重庆市某医院89例新型冠状病毒肺炎患者的临床特征分析

黄澄澄; 庞科; 高红丽

doi:10.16016/j.1000-5404.202002143

您当前的位置：

首页 >

文章列表页 >

重庆市某医院89例新型冠状病毒肺炎患者的临床特征分析

特别报道：新型冠状病毒病的防控(2) | 更新时间：2026-01-09

- 重庆市某医院89例新型冠状病毒肺炎患者的临床特征分析
- Clinical characteristics of coronavirus disease 2019 in a Chongqing hospital: analysis of 89 cases
- 第三军医大学学报 2020年42卷第9期页码：883-886
- 作者机构：
  
  1.402160 重庆，重庆医科大学附属永川医院老年病科
  2.02160 重庆，重庆医科大学附属永川医院老年病科及新冠病房
  3.02160 重庆，重庆医科大学附属永川医院超声科
- 作者简介：
  
  [ 庞科, E-mail:21081882@qq.com PANG Ke, E-mail:21081882@qq.com
- 基金信息：
  
  重庆市永川区科技局新型冠状病毒肺炎应急项目(YCSTC2020nb0209)
- DOI：10.16016/j.1000-5404.202002143
  中图分类号： R181.32;R373.1;R563.19
- 收稿：2020-02-20，
  
  修回：2020-03-07，
  
  纸质出版：2020-05-15
- 稿件说明：
移动端阅览
黄澄澄, 庞科, 高红丽. 重庆市某医院89例新型冠状病毒肺炎患者的临床特征分析[J]. 第三军医大学学报, 2020,42(9):883-886.

Chengcheng HUANG, Ke PANG, Hongli GAO. Clinical characteristics of coronavirus disease 2019 in a Chongqing hospital: analysis of 89 cases[J]. Journal of Third Military Medical University, 2020, 42(9): 883-886.
黄澄澄, 庞科, 高红丽. 重庆市某医院89例新型冠状病毒肺炎患者的临床特征分析[J]. 第三军医大学学报, 2020,42(9):883-886. DOI： 10.16016/j.1000-5404.202002143.

Chengcheng HUANG, Ke PANG, Hongli GAO. Clinical characteristics of coronavirus disease 2019 in a Chongqing hospital: analysis of 89 cases[J]. Journal of Third Military Medical University, 2020, 42(9): 883-886. DOI： 10.16016/j.1000-5404.202002143.

摘要

目的

分析重庆医科大学附属永川医院收治的89例新型冠状病毒肺炎患者的临床特征。

方法

回顾性分析2020年1月22日至2020年2月17日重庆医科大学附属永川医院收治的89例新型冠状病毒肺炎患者的流行病学资料、临床症状及实验室检查结果。

结果

发热和咳嗽为COVID-19的主要症状，但仍有6例无症状携带者；重型组的淋巴细胞绝对值、淋巴细胞百分比、CD3

细胞计数、CD4

细胞计数、CD8

细胞计数明显低于普通组，差异具有统计学意义(

0.05)。重型组的C反应蛋白及IL-6水平明显高于普通组及轻症组，差异具有统计学意义(

0.05)。病情严重程度与年龄、患2型糖尿病、C反应蛋白水平、IL-6水平呈正相关，而与淋巴细胞、CD3

细胞、CD4

细胞及CD8

细胞计数呈负相关。多因素Logistic回归分析提示，C反应蛋白升高及CD8

细胞计数降低是重症COVID-19的独立影响因素。

结论

新型冠状病毒肺炎发热咳嗽为主要症状，C反应蛋白及CD8细胞计数对病情评估有帮助，免疫功能与病情严重程度密切相关。

Abstract

Objective

To analyze the clinical characteristics of 89 cases of coronavirus disease 2019 (COVID-19) in Yongchuan Hospital of Chongqing Medical University.

Methods

The epidemiological data

clinical symptoms and results of laboratory tests of 89 COVID-19 patients admitted in our hospital from January 22 to February 17 2020 were collected and retrospectively analyzed.

Results

Fever and cough were the main

symptoms of COVID-19

but there were 6 asymptomatic carriers in the cohort. The severe group had significantly lower lymphocyte absolute value

lymphocyte percentage

and the counts of CD3

CD4

and CD8

cells when compared with the ordinary group (

0.05). The severe group also had obviously high levels of C-reactive protein and IL-6 than the ordinary and mild groups (

0.05). The severity of the disease was positively correlated with age

type 2 diabetes

C-reactive protein and IL-6 levels

and negatively correlated with the counts of lymphocytes

CD3

CD4

and CD8

cells. Multivariate Logistic regression analysis indicated that increased C-reactive protein and decreased CD8

cell count were independent factors for the severity of the condition.

