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7 829例疑似强直性脊柱炎患者HLA-B27抗原阳性率及分型研究
Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis
- 第三军医大学学报 2020年42卷第12期 页码：1220-1224
- 作者机构：
400038 重庆, 陆军军医大学(第三军医大学)第一附属医院风湿免疫科
- 作者简介：
[王勇, E-mail:wangyongjhy@126.com WANG Yong, E-mail:wangyongjhy@126.com
- 基金信息：
DOI：10.16016/j.1000-5404.202001204
中图分类号： R195.4;R392.11;R593.23收稿：2020-01-30，
修回：2020-03-22，
纸质出版：2020-06-30
- 稿件说明：
移动端阅览
高乐女, 吴红, 游苘霞, 等. 7 829例疑似强直性脊柱炎患者HLA-B27抗原阳性率及分型研究[J]. 第三军医大学学报, 2020,42(12):1220-1224.
Lenyu GAO, Hong WU, Qingxia YOU, et al. Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis[J]. Journal of Third Military Medical University, 2020, 42(12): 1220-1224.
高乐女, 吴红, 游苘霞, 等. 7 829例疑似强直性脊柱炎患者HLA-B27抗原阳性率及分型研究[J]. 第三军医大学学报, 2020,42(12):1220-1224. DOI： 10.16016/j.1000-5404.202001204.
Lenyu GAO, Hong WU, Qingxia YOU, et al. Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis[J]. Journal of Third Military Medical University, 2020, 42(12): 1220-1224. DOI： 10.16016/j.1000-5404.202001204.
摘要
目的
2
通过对重庆地区疑似强直性脊柱炎(ankylosing spondylitis
AS)的患者及部分亲属的人类白细胞表面抗原-B27(HLA-B27)阳性情况进行分析
了解该抗原不同表型在本地区疑似患者中分布的差异。
方法
2
回顾性分析本院2018年1月1日至2019年11月29日诊治的重庆地区7 829例疑似AS的患者及部分亲属的临床资料
采用序列特异性引物聚合酶链反应(PCR-SSP)法检测血液标本所得的HLA-B27基因亚型的分型情况。
结果
2
7 829例数据中HLA-B27抗原阳性有2 112例
阳性率为26.98%;其中男性阳性率显著高于女性(33.87%
vs
18.58%
P
<
0.01)。其中B* 2704型有1 655例(78.36%)
B*2705/07型有358例(16.95%)。有46例HLA-B27阳性者合并眼部疾病
其中B* 2704型有36例(78.26%)
并且以葡萄膜炎多见(34/46)。
结论
2
重庆地区人群AS疑似病例HLA-B27抗原阳性率男性明显高于女性。HLA-B27亚型以B* 2704、B* 2705/07为主
且前者是重庆地区AS的发病易感基因亚型。AS合并眼部疾病者以葡萄膜炎多见
HLA-B27基因亚型以B* 2704型为主。
Abstract
Objective
2
To analyze the positivity of human leukocyte surface antigen-B27 (HLA-B27) in patients with suspected ankylosing spondylitis (AS) and their relatives in Chongqing to understand the gender-specific distribution of HLA-B27 genotypes in the patients.
Methods
2
We retrospectively analyzed the clinical data of 7 829 patients with suspected AS and some of their relatives
who were diagnosed in Chongqing between January 1
2018 and November 29
2019. HLA-B27 genotypes were determined using a sequence-specific primer polymerase chain reaction (PCR-SSP).
Results
2
Of the 7 829 patients
2 112 were positive for HLA-B27 antigen
with a positive rate of 26. 98%. The positive rate of HLA-B27 antigen was significantly higher in the male than in the female patients (33.87%
vs
18.58%
P
<
0.01). A total of 1 655 (78. 36%) patients had a B* 2704 genotype and 358 (16.95%) had a B* 2705/07 genotype of HLA-B27 antigen. Forty-six of the HLA-B27-positive patients were found to have ocular diseases
among whom 36 (78.26%) patients had a B* 2704 genotype; uveitis was the most frequent ocular disease in these patients (34/46).
