浏览全部资源
扫码关注微信
男性高尿酸血症患者静息态脑功能磁共振成像研究
Functional brain abnormalities in male patients with hyperuricemia: a study by resting-state functional magnetic resonance imaging
- 第三军医大学学报 2020年42卷第14期 页码：1421-1427
- 作者机构：
400037 重庆，陆军军医大学(第三军医大学)第二附属医院放射科
- 作者简介：
[张冬, E-mail:zhangdongxqyy@163.comZHANG Dong, E-mail: zhangdongxqyy@163.com
- 基金信息：
DOI：10.16016/j.1000-5404.202003102
中图分类号： R445.2;R589.7;R741收稿：2020-03-08，
修回：2020-03-26，
纸质出版：2020-07-30
- 稿件说明：
移动端阅览
胡钧浩, 张偲, 范卫杰, 等. 男性高尿酸血症患者静息态脑功能磁共振成像研究[J]. 第三军医大学学报, 2020,42(14):1421-1427.
Junhao HU, Si ZHANG, Weijie FAN, et al. Functional brain abnormalities in male patients with hyperuricemia: a study by resting-state functional magnetic resonance imaging[J]. Journal of Third Military Medical University, 2020, 42(14): 1421-1427.
胡钧浩, 张偲, 范卫杰, 等. 男性高尿酸血症患者静息态脑功能磁共振成像研究[J]. 第三军医大学学报, 2020,42(14):1421-1427. DOI： 10.16016/j.1000-5404.202003102.
Junhao HU, Si ZHANG, Weijie FAN, et al. Functional brain abnormalities in male patients with hyperuricemia: a study by resting-state functional magnetic resonance imaging[J]. Journal of Third Military Medical University, 2020, 42(14): 1421-1427. DOI： 10.16016/j.1000-5404.202003102.
摘要
目的
2
探讨男性高尿酸血症患者静息状态下脑功能变化情况，探索血尿酸(serum uric acid，SUA)升高引起患者情绪及认知改变的神经生物学机制。
方法
2
选取2019年1-12月经社区招募的未经药物治疗的男性高尿酸血症患者(高尿酸血症组)及健康对照(对照组)各41例，行空腹血尿酸检测、神经心理测试和静息态功能磁共振(resting-state functional magnetic resonance imaging，rs-fMRI)扫描。利用低频振幅(amplitude of low-frequency fluctuation，ALFF)方法找出两组之间存在活动差异的脑区，随后行基于种子点与全脑各体素间的功能连接(functional connectivity，FC)分析。
结果
2
与对照组比较，高尿酸血症组左颞下回ALFF值减低，双侧额下回ALFF升高。以左颞下回极值点设种子点，与双侧楔叶间的FC强度增强；以左额下回极值点设种子点，与左侧丘脑、右尾状核间的FC强度增强。血尿酸、神经心理及认知测试结果显示：血尿酸浓度与工作记忆反应时间呈正相关(
r
=0.320，
P
=0.041)，工作记忆准确率与左侧颞下回中的ALFF值呈正相关(
r
=0.535，
P
<
0.001)，执行功能准确率与左侧及右额下回的ALFF值呈正相关(
r
=0.461，
P
=0.002；
r
=0.566，
P
<
0.001)，此外，左侧额下回与左侧丘脑及右侧尾状核之间FC强度分别与睡眠质量评分及贝克抑郁量表评分呈负相关(
r
=-0.361，
P
=0.020；
r
=-0.343，
P
=0.028)。
结论
2
男性高尿酸血症患者在区域及网络水平上存在脑功能异常。
Abstract
Objective
2
To assess the brain functions and explore the neurobiological mechanism of emotional and cognitive changes in male patients with hyperuricemia.
Methods
2
Forty-one untreated male patients with hyperuricemia and 41 healthy control subjects were recraited through communities during
and all of them underwent examinations of fasting serum uric acid (SUA)
neuropsychological test and resting-state functional magnetic resonance imaging (rs-fMRI). The amplitude of low-frequency fluctuation (ALFF) was analyzed to determine the seed points
and the functional connections between the abnormal seed points and the voxels of the whole brain were analyzed.
Results
2
The patients with hyperuricemia showed significantly decreased ALFF in the left inferior temporal gyrus (ITG.L) and increased ALFF in the bilateral inferior frontal gyrus (IFG.B) compared with the control subjects. The FC intensity of the bilateral cuneus (CUN.B) was enhanced when the extreme point of ITG.L was chosen as the seed point; the intensity of functional connection between the left thalamus (THA.L) and the right caudate nucleus (CAU.R) was enhanced when the extreme point of the IFG.L was the seed point. The results of SUA analysis and neuropsychological and behavioral tests showed that SUA levels were inversely correlated with the working memory reaction time (
r
=0.320
P
=0.041)
and the ALFF in the ITG.L was positively correlated with the working memory accuracy (
r
=0.535
P
<
0.001). The ALFF in IFG.L and IFG.R was positively correlated with the accuracy of the executive function (
r
=0.461
P
=0.002;
r
=0.566
P
<
0.001
respectively); the strength of functional connection of the IFG.L with the THA.L and with the CAU.R was inversely correlated with sleep quality (
r
=-0.361
P
=0.020) and depressive state (
r
=-0.343
P
=0.028) of the patients
respectively.