Conclusion

Fever and cough are the main symptoms of COVID-19. C-reactive protein and CD8

cell count are helpful for the assessment of the disease

and immune function is closely related to the severity of the disease.

关键词

Keywords

references

中国疾病预防控制中心新型冠状病毒肺炎应急响应机制流行病学组.新型冠状病毒肺炎流行病学特征分析[J].中华流行病学杂志, 2020, 41(2): 145-151. DOI: 10.3760/cma.j.issn.0254-6450.2020.02.003.

Novel Coronavirus Pneumonia Emergency Response Epidemiology Team of Chinese Center for Disease Control and Prevention. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China[J]. Chin J Epidemiol, 2020, 41(2): 145-151. DOI: 10.3760/cma.j.issn.0254-6450.2020.02.003.

国家卫生健康委.新型冠状病毒感染的肺炎诊疗方案(试行第五版)[J].中国中西医结合杂志, 2020: 1-3. DOI:10.7661/j.cjim.20200202.064.

National Health Commission. Diagnosis and treatment of pneumonia caused by new coronavirus infection (trial version 5)[J]. Chin J Integr Trad West Med, 2020: 1-3. DOI:10.7661/j.cjim.20200202.064.

WU F, ZHAO S, YU B, et al . A new coronavirus associated with human respiratory disease in China[J ] . Nature, 2020, 579(7798): 1-8. DOI:10.1038/s41586-020-2008-3.

[中华医学会儿科学分会, 中华儿科杂志编辑委员会.儿童2019新型冠状病毒感染的诊断与防治建议(试行第一版)[J ] .中华儿科杂志, 2020, 58(3): 169-174.DOI: 10.3760/cma.j.issn.0578-1310.2020.03.001 http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2020.03.001 .

[Branch of Pediatrics of Chinese Medical Association. Recommendations for the diagnosis, prevention and control of the 2019 novel coronavirus infection in children (first in terim edition)[J ] . Chin J Pediatr, 2020, 58(3): 169-174.DOI: 10.3760/cma.j.issn.0578-1310.2020.03.001 http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2020.03.001 .

杜永浩, 金晨望, 杨健, 等.家庭聚集性早期新型冠状病毒肺炎的临床与CT表现初步探讨[J].西安交通大学学报(医学版), 2020, 41(2): 215.

DU Y H, JIN C W, YANG J, et al . Preliminary study of clinical and CT manifestations of family-associated early new-type coronavirus pneumonia[J ] . J Xi'an Jiaotong Univ (Med Edition), 2020, 41(2): 215.

PREGLEJ T, HAMMINGER P, LUU M, et al . Histone deacetylases 1 and 2 restrain CD4 + cytotoxic T lymphocytedifferentiation[J ] . JCI Insight, 2020, 5(4): 133393. DOI:10.1172/jci.insight.133393..

STENGER S, HANSON D A, TEITELBAUM R, et al . An antimicrobial activity of cytolytic T cells mediated by granulysin[J ] . Science, 1998, 282(5386): 121-125. DOI:10.1126/science.282.5386.121.

陈威巍, 谢杨新, 张云辉, 等.甲型H1N1流感患者外周血白细胞和淋巴细胞亚群变化分析[J].中华实验和临床病毒学杂志, 2010, 24(5): 331-333. DOI:10.3760/cma.j.issn.1003-9279.2010.05.004.

CHEN W W, XIE Y X, ZHANG Y H, et al . Changes and analysis of peripheral white blood cells and lymphocyte subsets for patients with p andemic influenza A virus (H1N1) infection[J ] . Chin J Exp Clin Virol, 2010, 24(5): 331-333. DOI:10.3760/cma.j.issn.1003-9279.2010.05.004.

ZHAO Y, ZHANG Y H, DENNEY L, et al . High levels of virus-specific CD4 + T cells predict severe pandemic influenza A virus infection[J ] . Am J Respir Crit Care Med, 2012, 186(12): 1292-1297. DOI:10.1164/rccm.201207-1245OC..

HIGDON M M, LE T, O'BRIEN K L, et al . Association of C-reactive protein with bacterial and respiratory syncytial virus-associated pneumonia among children aged 5 years in the PERCH study[J ] . Clin Infect Dis, 2017, 64(suppl_3): S378-S386. DOI:10.1093/cid/cix150.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

基于CT影像组学特征联合临床特征预测非小细胞肺癌EGFR突变状态

119例肝豆状核变性临床特征及致病基因ATP7B变异谱分析

粪便钙卫蛋白联合血清C反应蛋白在成人重症艰难梭菌感染中的诊断价值

侵袭性肺真菌感染病临床影像预测模型的初步建立及评价

HBeAg/HBeAb双阳性慢性乙型肝炎患者不同抗病毒方案疗效及临床转归分析