小肠胶囊内镜肠道准备的二甲硅油散推荐剂量：一项多中心随机对照研究

蒋立学; 白杨; 邓涛; 徐红; 杨强强; 钱凯; 杨雪丽; 金国花; 赵晓晏

doi:10.16016/j.1000-5404.202009008

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小肠胶囊内镜肠道准备的二甲硅油散推荐剂量：一项多中心随机对照研究

临床医学 | 更新时间：2026-01-09

- 小肠胶囊内镜肠道准备的二甲硅油散推荐剂量：一项多中心随机对照研究
- Optional dose of dimethicone in bowel preparation for small bowel capsule endoscopy: a multicenter randomized controlled trial
- 第三军医大学学报 2021年43卷第4期页码：311-317
- 作者机构：
  
  1.400037 重庆，陆军军医大学第二附属医院消化内科
  2.510515 广州，南方医科大学南方医院消化内科
  3.430060 武汉，武汉大学人民医院消化内科
  4.130021 长春，吉林大学第一医院胃肠内科内镜中心
- 作者简介：
  
  [ 赵晓晏，E-mail: zhaoxiaoyan2018@126.com ZHAO Xiaoyan, E-mail: zhaoxiaoyan2018@126.com
- 基金信息：
  
  国家卫计委公益性行业科研专项(201502013)
- DOI：10.16016/j.1000-5404.202009008
  中图分类号： R181.32;R574;R981.2
- 收稿：2020-09-02，
  
  修回：2020-11-25，
  
  纸质出版：2021-04-15
- 稿件说明：
移动端阅览
蒋立学, 白杨, 邓涛, 等. 小肠胶囊内镜肠道准备的二甲硅油散推荐剂量：一项多中心随机对照研究[J]. 第三军医大学学报, 2021,43(4):311-317.

Lixue JIANG, Yang BAI, Tao DENG, et al. Optional dose of dimethicone in bowel preparation for small bowel capsule endoscopy: a multicenter randomized controlled trial[J]. Journal of Third Military Medical University, 2021, 43(4): 311-317.
蒋立学, 白杨, 邓涛, 等. 小肠胶囊内镜肠道准备的二甲硅油散推荐剂量：一项多中心随机对照研究[J]. 第三军医大学学报, 2021,43(4):311-317. DOI： 10.16016/j.1000-5404.202009008.

Lixue JIANG, Yang BAI, Tao DENG, et al. Optional dose of dimethicone in bowel preparation for small bowel capsule endoscopy: a multicenter randomized controlled trial[J]. Journal of Third Military Medical University, 2021, 43(4): 311-317. DOI： 10.16016/j.1000-5404.202009008.

摘要

目的

研究不同剂量二甲硅油散对小肠胶囊内镜(small bowel capsule endoscopy

SBCE)肠道准备质量的影响，并探究二甲硅油散在SBCE肠道准备中的最佳剂量。

方法

采用多中心随机对照研究设计，自2016年5月至2019年1月纳入132名患者，平均分为3组，每组44人，所有患者在SBCE检查前6 h口服2 L复方聚乙二醇电解质散(polyethylene glycol

PEG)溶液清洁肠道，其中A组检查前30 min口服清水100 mL，B组检查前30 min口服浓度为2.5 g/100 mL二甲硅油散溶液100 mL，C组检查前30 min口服浓度为5 g/100 mL二甲硅油散溶液100 mL。主要评价指标为小肠气泡量(small bowel bubble quantity

SBBQ)、小肠有效图片率(small bowel valid picture ratio

SBVPR)、小肠清洁度(small bowel cleaning quality

SBCQ)，次要评价指标为胃气泡量(gastric bubble quantity

GBQ)、胃清洁度(gastric cleaning quality

GCQ)、全小肠检查完成率(completion rate

CR)、小肠疾病阳性检出率(diagnostic yield

DY)、胶囊通过小肠时间(small bowel transit time

SBTT)、胶囊通过胃时间(gastric transit time

GTT)。

结果

A组小肠近段、中段、远段气泡量均高于B组及C组(

0.05)，B组与C组间无统计学差异(

0.05)；A组近段、中段、远段小肠有效图片率均低于B组及C组(

0.05)，B组与C组间无统计学差异(

0.05)；A、B、C三组间小肠清洁度、胃气泡量、胃清洁度、全小肠检查完成率、小肠疾病阳性检出率、胶囊通过小肠时间及胶囊通过胃时间均无统计学差异(

0.05)。

结论

SBCE检查前服用二甲硅油散可有效消除小肠气泡，增加胶囊内镜下黏膜清晰辨别度，二甲硅油散的最佳剂量是2.5 g。

Abstract

Objective

To assess the effects of dimethicone at different doses in bowel preparation for small bowel capsule endoscopy (SBCE) and explore the optimal dose for the examination.

Methods

A multicenter randomized controlled trial (RCT) was carried out on 132 patients from 4 different institutions from May 2016 to January 2019. They were randomly divided into 3 groups

with 44 cases in each group. All of them were given 2 liters of polyethylene glycol (PEG) solution orally 6 h before procedure

and then in 30 min before examination

the patients were asked to drink 100 mL pure water

2.5 g and 5 g 100 mL dimethicone solution for those from group A

B and C

respectively. The primary evaluation indexes included small bowel bubble quantity (SBBQ)

small bowel valid picture ratio (SBVPR)

small bowel cleaning quality (SBCQ)

and the secondary evaluation indexes contained gastric bubble quantity (GBQ)

gastric cleaning quality (GCQ)

completion rate (CR)

diagnostic yield (DY)

and small bowel transit time (SBTT) and gastric transit time(GTT) of the capsule.

Results

The SBBQ of group A was higher than those of the other 2 groups in the proximal

middle and distal segments of small intestine (

0.05)

and there was no significant difference between group B and C (

0.05). Similar results were seen in the SBIRP in the 3 groups. No statistical significances were found in other indexes amon

g the 3 groups (

0.05).

Conclusion

Dimethicone treatment can efficiently decrease intraluminal bubbles and improve the visibility of small bowel mucosa for SBCE

and the optimal dose of dimethicone is 2.5 g.

关键词

Keywords

references

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