少突胶质细胞及髓鞘形成参与学习记忆功能的研究进展

姚忠祥; 胡波

doi:10.16016/j.1000-5404.202002018

您当前的位置：

首页 >

文章列表页 >

少突胶质细胞及髓鞘形成参与学习记忆功能的研究进展

神经科学 | 更新时间：2026-01-09

- 少突胶质细胞及髓鞘形成参与学习记忆功能的研究进展
- Advances of oligodendrocytes and myelination involving in learning and memory
- 第三军医大学学报 2020年42卷第9期页码：887-890
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)基础医学院生理学教研室
- 作者简介：
  
  [ "姚忠祥, 博士, 教授, 博士研究生导师。主持国家自然科学基金、重庆市创新基金重点项目等10余项。享受国家政府特殊津贴专家, 获得中国人民解放军院校育才银奖。以通信作者在Molecular Neurobiology等国际刊物发表论文30篇。主要从事学习记忆与认知障碍的髓鞘机制方面的研究。E-mail: yaozhx@yahoo.com" ]
  [ "胡波, 博士, 副教授, 硕士研究生导师。主持国家自然科学基金、军委科技委国防创新特区项目、重庆市自然科学基金等科研项目6项。以主要作者身份在Nature Neuroscience、Neuron、Neuroscience and Biobehavioral Reviews等国际刊物发表论文10余篇。主要从事觉醒睡眠与学习记忆功能方面的研究。E-mail: bohu@tmmu.edu.cn" ]
- 基金信息：
  
  国家自然科学基金面上项目(31371147);重庆市自然科学基金面上项目(CSTC2019jcyj-msxmX0424)
- DOI：10.16016/j.1000-5404.202002018
  中图分类号： R322.81;R338.64
- 收稿：2020-02-04，
  
  修回：2020-02-16，
  
  纸质出版：2020-05-15
- 稿件说明：
移动端阅览
姚忠祥, 胡波. 少突胶质细胞及髓鞘形成参与学习记忆功能的研究进展[J]. 第三军医大学学报, 2020,42(9):887-890.

Zhongxiang YAO, Bo HU. Advances of oligodendrocytes and myelination involving in learning and memory[J]. Journal of Third Military Medical University, 2020, 42(9): 887-890.
姚忠祥, 胡波. 少突胶质细胞及髓鞘形成参与学习记忆功能的研究进展[J]. 第三军医大学学报, 2020,42(9):887-890. DOI： 10.16016/j.1000-5404.202002018.

Zhongxiang YAO, Bo HU. Advances of oligodendrocytes and myelination involving in learning and memory[J]. Journal of Third Military Medical University, 2020, 42(9): 887-890. DOI： 10.16016/j.1000-5404.202002018.

摘要

神经元活性和学习活动可以调控成年少突胶质细胞的新生，但其功能意义尚不清楚。本文总结近一年来关于少突胶质细胞及髓鞘形成参与学习记忆功能的最新研究进展，探讨少突胶质细胞及髓鞘形成参与学习记忆功能的证据、少突胶质细胞基因表达变化与阿尔兹海默症病程的密切关系，以及少突胶质细胞及髓鞘形成引起学习记忆与认知障碍的药物治疗，并分析了现有研究的不足与未来发展趋势。

Abstract

Neuronal activity and learning can regulate the adult oligodendrogenesis. However

functional significance of this regulation remains not fully clear. Here

we reviewed the most recent progresses in the field of oligodendrocytes and myelination involved in learning and memory. Firstly

we introduce the evidence demonstrating that the oligodendrocytes and myelination are involved in learning and memory. Secondly

we show the gene expression changes of oligodendrocytes

which are closely associated with the progression of Alzheimer's disease. Third

we introduce a few of drug administration which are used to promote oligodendroglial differentiation and myelination and to rescue impairment of learning and memory. At last

we analyze the shortage of current research and propose the trend for future researches.

