, 43(1): 31-37. DOI： 10.16016/j.1000-5404.202009207.

摘要

Abstract

Objective

To analyze the associations of diethyl phthalate (DEP)

di-n-butyl phthalate (DnBP)

di(2-ethyl)hexyl phthalate (DEHP) and butyl benzyl phthalate (BBzP) [which have reference doses (RfD) in the plasticizer

phthalates (PAEs)] with semen parameters and sex hormone levels in the young male adults

and evaluate the safety of RfD.

Methods

A total of 796 subjects were sampled from our previously established cohort of the male reproductive health in Chongqing college students (MARHCS) study. The contents of PAEs metabolites were detected in the urine samples of the subjects to estimate the daily intake of PAEs. Optimal scaling regression analysis was used to test their associations of the contents with semen parameters and sex hormone levels. Joinpoint regression model was applied to explore whether there were inflection points in the above associations

and the results were compared with RfD.

Results

Except for the metabolite of BBzP (MBzP) below the detection limit in the most individua

the median daily intake of the other 3 PAEs was 0.1

1.0 and 4.3 μg/(kg·d) for DEP

DnBP and DEHP

which were all significantly lower than the corresponding RfD [800

100 and 20 μg/(kg·d)

]

and health guidance values [30

10 and 50 μg/(kg·d)

]

. The metabolite of DEP (MEP) was correlated with the progressive motility

normal sperm morphology

and testosterone level (

0.01); DnBP metabolite (MnBP) was correlated with normal sperm morphology (

0.05). Among the 4 metabolites of DEHP

MEHHP and MECPP were related to estrogen level (

0.05)

and MEOHP and MEHP to estrogen and progesterone levels (

0.01). But

inflection points were only observed in the correlations between DEHP and some parameters [threshold doses are 2.9~3.6 and 5.0~5.8 μg/(kg·d)

]

Conclusion

There are 12 kinds of associations of PAEs exposure with semen parameters and sex hormone levels in college students in Chongqing. PAEs

though below RfD

can still causes male reproductive damage.

关键词

Keywords

references

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