四联益生菌联合低聚半乳糖预防颅脑内伤重症患者腹泻研究

李利; 杨昊; 何涛; 朱文艺; 刘俊; 付华; 王建

doi:10.16016/j.1000-5404.202003003

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四联益生菌联合低聚半乳糖预防颅脑内伤重症患者腹泻研究

临床医学 | 更新时间：2026-01-09

- 四联益生菌联合低聚半乳糖预防颅脑内伤重症患者腹泻研究
- Tetralogy probiotics combined with galactooligosaccharides in prevention of diarrhea in patients with severe craniocerebral injury
- 第三军医大学学报 2020年42卷第15期页码：1562-1566
- 作者机构：
  
  1.400037 重庆，陆军军医大学(第三军医大学)第二附属医院:营养科
  2.00037 重庆，陆军军医大学(第三军医大学)第二附属医院:神经内科
- 作者简介：
  
  [ 王建，E-mail: wangjian_1996@aliyun.com WANG Jian, E-mail:wangjian_1996@aliyun.com
- 基金信息：
- DOI：10.16016/j.1000-5404.202003003
  中图分类号： R442.2;R651.15;R977.6
- 收稿：2020-03-01，
  
  修回：2020-05-11，
  
  纸质出版：2020-08-15
- 稿件说明：
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李利, 杨昊, 何涛, 等. 四联益生菌联合低聚半乳糖预防颅脑内伤重症患者腹泻研究[J]. 第三军医大学学报, 2020,42(15):1562-1566.

Li LI, Hao YANG, Tao HE, et al. Tetralogy probiotics combined with galactooligosaccharides in prevention of diarrhea in patients with severe craniocerebral injury[J]. Journal of Third Military Medical University, 2020, 42(15): 1562-1566.
李利, 杨昊, 何涛, 等. 四联益生菌联合低聚半乳糖预防颅脑内伤重症患者腹泻研究[J]. 第三军医大学学报, 2020,42(15):1562-1566. DOI： 10.16016/j.1000-5404.202003003.

Li LI, Hao YANG, Tao HE, et al. Tetralogy probiotics combined with galactooligosaccharides in prevention of diarrhea in patients with severe craniocerebral injury[J]. Journal of Third Military Medical University, 2020, 42(15): 1562-1566. DOI： 10.16016/j.1000-5404.202003003.

摘要

目的

观察四联益生菌和低聚半乳糖对颅脑内伤ICU重症患者腹泻的影响。

方法

采用病例对照研究，纳入因颅脑内伤入住第二附属医院神经内科重症加护病房(ICU)危重症患者共90例，按随机数字表法分为试验组和对照组(

=45)。对照组采用常规营养治疗，试验组采用常规营养治疗联合四联益生菌和低聚半乳糖，两组均通过鼻胃管连续滴注肠内营养液治疗5 d，记录患者腹泻情况、ICU停留时间、胃管留置时间、血清总蛋白(total serum protein，TP)、血清白蛋白(serum albumin，ALB)、血清前白蛋白(prealbumin，PA)等并进行比较。

结果

试验组腹泻发生率显著低于对照组(2.22%

17.78%

0.05)。试验组的胃管留置时间显著短于对照组[(10.04±5.39)d

(14.27±8.14)d

0.01

]

。营养治疗前对照组和试验组TP、ALB、PA相比差异无统计学意义(

0.05)。营养治疗第5天试验组的PA明显高于对照组[(180.50±58.73)mg/L

(169.55±67.85)mg/L

0.01

]

。

结论

在使用肠内营养滴注的同时加用四联益生菌和低聚半乳糖可以有效预防神内重症患者出现腹泻症状，改善营养状况，缩短胃管留置时间。

Abstract

Objective

To observe the clinical effect of tetralogy probiotics combined with galactooligosaccharides on diarrhea in patients after severe craniocerebral injury.

Methods

A case-control study was conducted on 90 patients with severe craniocerebral injury admitted in the intensive care unit (ICU) of neurological department of our hospital during January to June 2019. They were randomly divided into control and experimental groups

with 45 patients in each group. The patients of the former group was given conventional nutrition therapy

while those of the latter group were treated with conventional nutrition therapy combined with tetralogy probiotics and galactooligosaccharides. After 5 days' enteral nutrition through nasogastric tube

occurrence of diarrhea

ICU duration

indwelling time of gastric tube

and serum levels of total serum protein (TP)

albumin (ALB) and prealbumin (PA) were recorded and compared between the 2 groups.

Results

The experimental group h

ad significantly lower incidence of diarrhea (2.22%

17.78%

0.05)

and shorter indwelling time of gastric tube (10.04±5.39

14.27±8.14 d

0.01) when compared with the control group. There were no statistical differences in the TP

ALB and PA levels between the 2 groups before nutrition treatment (

0.05). On the 5th day post nutritional treatment

the PA level of the experimental group was obviously higher than that of the control group (180.50±58.73

169.55±67.85 mg/L

0.01).

Conclusion

Conventional nutrition therapy combined with tetralogy probiotics and galactooligosaccharides can effectively prevent diarrhea in patients after severe craniocerebral injury

improve their nutritional status and shorten the indwelling time of gastric tube.

关键词

Keywords

references

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