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空腹血糖受损伴高血压患者5年随访观察胰岛素抵抗的变化
Change of insulin resistance in impaired fasting glucose patients with hypertension: a follow-up study of 5 years
- 第三军医大学学报 2020年42卷第11期 页码：1136-1140
- 作者机构：
- 作者简介：
- 基金信息：
DOI：10.16016/j.1000-5404.202003002
中图分类号：收稿：2020-03-01，
纸质出版：2020-06-15
- 稿件说明：
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郎博, 段姗姗, 冷蔚玲, 等. 空腹血糖受损伴高血压患者5年随访观察胰岛素抵抗的变化[J]. 第三军医大学学报, 2020,42(11):1136-1140.
Bo LANG, Shanshan DUAN, Weiling LENG, et al. Change of insulin resistance in impaired fasting glucose patients with hypertension: a follow-up study of 5 years[J]. Journal of Third Military Medical University, 2020, 42(11): 1136-1140.
郎博, 段姗姗, 冷蔚玲, 等. 空腹血糖受损伴高血压患者5年随访观察胰岛素抵抗的变化[J]. 第三军医大学学报, 2020,42(11):1136-1140. DOI： 10.16016/j.1000-5404.202003002.
Bo LANG, Shanshan DUAN, Weiling LENG, et al. Change of insulin resistance in impaired fasting glucose patients with hypertension: a follow-up study of 5 years[J]. Journal of Third Military Medical University, 2020, 42(11): 1136-1140. DOI： 10.16016/j.1000-5404.202003002.
摘要
Abstract
Objective
2
To observe the change of insulin resistance in the impaired fasting glucose patients with hypertension along with time elapse
and to investigate the relationship between hypertension and insulin resistance.
Methods
2
A total of 180 patients with impaired fasting glucose admitted in our outpatient department of endocrinology and physical examination center of our hospital during October 2012 and August 2013 were recruited in this study. All of them were given long-term lifestyle intervention
and were followed up for 5 years. Till the end of the follow-up
there were 114 patients included
and they were divided into the hypertension group (
n
=56) and the normal blood pressure group (
n
=58). Routine antihypertensive drugs were given to the hypertension group. Clinical data
such as fasting blood glucose
2 h postprandial blood glucose
fasting insulin
2 h postprandial insulin
and insulin resistance index (HOMA-IR) and insulin sensitivity index (ISI) from the third to the fifth year of follow-up w
ere collected and analyzed.
Results
2
In the 5 years' follow-up
the prevalence of diabetes in the hypertension group was 22.83%
significantly higher than that of the normal blood pressure group (11.36%
P
=0.042). The hypertension group had obviously higher HOMA-IR but statistically lower ISI when compared with the normal blood pressure group (both
P
<
0.001).
Conclusion
2
In the patients with impaired fasting glucose
elevated blood pressure is closely associated with insulin resistance. As time goes by
those impaired fasting glucose accompanied with hypertension are more prone to severe insulin resistance
and are more likely to progress to diabetes.
关键词
Keywords
references
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