重庆市渝东北片区143例2019冠状病毒病患者临床特征分析

陈亚娟; 税莉莉; 庞小华; 牟华明; 汪建兵; 郎春辉; 吕敬龙; 孙锎; 李稳发; 肖开虎

doi:10.16016/j.1000-5404.202002097

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重庆市渝东北片区143例2019冠状病毒病患者临床特征分析

特别报道：新型冠状病毒病的防控 | 更新时间：2026-01-09

- 重庆市渝东北片区143例2019冠状病毒病患者临床特征分析
- Clinical features of coronavirus disease 2019 in Northeast area of Chongqing: analysis of 143 cases
- 第三军医大学学报 2020年42卷第6期页码：549-554
- 作者机构：
- 作者简介：
- 基金信息：
  
  2018年留创计划创新类启动项目(cx2018141)
- DOI：10.16016/j.1000-5404.202002097
  中图分类号：
- 收稿：2020-02-15，
  
  纸质出版：2020-03-30
- 稿件说明：
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陈亚娟, 税莉莉, 庞小华, 等. 重庆市渝东北片区143例2019冠状病毒病患者临床特征分析[J]. 第三军医大学学报, 2020,42(6):549-554.

Yajuan CHEN, Lili SHUI, Xiaohua PANG, et al. Clinical features of coronavirus disease 2019 in Northeast area of Chongqing: analysis of 143 cases[J]. Journal of Third Military Medical University, 2020, 42(6): 549-554.
陈亚娟, 税莉莉, 庞小华, 等. 重庆市渝东北片区143例2019冠状病毒病患者临床特征分析[J]. 第三军医大学学报, 2020,42(6):549-554. DOI： 10.16016/j.1000-5404.202002097.

Yajuan CHEN, Lili SHUI, Xiaohua PANG, et al. Clinical features of coronavirus disease 2019 in Northeast area of Chongqing: analysis of 143 cases[J]. Journal of Third Military Medical University, 2020, 42(6): 549-554. DOI： 10.16016/j.1000-5404.202002097.

摘要

Abstract

Objective

To explore the clinical features of 143 patients suffering from coronavirus disease 2019 (COVID-19) in the Northeast area of Chongqing.

Methods

A total of 143 COVID-19 patients who were positive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by nucleic acid test in nasopharyngeal swab and had typical CT characteristics of the novel coronavirus-infected pneumonia from Jan. 23 to Feb. 8 in 2020 were recruited in this study. Their epidemiology and clinical features were collected and retrospectively analyzed. And the differences in laboratory results were compared among the groups of different clinical classification. The treatment and clinical outcomes were also analyzed.

Results

Among the 143 patients with confirmed COVID-19

76 of them (76/143

53.1%) came from the epidemic area

Wuhan

52 (36.4%) had the contact history with the infected cases

and 15(10.5%) had no contact history of with those from epidemic areas. According to their conditions

they were assigned into ordinary group (

=107

74.8%)

severe group (

=24

16.8%) and critical group (

=12

8.4%). Their main clinical symptoms were fever

cough

headache and fatigue. And

11 patients had no clinical symptoms. The most common comorbidities were hypertension and diabetes

followed by chronic gastritis

hepatitis B and tuberculosis. Laboratory results indicated that the patients with decreased WBC accounted for 25.8%

and those with decreased for 44.8% in all the patients. The more severe the condition was

the lower lymphocyte count was decreased

and significant differences were seen in the count among the 3 groups (

0.05). The serum levels of C-reactive protein (CRP)

procalcitonin (PCT) and IL-6 rose when compared with the normal levels

and the increments were associated with the severity of the disease

with statistical difference among the 3 groups (

0.05).

Conclusion

No specific manifestations are identified in COIVD-19

and some patients may have no symptoms. But chest abnormal views of multiple macular patches and interstitial changes could be observed in early stage of this disease. For those who have contact history with the infected or suspected

nucleic acid test and chest radiology should be performed as early as possible. The absolute decrease of peripheral blood lymphocyte count is an index for the severity and prognosis of the disease. The dynamic follow-up of CRP

IL-6 and PCT can be used to make prediction for severe disease in the early stage and be helpful in guidance of treatment. Complicated metabolic and cardiovascular diseases are the risk factors for poor prognosis.

关键词

Keywords

references

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