关键词

Keywords

references

STEADMAN P E, XIA F, AHM ED M, et al . Disruption of oligodendrogenesis impairs memory consolidation in adult mice[J ] . Neuron, 2020, 105(1): 150-164.e6. DOI:10.1016/j.neuron.2019.10.013.

DORON A, GOSHEN I. Glia: the glue holding memories together[J]. Neuron, 2020, 105(1): 9-11. DOI:10.1016/j.neuron.2019.12.016.

[WANG F, REN S Y, CHEN J F, et al . Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory[J ] . Nat Neurosci, 2020.[Epub ahead of print ] . DOI: 10.1038/s41593-020-0588-8 http://dx.doi.org/10.1038/s41593-020-0588-8 ..

HASAN M, KANNA M S, JUN W, et al . Schema-like learning and memory consolidation acting through myelination[J ] . FASEB J, 2019, 33(11): 11758-11775. DOI:10.1096/fj.201900910R.

HOLTER M C, HEWITT L T, KOEBELE S V, et al . The Noonan syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning[J ] . PLoS Genet, 2019, 15(4): e1008108. DOI:10.1371/journal.pgen.1008108.

ZHANG T T, CHEN P P, LI W, et al . Cognitive deficits in mice lacki ng Nsun5, a cytosine-5 RNA methyltransferase, with impairment of oligodendrocyte precursor cells[J ] . Glia, 2019, 67(4): 688-702. DOI:10.1002/glia.23565.

[PAN S, MAYORAL S R, CHOI H S, et al . Preservation of a remote fear memory requires new myelin formation[J ] . Nat Neurosci, 2020.[Epub ahead of print ] . DOI: 10.1038/s41593-019-0582-1 http://dx.doi.org/10.1038/s41593-019-0582-1 ..

ZHOU Y Y, SONG W M, ANDHEY P S, et al . Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease[J ] . Nat Med, 2020, 26(1): 131-142. DOI:10.1038/s41591-019-0695-9.

MATHYS H, DAVILA-VELDERRAIN J, PENG Z Y, et al . Single-cell transcriptomic analysis of Alzheimer's disease[J ] . Nature, 2019, 570(7761): 332-337. DOI:10.1038/s41586-019-1195-2.

DOS SANTOS N, NOVAES L S, DRAGUNAS G, et al . High dose of dexamethasone protects against EAE-induced motor deficits but impairs learning/memory in C57BL/6 mice[J ] . Sci Rep, 2019, 9(1): 6673. DOI:10.1038/s41598-019-43217-3.

INABA T, MIYAMOTO N, HIRA K, et al . Protective role of levetiracetam against cognitive impairment and brain white matter damage in mouse prolonged cerebral hypoperfusion[J ] . Neuroscience, 2019, 414: 255-264. DOI:10.1016/j.neuroscience.2019.07.015.

VENKAT P, CHOPP M, ZACHAREK A, et al . Sildenafil treatment of vascular dementia in aged rats[J ] . Neurochem Int, 2019, 127: 103-112. DOI:10.1016/j.neuint.2018.12.015.

WANG G H, DING L Z, GAO C Y, et al . Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice[J ] . Neuropharmacology, 2019, 146: 39-49. DOI:10.1016/j.neuropharm.2018.11.025.

JIANG R L, PRELL C, LÖNNERDAL B. Milk osteopontin promotes brain development by up-regulating osteopontin in the brain in early life[J]. FASEB J, 2019, 33(2): 1681-1694. DOI:10.1096/fj.201701290RR.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

颈深淋巴-静脉吻合术治疗阿尔茨海默病的病例系列报道

缺血性深部脑白质损害患者认知障碍和静息态功能磁共振成像研究

侧脑室注射miR-219激动剂对脂多糖所致新生大鼠少突胶质细胞成熟障碍的影响

非侵入式静电场刺激对脂多糖诱导神经认知障碍小鼠的改善作用

膜联蛋白A6促进神经祖细胞定向少突胶质细胞分化发育的机制研究