肝硬化腹水患者的腹水endocan水平在自发性腹膜炎诊断中的作用

伍先梅; 罗俊力; 黄文祥; 贾蓓

doi:10.16016/j.1000-5404.202002092

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肝硬化腹水患者的腹水endocan水平在自发性腹膜炎诊断中的作用

临床医学 | 更新时间：2026-01-09

- 肝硬化腹水患者的腹水endocan水平在自发性腹膜炎诊断中的作用
- Role of ascitic endocan level in diagnosis of spontaneous bacterial peritonitis in patients with cirrhotic ascites
- 第三军医大学学报 2020年42卷第13期页码：1338-1344
- 作者机构：
  
  400016 重庆, 重庆医科大学附属第一医院感染科, 重庆市传染病寄生虫病学重点实验室
- 作者简介：
  
  [ 贾蓓, E-mail: jiabei@hospital.cqmu.edu.cn JIA Bei, E-mail:jiabei@hospital.cqmu.edu.cn
- 基金信息：
  
  重庆市卫生健康委员会中青年医学高端人才资助项目(2018GDRC002)
- DOI：10.16016/j.1000-5404.202002092
  中图分类号： R446.19;R575.2;R656.41
- 收稿：2020-02-15，
  
  修回：2020-04-17，
  
  纸质出版：2020-07-15
- 稿件说明：
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伍先梅, 罗俊力, 黄文祥, 等. 肝硬化腹水患者的腹水endocan水平在自发性腹膜炎诊断中的作用[J]. 第三军医大学学报, 2020,42(13):1338-1344.

Xianmei WU, Junli LUO, Wenxiang HUANG, et al. Role of ascitic endocan level in diagnosis of spontaneous bacterial peritonitis in patients with cirrhotic ascites[J]. Journal of Third Military Medical University, 2020, 42(13): 1338-1344.
伍先梅, 罗俊力, 黄文祥, 等. 肝硬化腹水患者的腹水endocan水平在自发性腹膜炎诊断中的作用[J]. 第三军医大学学报, 2020,42(13):1338-1344. DOI： 10.16016/j.1000-5404.202002092.

Xianmei WU, Junli LUO, Wenxiang HUANG, et al. Role of ascitic endocan level in diagnosis of spontaneous bacterial peritonitis in patients with cirrhotic ascites[J]. Journal of Third Military Medical University, 2020, 42(13): 1338-1344. DOI： 10.16016/j.1000-5404.202002092.

摘要

目的

探索肝硬化腹水患者的腹水endocan水平在自发性腹膜炎(spontaneous bacterial peritonitis

SBP)诊断中的作用。

方法

纳入2018年1月至2019年6月在我院住院的失代偿性肝硬化腹水患者161例

其中SBP组35例

非SBP组126例

留取入院时腹水标本

同时收集人口学资料及实验室检查资料

用ELISA方法检测腹水中endocan浓度

采用logstic回归模型分析SBP的独立影响因素

ROC曲线分析腹水endocan对SBP的诊断价值。

结果

腹水endocan水平在SBP组显著高于非SBP组(318.762~460.673)pg/mL

199.838(133.366~303.226)pg/mL

0.001

]

。logistic回归模型进行SBP影响因素分析结果显示腹水endocan为SBP的独立危险因素1.012)

0.001

]

。ROC曲线分析显示腹水endocan诊断SBP的曲线下面积(AUC)为0.822(

0.001)

临界值为280.983pg/ml时敏感性为88.57%

特异性为70.63%

在年龄大于等于60岁和小于60岁患者中

腹水endocan诊断SBP的AUC分别为0.852和0.789。

结论

腹水endocan水平是肝硬化腹水患者SBP的独立危险因素

是SBP有价值的诊断指标

且在年龄大于等于60岁患者的诊断价值更大。

Abstract

Objective

To explore the role of ascitic endocan level in the diagnosis of spontaneous bacterial peritonitis (SBP) in the patients with cirrhotic ascites.

Methods

A total of 161 ascitic patients with decompensated cirrhosis admitted to our hospital from January 2018 to June 2019 were recruited in this study

and 35 of them suffered from SBP and served as SBP group

and the other 126 as non-SBP group. Ascitic samples were obtained at admission. Demographic data and laboratory parameters were collected. The ascitic endocan level was measured by ELISA. Logistic regression analysis was used to analyze the independent influencing factors for SBP

and receiver operating characteristic (ROC) curve were used to analyze the diagnostic value of ascitic endocan level for SBP.

Results

The level of ascitic endocan was significantly higher in the SBP group than the non-SBP group. Logistic regression analysis showed that the ascitic endocan level was an independent risk factor for SBP (

=1.008

95%

: 1.004~1.012

0.001). The result of ROC curve indicated that the area under the curve (AUC) of ascitic endocan was 0.822 (

0.001)

and the sensitivity was 88.57% and the specificity was 70.63% when the cut-off value was 280.983 pg/mL. The AUCs of ascitic endocan for the diagnosis of SBP were 0.852 and 0.789 respectively in the patients older or equal to 60 and younger than 60 years.

Conclusion

The ascitic endocan level is an independent risk factor for SBP in patients with cirrhotic ascites

and may serve as a valuable biomarker for diagnosis of SBP

especially in those aged 60 or older.

关键词

Keywords

references

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