EVI1基因阳性的急性髓系白血病患者临床特点及其造血干细胞移植的疗效观察

蔺诗佳; 刘雨青; 姚浛; 朱丽丹; 赵伟; 陈婷; 向茜茜; 王路; 张曦; 孔佩艳

doi:10.16016/j.1000-5404.202006024

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EVI1基因阳性的急性髓系白血病患者临床特点及其造血干细胞移植的疗效观察

更新时间：2026-01-09

- EVI1基因阳性的急性髓系白血病患者临床特点及其造血干细胞移植的疗效观察
- Clinical characteristics of EVI1⁺ AML and clinical observation of hematopoietic stem cell transplantation on these patients
- 第三军医大学学报 2020年42卷第17期页码：1699-1705
- 作者机构：
- 作者简介：
- 基金信息：
  
  陆军军医大学科技创新能力提升专项临床医学科研人才项目(2019XLC3034)
- DOI：10.16016/j.1000-5404.202006024
  中图分类号：
- 收稿：2020-06-02，
  
  纸质出版：2020-09-15
- 稿件说明：
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蔺诗佳, 刘雨青, 姚浛, 等. EVI1基因阳性的急性髓系白血病患者临床特点及其造血干细胞移植的疗效观察[J]. 第三军医大学学报, 2020,42(17):1699-1705.

Shijia LIN, Yuqing LIU, Han YAO, et al. Clinical characteristics of EVI1⁺ AML and clinical observation of hematopoietic stem cell transplantation on these patients[J]. Journal of Third Military Medical University, 2020, 42(17): 1699-1705.
蔺诗佳, 刘雨青, 姚浛, 等. EVI1基因阳性的急性髓系白血病患者临床特点及其造血干细胞移植的疗效观察[J]. 第三军医大学学报, 2020,42(17):1699-1705. DOI： 10.16016/j.1000-5404.202006024.

Shijia LIN, Yuqing LIU, Han YAO, et al. Clinical characteristics of EVI1⁺ AML and clinical observation of hematopoietic stem cell transplantation on these patients[J]. Journal of Third Military Medical University, 2020, 42(17): 1699-1705. DOI： 10.16016/j.1000-5404.202006024.

摘要

Abstract

Objective

To investigate the clinical characteristics

treatment response

and prognosis of acute myeloid leukemia (AML) with high expression of EVI1 and the effectiveness of hematopoietic stem cell transplantation (HSCT).

Methods

A total of 7 subjects diagnosed with EVI1

AML in our center from January 2016 to May 2020 were enrolled in this study. They were 1 male and 6 females

and at a median age of 8 (3～49) years. The expression level of EVI1 gene was measured by nested PCR

analyzed together with morphological type

cytogenetics and molecular biology data of bone marrow. To characterize the clinical features of EVI1

AML and to observe the therapeutic effect of hematopoietic stem cell transplantation.

Results

The results of risk stratification showed that all these EVI1

AML patients were at high risk. By the end of follow-up on May 31

2020

2 patients relapsed during standard chemotherapy. For the 6 patients undergoing allogeneic HSCT (allo-HSCT)

5 achieved complete remission (CR) before transplantation

and the other 1 only achieved secondary CR after salvage transplantation. One patient relapsed during standard chemotherapy

did not receive transplantation

and died 10 months after diagnosis. All 6 patients who received allo-HSCT stayed in remission by the end of the study.

Conclusion

EVI1

AML patients have poor outcomes

and are at high risk of relapse

but achieve sound CR

with M4 and M5 more commonly. Allo-HSCT can significantly improve the prognosis of EVI1

AML patients.

关键词

Keywords

references

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