血浆mtDNA水平与体外循环心脏术后炎症反应的关联性研究

范景秀; 胡佳; 郭应强; 康焰

doi:10.16016/j.1000-5404.202007081

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血浆mtDNA水平与体外循环心脏术后炎症反应的关联性研究

临床医学 | 更新时间：2026-01-09

- 血浆mtDNA水平与体外循环心脏术后炎症反应的关联性研究
- Association of plasma mtDNA level with cardiopulmonary bypass-related inflammation in ICU patients
- 第三军医大学学报 2020年42卷第24期页码：2403-2407
- 作者机构：
  
  1.610041 成都，四川大学华西医院心脏大血管外科
  2.610041 成都，四川大学华西医院重症医学科
- 作者简介：
  
  [康焰, E-mail: kangyan@scu.edu.cn KANG Yan, E-mail: kangyan@scu.edu.cn
- 基金信息：
  
  国家自然科学基金面上项目(81670327);四川省科技厅重点研发项目(2020YFS0163)
- DOI：10.16016/j.1000-5404.202007081
  中图分类号： R364.5;R446.11;R654.1
- 收稿：2020-07-08，
  
  修回：2020-08-10，
  
  纸质出版：2020-12-30
- 稿件说明：
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范景秀, 胡佳, 郭应强, 等. 血浆mtDNA水平与体外循环心脏术后炎症反应的关联性研究[J]. 第三军医大学学报, 2020,42(24):2403-2407.

Jingxiu FAN, Jia HU, Yingqiang GUO, et al. Association of plasma mtDNA level with cardiopulmonary bypass-related inflammation in ICU patients[J]. Journal of Third Military Medical University, 2020, 42(24): 2403-2407.
范景秀, 胡佳, 郭应强, 等. 血浆mtDNA水平与体外循环心脏术后炎症反应的关联性研究[J]. 第三军医大学学报, 2020,42(24):2403-2407. DOI： 10.16016/j.1000-5404.202007081.

Jingxiu FAN, Jia HU, Yingqiang GUO, et al. Association of plasma mtDNA level with cardiopulmonary bypass-related inflammation in ICU patients[J]. Journal of Third Military Medical University, 2020, 42(24): 2403-2407. DOI： 10.16016/j.1000-5404.202007081.

摘要

目的

探究体外循环心脏术后ICU患者血浆mtDNA水平与炎症细胞计数和炎症因子表达之间的潜在联系。

方法

2015年9月1日到2016年12月1日，华西医院心外科行体外循环心脏手术患者，返回ICU半小时内采集血常规、肝功和肾功、NT-proBNP、IL-6、CRP、PCT和mtDNA。规范完成检测和结果判定及录入，SPSS21.0进行统计分析。

结果

① 纳入患者962名，男性459名，女性503名。②血浆mtDNA水平对数值与体外循环心脏术后血小板活化程度对数值之间存在直线相关(

=0.102 7，

=0.002 8)。③血浆mtDNA水平平方根数值与体外循环心脏术后中性粒细胞绝对值平方根数值之间存在直线相关(

=0.106 9，

=0.0040)。④血浆mtDNA水平对数值与体外循环心脏术后IL-6对数值之间存在直线相关(

=0.0798，

=0.045 3)。

结论

血浆mtDNA水平与体外循环心脏术后早期患者的全身炎症反应密切相关。体外循环过程中活化炎症细胞可能是血浆mtDNA的释放来源。

Abstract

Objective

To explore the potential association of plasma mtDNA level with inflammatory cell counts and inflammatory factor levels in ICU patients after cardiac surgery under cardiopulmonary bypass (CPB).

Methods

From September 1

2015 to December 1

2016

all the patients who underwent cardiac surgery under CPB at our department of cardiovascular surgery were recruited in this study. Blood routine

liver and renal functions

and the levels of N-terminal brain natriuretic propeptide (NT-proBNP)

IL-6

C-reactive protein (CRP)

procalcitonin (PCT)

and mtDNA were tested and measured within half an hour after cardiac surgery according to the respective requirements. Statistical software SPSS 21.0 was used for statistical analysis.

Results

① A total of 962 patients were included in this study

including 459 males and 503 females. ② A linear correlation was observed between the logarithm of plasma mtDNA level and the logarithm of platelet activation after cardiac surgery under CPB (

=0.102 7

=0.002 8). ③The square root of the plasma mtDNA level had a linear correlation with the square root of the absolute neutrophil number after cardiac surgery under CPB (

=0.106 9

=0.004 0). ④There was a linear correlation between the logarithm of plasma mtDNA levels and the logarithm of IL-6 after cardiac surgery under CPB (

=0.079 8

=0.045 3).

Conclusion

Plasma mtDNA level is closely associated with systemic inflammatory responses in ICU post-CPB patients at early stage. Activation of inflammatory cells in the CPB process may be the source of plasma mtDNA release

关键词

Keywords

references

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