Conclusion
2
Brain abnormalities at regional and network levels are present in male patients with hyperuricemia
and these findings provide new insights into the mechanisms underlying the cognitive and emotional changes in patients with hyperuricemia.
关键词
Keywords
references
CICERO A F, DESIDERI G, GROSSI G, et al . Serum uric acid and impaired cognitive function in a cohort of healthy young elderly: data from the Brisighella Study[J ] . Intern Emerg Med, 2015, 10(1): 25-31. DOI: 10.1007/s11739-014-1098-z.
KHAN A A, QUINN T J, HEWITT J, et al . Serum uric acid level and association with cognitive impairment and dementia: systematic review and meta-analysis[J ] . Age (Dordr), 2016, 38(1): 16. DOI: 10.1007/s11357-016-9871-8.
SHAO X, LU W, GAO F, et al . Uric acid induces cognitive dysfunction through hippocampal inflammation in rodents and humans[J ] . J Neurosci, 2016, 36(43): 10990-11005. DOI: 10.1523/jneurosci.1480-16.2016.
MAZUMDER M K, PHUKAN B C, BHATTACHARJEE A, et al . Disturbed purine nucleotide metabolism in chronic kidney disease is a risk factor for cognitive impairment[J ] . Med Hypotheses, 2018, 111: 36-39. DOI: 10.1016/j.mehy.2017.12.016.
KANBAY M, YILMAZ M I, SONMEZ A, et al . Serum uric acid level and endothelial dysfunction in patients with nondiabetic chronic kidney disease[J ] . Am J Nephrol, 2011, 33(4): 298-304. DOI: 10.1159/000324847.
KANG D H, PARK S K, LEE I K, et al . Uric acid-induced C-reactive protein expression: implication oncell proliferation and nitric oxide production of human vascular cells[J ] . J Am Soc Nephrol, 2005, 16(12): 3553-3562. DOI: 10.1681/asn.2005050572.
LATOURTE A, BARDIN T, RICHETTE P. Uric acid and cognitive decline: a double-edge sword?[J]. Curr Opin Rheumatol, 2018, 30(2): 183-187. DOI: 10.1097/BOR.0000000000000472.
PALMERY M, REGGI R, PELUSO I. Uric acid and cognition: what is the connection?[J]. Biomed Rev, 2017, 27: 51-57. DOI: 10.14748/bmr.v27.2111.
WOLOSZYN L, SHEINBERG D L. Neural dynamics in inferior temporal cortex during a visual working memory task[J]. J Neurosci, 2009, 29(17): 5494-5507. DOI: 10.1523/JNEUROSCI.5785-08.2009.
DREHER J C, KOCH P, KOHN P, et al . Common and differential pathophysiological features accompany comparable cognitive impairments in medication-free patients with schizophrenia and in healthy aging subjects[J ] . Biol Psychiatry, 2012, 71(10): 890-897. DOI: 10.1016/j.biopsych.2012.01.002.
SCHROETER M L, VOGT B, FRISCH S, et al . Executive deficits are related to the inferior frontal junction in early dementia[J ] . Brain, 2012, 135(Pt 1): 201-215. DOI: 10.1093/brain/awr311.
LYNGDOH T, MARQUES-VIDAL P, PACCAUD F, et al . Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study[J ] . PLoS ONE, 2011, 6(5): e19901. DOI: 10.1371/journal.pone.0019901.
JAN J E, REITER R J, WASDELL M B, et al . The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders[J ] . J Pineal Res, 2009, 46(1): 1-7. DOI: 10.1111/j.1600-079X.2008.00628.x.
BUTTERS M A, AIZENSTEIN H J, HAYASHI K M, et al . Three-dimensional surface mapping of the caudate nucleus in late-life depression[J ] . Am J Geriatr Psychiatry, 2009, 17(1): 4-12. DOI: 10.1097/JGP.0b013e31816ff72b.
KUEIDER A M, AN Y, TANAKA T, et al . Sex-dependent associations of serum uric acid with brain function during aging[J ] . J Alzheimers Dis, 2017, 60(2): 699-706. DOI: 10.3233/JAD-170287.
0
浏览量
0
下载量
0
CSCD
- 网络PDF下载
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
- 技术支持由北京北大方正电子有限公司提供 京ICP备09064830号-19
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies
