新型冠状病毒肺炎患者转氨酶水平的Meta分析

刘维高; 金生

doi:10.16016/j.1000-5404.202004164

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新型冠状病毒肺炎患者转氨酶水平的Meta分析

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- 新型冠状病毒肺炎患者转氨酶水平的Meta分析
- Levels of alanine aminotransferase and aspartate aminotransferase in coronavirus disease 2019 patients: a meta-analysis
- 第三军医大学学报 2020年42卷第14期页码：1476-1483
- 作者机构：
  
  1.641100 四川内江, 内江市中医医院ICU
  2.400010 重庆，重庆医科大学附属第二医院感染与肝病中心
- 作者简介：
  
  [金生，E-mail: sheng_jin@163.comJIN Sheng, E-mail:sheng_jin@163.com
- 基金信息：
- DOI：10.16016/j.1000-5404.202004164
  中图分类号： R181.23;R446.112;R563.1
- 收稿：2020-04-16，
  
  修回：2020-05-28，
  
  纸质出版：2020-07-30
- 稿件说明：
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刘维高, 金生. 新型冠状病毒肺炎患者转氨酶水平的Meta分析[J]. 第三军医大学学报, 2020,42(14):1476-1483.

Weigao LIU, Sheng JIN. Levels of alanine aminotransferase and aspartate aminotransferase in coronavirus disease 2019 patients: a meta-analysis[J]. Journal of Third Military Medical University, 2020, 42(14): 1476-1483.
刘维高, 金生. 新型冠状病毒肺炎患者转氨酶水平的Meta分析[J]. 第三军医大学学报, 2020,42(14):1476-1483. DOI： 10.16016/j.1000-5404.202004164.

Weigao LIU, Sheng JIN. Levels of alanine aminotransferase and aspartate aminotransferase in coronavirus disease 2019 patients: a meta-analysis[J]. Journal of Third Military Medical University, 2020, 42(14): 1476-1483. DOI： 10.16016/j.1000-5404.202004164.

摘要

目的

评价新型冠状病毒肺炎(coronavirus disease 2019

COVID-19)患者转氨酶[丙氨酸转氨酶(alanine aminotransferase

ALT)和天冬氨酸转氨酶(aspartate aminotransferase

AST)]水平。

方法

检索PubMed、MedRxiv and bioRxiv、万方期刊数据库、中国期刊全文数据库(CNKI)、维普中文科技期刊数据库、中华医学期刊网等

搜集以COVID-19为主题的相关研究。检索时限均为建库至2020年4月10日。由两名评价员独立筛选文献、提取资料，采用RevMan 5.3软件进行Meta分析。

结果

共18项研究、2 405例患者纳入分析，其中非重型组1 898例，重型组507例。与非重型组比较，重型组发生转氨酶异常/肝损伤的比率显著高于非重型组患者，差异有统计学意义(

=0.35，95%

为0.27~0.46，

=7.78

0.000 01；

=0.53，95%

为0.46~0.61，

=8.60

0.000 01)；两组间转氨酶水平差异也具有统计学意义(ALT：MD=-0.63 U/L，95%

为-1.26~-0.01，

=2.00，

=0.05；AST：MD=-0.81 U/L

95%

为-1.45~-0.16，

=2.46，

=0.01)。

结论

COVID-19可合并肝损伤，重型患者转氨酶异常/肝损伤比率较非重型患者高，重型患者转氨酶水平异常更明显。

Abstract

Objective

To evaluate the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in coronavirus disease 2019 (COVID-19) patients.

Methods

PubMed

MedRxiv and bioRxiv

WangFang Data

CNKI

VIP

and Chinese Medical Journal Network databases were searched to collect researches for COVID-19 up to April 10

2020. RevMan 5.3 software was used for meta-analysis. Two evaluators independently screened the literature

extracted the data

and evaluated the risk of bias of relevant studies.

Results

There were 18 studies included. Among the 2 405 patients

1 898 of them suffered from not severe COVID-19 (non-severe group)

and the rest 507 patients from severe COVID-19 (severe group). The severe group had significantly higher proportion of trans

aminase abnormality/liver injury when compared with the non-severe group (

=0.35

95%

: 0.27~0.46

=7.78

0.000 01;

=0.53

95%

: 0.46~0.61

=8.60

0.000 01). Obvious differences were seen in the transferase levels between the 2 groups (ALT: MD=-0.63 U/L

95%

: -1.26~-0.01

Z=2.00

=0.05; AST: MD=-0.81 U/L

95%

: -1.45~-0.16

=2.46

=0.01).

Conclusion

COVID-19 maybe accompanied with liver injury. There are a larger proportion of patients with transaminase abnormality/liver injury in the severe COVID-19 patients

especially in the abnormality.

关键词

Keywords

references

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