新生儿血清胆红素水平与定量脑电图相关性研究

李洁琼; 李颖; 李欣; 白璐; 薄涛

doi:10.16016/j.1000-5404.202007084

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新生儿血清胆红素水平与定量脑电图相关性研究

临床医学 | 更新时间：2026-01-09

- 新生儿血清胆红素水平与定量脑电图相关性研究
- Correlation of serum bilirubin with quantitative electroencephalographic parameters in neonatal infants
- 第三军医大学学报 2021年43卷第3期页码：271-275
- 作者机构：
  
  1.410011 长沙，中南大学湘雅三医院新生儿科
  2.410011 长沙，长沙市第一医院儿科
- 作者简介：
  
  [薄涛，E-mail: boily@yeah.net BO Tao, E-mail: boily@yeah.net
- 基金信息：
- DOI：10.16016/j.1000-5404.202007084
  中图分类号： R181.32;R722.17;R741.044
- 收稿：2020-07-20，
  
  修回：2020-10-09，
  
  纸质出版：2021-02-15
- 稿件说明：
移动端阅览
李洁琼, 李颖, 李欣, 等. 新生儿血清胆红素水平与定量脑电图相关性研究[J]. 第三军医大学学报, 2021,43(3):271-275.

Jieqiong LI, Ying LI, Xin LI, et al. Correlation of serum bilirubin with quantitative electroencephalographic parameters in neonatal infants[J]. Journal of Third Military Medical University, 2021, 43(3): 271-275.
李洁琼, 李颖, 李欣, 等. 新生儿血清胆红素水平与定量脑电图相关性研究[J]. 第三军医大学学报, 2021,43(3):271-275. DOI： 10.16016/j.1000-5404.202007084.

Jieqiong LI, Ying LI, Xin LI, et al. Correlation of serum bilirubin with quantitative electroencephalographic parameters in neonatal infants[J]. Journal of Third Military Medical University, 2021, 43(3): 271-275. DOI： 10.16016/j.1000-5404.202007084.

摘要

目的

分析新生儿血清总胆红素(total serum bilirubin

TSB)浓度对定量脑电图(quantitative electroencephalogram

qEEG)的影响，探讨二者之间的关联性。

方法

收集2019年1-12月期间入住中南大学湘雅三医院出生胎龄35~42周并行qEEG检查的新生儿临床资料，根据qEEG检查前24 h内所测患儿TSB将其分为3组，A组(TSB＜221 μmol/L)、B组(221 μmol/L≤TSB＜342 μmol/L)和C组(TSB≥342 μmol/L)，比较各组间qEEG参数的变化，并对TSB与qEEG参数进行相关性分析。

结果

符合纳入标准的病例共104例，A组56例，B组和C组各24例。在额区，3组之间总功率、频谱边缘频率(spectrum edge frequency，SEF)、各频带绝对功率及相对功率等差异无统计学意义；但C组的总功率较A组和B组均明显增高，差异有统计学意义(

0.05)。在颞区和枕区，3组之间SEF具有统计学差异(

0.05)，C组的SEF较A组和B组显著降低(

0.05)。在额区、颞区和枕区，SEF和TSB呈显著负相关(

0.05)。

结论

新生儿qEEG的SEF与TSB变化存在相关性，qEEG的SEF可能成为监测新生儿高胆红素血症对脑功能影响的工具。

Abstract

Objective

To determine the effect of serum bilirubin level on the parameters of quantitative electroencephalogram (qEEG) in neonates and investigate their correlation.

Methods

Clinical data of the neonatal infants (with a gestational age of 35~42 weeks) admitted to the Department of Neonatology

the Third Xiangya Hospital from January to December 2019 were collected and analyzed. According to the serum level of total serum bilirubin (TSB) in 24 h before qEEG

the children were divided into group A (< 221 μmol/L)

group B (221 ~342 μmol/L) and group C (≥342 μmol/L). The changes in qEEG parameters were compared among the 3 groups

and the correlation of the TSB level with the qEEG parameters were analyzed.

Results

There were 104 neonatal infants enrolled

including 56 in group A

24 in group B

and 24 in group C. In the frontal region

there were no statistical differences in the total spectral power

spectral edge frequency (SEF)

absolute power of frequency bands and relative power of frequency bands in the 3 groups. But the total spectral power in group C was significantly higher than that in the other 2 groups (

0.05). In the temporal region and occipital region

SEF differed significantly among the 3 groups (

0.05)

and the SEF in group C was significantly lower than that in the other 2 groups (

0.05). SEFs were negatively correlated with TSB in the frontal region

temporal region

and occipital region (

0.05).

Conclusion

In neonates

serum TSB level is correlated with SEF of qEEG

SEF might become an important indicator to monitor the effect of neonatal hyperbilirubinemia on brain function.

关键词

Keywords

references

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