恶性血液病患者并发肛周组织感染相关因素Meta分析

陈小丽; 冯一梅; 孙恒蕊; 张曦; 孔佩艳; 杜欣

doi:10.16016/j.1000-5404.202005137

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恶性血液病患者并发肛周组织感染相关因素Meta分析

临床医学 | 更新时间：2026-01-09

- 恶性血液病患者并发肛周组织感染相关因素Meta分析
- Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis
- 第三军医大学学报 2020年42卷第17期页码：1763-1770
- 作者机构：
- 作者简介：
- 基金信息：
  
  陆军军医大学临床科研项目与人才培养计划(2018XLC3053);陆军军医大学临床科研项目与人才培养计划(2019XLC3014);重庆市自然科学基金面上项目(CSTC2019jcyjmsxmX0273);重庆市社会事业与民生保障科技创新专项(CSTC2016shms-ztzx10003)
- DOI：10.16016/j.1000-5404.202005137
  中图分类号：
- 收稿：2020-05-18，
  
  纸质出版：2020-09-15
- 稿件说明：
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陈小丽, 冯一梅, 孙恒蕊, 等. 恶性血液病患者并发肛周组织感染相关因素Meta分析[J]. 第三军医大学学报, 2020,42(17):1763-1770.

Xiaoli CHEN, Yimei FENG, Hengrui SUN, et al. Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis[J]. Journal of Third Military Medical University, 2020, 42(17): 1763-1770.
陈小丽, 冯一梅, 孙恒蕊, 等. 恶性血液病患者并发肛周组织感染相关因素Meta分析[J]. 第三军医大学学报, 2020,42(17):1763-1770. DOI： 10.16016/j.1000-5404.202005137.

Xiaoli CHEN, Yimei FENG, Hengrui SUN, et al. Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis[J]. Journal of Third Military Medical University, 2020, 42(17): 1763-1770. DOI： 10.16016/j.1000-5404.202005137.

摘要

Abstract

Objective

To analyze the risk factors of perianal infection in patients with malignant hematopathy in order to provide theoretical basis for the prevention.

Methods

Case-control studies and cohort studies concerning the related factors or the main risk factors for perianal tissue infection in patients with malignant hematopathy were retrieved from the indexed articles from PubMed

Cochrane Library

Web of Science

China National Knowledge Infrastructure Database (CNKI)

China Science and Technology Periodical Database (VIP)

and Wanfan Database. Two evaluators independently retrieved and screened the literature

extracted the data

and made methodological quality assessment of the included literatures a

nd cross-checked. Controversial issues were discussed and agreed by 3 evaluators together. Software Revman 5.3 was used for meta-analysis. A fixed-effect model or a random-effect model was used to combine odds ratio (

) values and 95% confidence intervals (

) to analyze each relevant risk factor

and sensitivity analysis was employed to assess the stability of the results.

Results

Eight literatures

containing a total of 1 857 cases were included for further analysis

including 272 cases (272/1 857

14.6%) in the perianal infection group and 1 585 cases in the control group. The results of meta-analysis showed that age older than 50 years

irremission after chemotherapy

and the absolute count of neutrophils

0.5×10

and acute myeloid leukemia were related to the formation of perianal infection in patients with hematopathy. There were no statistical difference in the incidence of perianal infection between male and female patients (

0.05).

Conclusion

The risk factors for perianal infection in patients with malignant hematologic disease are those aged over 50 years

unrelieved chemotherapy

and absolute value of neutrophils

0.5×10

/L and acute myeloid leukemia.

关键词

Keywords

references

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