新型冠状病毒肺炎治疗药物的研究现状及对策建议

邹全明; 李海波; 曾浩

doi:10.16016/j.1000-5404.202002233

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新型冠状病毒肺炎治疗药物的研究现状及对策建议

特别报道：新型冠状病毒病的防控(2) | 更新时间：2026-01-09

- 新型冠状病毒肺炎治疗药物的研究现状及对策建议
- Current status and countermeasures for development of drugs to treat coronavirus disease 2019
- 第三军医大学学报 2020年42卷第9期页码：861-866
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)药学与检验医学系微生物与生化药学教研室，国家免疫生物制品工程技术研究中心
- 作者简介：
  
  [ "邹全明, 博士, 教授, 博士生导师。担任国务院学位委员会学科评议组药学组成员、第十届国家药典委员会委员。主持“十二五”国家科技支撑计划、国家高技术研究发展计划(863计划)、国家科技重大专项等国家及军队重大、重点课题12项。成功主持研制世界首个预防胃病的幽门螺杆菌疫苗并获1类新药证书, 获国家技术发明二等奖。主持研究的国际首个五组分金黄色葡萄球菌疫苗已开展Ⅱ期临床试验。以第一发明人获国家发明专利授权25项, 国际PCT专利4项。目前正在主持研制的原创疫苗5个。以通信作者发表并被SCI收录的论文80余篇, 其中在《柳叶刀》(Lancet)发表论著1篇。主要从事临床微生物、临床免疫、分子免疫学、生物制药方面的研究。E-mail:qmzou2007@163.com" ]
  [ "李海波, 博士, 副教授, 硕士生导师, 主要从事微生物与生化药学方面的研究。E-mail:lihaibo@tmmu.edu.cn" ]
  [ "曾浩, 博士, 教授, 博士生导师, 主要从事微生物与生化药学方面的研究。E-mail: zeng1109@163.com" ]
- 基金信息：
  
  国家自然科学基金面上项目(31670936);重庆市新型冠状病毒感染肺炎疫情应急科技攻关专项(2020)
- DOI：10.16016/j.1000-5404.202002233
  中图分类号： R563.106;R978.7
- 收稿：2020-02-29，
  
  修回：2020-03-04，
  
  纸质出版：2020-05-15
- 稿件说明：
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邹全明, 李海波, 曾浩. 新型冠状病毒肺炎治疗药物的研究现状及对策建议[J]. 第三军医大学学报, 2020,42(9):861-866.

Quanming ZOU, Haibo LI, Hao ZENG. Current status and countermeasures for development of drugs to treat coronavirus disease 2019[J]. Journal of Third Military Medical University, 2020, 42(9): 861-866.
邹全明, 李海波, 曾浩. 新型冠状病毒肺炎治疗药物的研究现状及对策建议[J]. 第三军医大学学报, 2020,42(9):861-866. DOI： 10.16016/j.1000-5404.202002233.

Quanming ZOU, Haibo LI, Hao ZENG. Current status and countermeasures for development of drugs to treat coronavirus disease 2019[J]. Journal of Third Military Medical University, 2020, 42(9): 861-866. DOI： 10.16016/j.1000-5404.202002233.

摘要

自新型冠状病毒(SARS-CoV-2)疫情发生以来，国内外多家研究机构投入到抗新型冠状病毒肺炎(简称新冠肺炎，coronavirus disease 2019

COVID-19)的药物研发中。目前主要采取老药新用的策略，筛选抗新冠病毒和抑制过度免疫反应的候选药物，相关研究已经取得了重要进展。本文在综述已经纳入国家卫健委印发的新型冠状病毒肺炎诊疗方案中以及在体外已经证实对新型冠状病毒具有抑制作用的药物研发和临床应用的现状的基础上，对未来新冠肺炎治疗药物的研究对策提出建议:①从“老药新用”策略向创新药物研发转变；②构建可靠的体内外药物筛选模型；③建立新冠肺炎药物研发的协同创新机制；④有序开展新冠肺炎的药物临床试验；⑤建立冠状病毒研发的长效机制。

Abstract

Since the outbreak of the epidemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

or 2019 novel coronavirus (2019-nCoV) provisionally

many research institutions at home and abroad have involved in t

he research and development (R

D) of drugs against coronavirus disease 2019 (COVID-19). At present

the strategy of new use of old drugs is used to screen candidate drugs which inhibit the virus or excessive immune response

and the related researches have made important progress. This article reviewed current status of development and clinical application of those drugs which have been included in the diagnosis of novel coronavirus-infected pneumonia and treatment protocols which have been shown to inhibit the virus

in vitro

. In addition

we have following suggestions for future researches on the development of novel drugs against COVID-19: ① from "new use of old drugs" strategy to innovative drug R

D; ② building reliable models for screening drugs

in vitro

and

in vivo

; ③establishing a synergistic innovation mechanism for drug R

D against COVID-19; ④conducting clinical trials of the drugs in order; ⑤ establishing a long-term mechanism for drug R

D against COVID-19.

关键词

Keywords

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