低谷蛋白大米(W0868)对小鼠营养状况及肾功能的影响

王梨名; 刘金凤; 陈佳; 罗佳; 汪晓月; 何娅妮; 蔡明玉

doi:10.16016/j.1000-5404.202007048

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低谷蛋白大米(W0868)对小鼠营养状况及肾功能的影响

基础医学 | 更新时间：2026-01-09

- 低谷蛋白大米(W0868)对小鼠营养状况及肾功能的影响
- Effects of low-gluten rice (W0868) feeding on nutritional status and renal function in mice
- 第三军医大学学报 2021年43卷第1期页码：68-74
- 作者机构：
- 作者简介：
- 基金信息：
  
  重庆市技术创新与应用示范项目(CSTC2018jscx-msybX0093);国家自然科学基金青年科学基金(81800646)
- DOI：10.16016/j.1000-5404.202007048
  中图分类号：
- 收稿：2020-07-07，
  
  纸质出版：2021-01-15
- 稿件说明：
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王梨名, 刘金凤, 陈佳, 等. 低谷蛋白大米(W0868)对小鼠营养状况及肾功能的影响[J]. 第三军医大学学报, 2021,43(1):68-74.

Liming WANG, Jinfeng LIU, Jia CHEN, et al. Effects of low-gluten rice (W0868) feeding on nutritional status and renal function in mice[J]. Journal of Third Military Medical University, 2021, 43(1): 68-74.
王梨名, 刘金凤, 陈佳, 等. 低谷蛋白大米(W0868)对小鼠营养状况及肾功能的影响[J]. 第三军医大学学报, 2021,43(1):68-74. DOI： 10.16016/j.1000-5404.202007048.

Liming WANG, Jinfeng LIU, Jia CHEN, et al. Effects of low-gluten rice (W0868) feeding on nutritional status and renal function in mice[J]. Journal of Third Military Medical University, 2021, 43(1): 68-74. DOI： 10.16016/j.1000-5404.202007048.

摘要

Abstract

Objective

To observe the effects of low-gluten rice feeding on nutrient metabolism and renal function in mice.

Methods

Thirty male C57/BL6 mice aged 6-8 weeks were randomly divided into 3 equal groups for dietary intervention with normal chow (control group)

common rice mixed at 1 :1 ratio with normal chow (normal rice group)

or low-gluten rice mixed at 1 :1 with normal chow (low-gluten rice group). Each mouse was given free access to food separately

and their food intake was monitored on a daily basis. Body weight of the mice was measured once a week during dietary intervention. Urine samples were collected at 4

and 12 weeks during the feeding

and serum and renal tissue samples were obtained at 12 weeks to assess the parameters related with the nutritional status (total protein

albumin

prealbumin

globulin

calcium

and phosphorus levels)

renal function (blood creatinine and urea nitrogen)

and the urine markers [urine creatinine

urine albumin/urinary creatinine ratio (ACR)

β-N-acetylglucosaminide (NAG)

and urine protein]. PAS staining was used for pathological examination of the renal tissues of the mice in the 3 groups.

Results

The average food intake or body weight of the mice did not differ significantly among the 3 groups during the dietary intervention. The nutritional status and the renal function at 12 weeks were similar among the 3 groups. The mice in low-gluten rice group showed a significantly lower level of total urine protein at 12 weeks and lower urine ACR and NAG levels at 4

8 and 12 weeks than those in the other two groups. None of the mice in the 3 groups showed obvious histopathological changes in the kidneys.

Conclusion

Low-gluten rice (W0868) diet can significantly reduce urine protein levels to protect the renal function in mice without causing adverse effect on the nutritional status.

关键词

Keywords

references

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