Conclusion
2
The patients with suspected AS in Chongqing have a significantly higher rate HLA- B27 antigen positivity than the normal population
and the positive rate is significantly higher in male than in female patients. The HLA-B27 genotypes are predominantly B * 2704 and B * 2705/07
and the former is associated with AS susceptibility. Uveitis is common in HLA-B27-positive AS patients with ocular diseases
who have a predominant B * 2704 genotype.
关键词
Keywords
references
刘彧.强直性脊柱炎免疫遗传学发病机制的研究进展[J].中国临床医学, 2019, 26(1): 117-121. DOI: 10.12025/j.issn.1008-6358.2019.20180712.
LIU Y.Research progress of immunogenetic pathogenesis of ankylosing spondylitis[J]. Chin J Clin Med, 2019, 26(1): 117-121. DOI:10.12025/j.issn.1008-6358.2019.20180712.
丁繁荣, 姜萍, 刘巍.强直性脊柱炎发病机制的研究进展[J].山东医药, 2019, 59(17): 102-105. DOI: 10.3969/j.issn.1002- 266X.2019.17.029.
DING F R, JIANG P, LIU W. Research progress in the pathogenesis of ankylosing spondylitis[J]. Shandong Med J, 2019, 59(17): 102-105. DOI: 10.3969/j.issn.1002-266X. 2019.17.029.
何少娟, 蔡昭炜. HLA-B27基因表达变化对强直性脊柱炎发生的影响[J].四川医学, 2019, 40(8): 807-810. DOI: 10.16252/j.cnki.issn!004-0501-2019.08.011.
HE S J, CAI Z W. Effect of HLA-B27 gene expression changes on the occurrence of ankylosing spondylitis[J]. Sichuan Med J, 2019, 40(8): 807-810. DOI: 10.16252/j.cnki.issn!004-0501-2019.08.011.
SMITH J A. Update on ankylosing spondylitis: current concepts in pathogenesis[J]. Curr Allergy Asthma Rep, 2015, 15(1): 489. DOI: 10.1007/s11882-014-0489-6.
BREWERTON D A, HART F D, NICHOLLS A, et al . Ankylosing spondylitis and HL-A 27[J ] . Lancet, 1973, 1(7809): 904-907.
刘持翔, 刘冬冬, 黄常健.中国人群HLA-B*27基因亚型与强直性脊柱炎的相关性研究[J].医疗装备, 2019, 32(11): 190-193. DOI: 10.3969/j.issn.1002-2376.2019.11.119.
LIU C X, LIU D D, HUANG C J. Correlation study of the relationship between HLA-B*27 gene subtype and ankylosing spondylitis in Chinese population[J]. Med Equip, 2019, 31(11): 190-193. DOI: 10.3969/j.issn.1002-2376.2019.11.119.
RASHID T, WILSON C, EBRINGER A. Raised incidence of ankylosing spondylitis among Inuit populations could be due to high HLA-B27 association and starch consumption[J]. Rheumatol Int, 2015, 35(6): 945-951. DOI: 10.1007/s00296- 014-3164-2.
白世杰, 托娅, 张保平, 等.流式细胞术与PCR-SSP法检测HLA-B27的比对及HLA-B27亚型的研究[J].检验医学与临床, 2016, 13(5): 586-587. DOI: 10.3969/j.issn.1672-9455.2016.05.004.
BAI S J, TUO Y, ZHANG B P, et al . Comparison of HLA-B27 detection by flow cytometry and SSPP-PCR and study on HLA-B27 subtype[J ] . Lab Med Clin, 2016, 13(5): 586-587. DOI: 10.3969/j.issn.1672-9455.2016.05.004.
VAN DER LINDEN S, VALKENBURG HA, CATS A.Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria[J]. Arthr Rheum, 1984, 27(4): 361-368. DOI: 10.1002/art.1780270401.
胡劲涛, 柴乐, 任伟凡, 等.强直性脊柱炎骨代谢的研究进展[J].中国骨质疏松杂志, 2019, 25(6): 875-879. DOI: 10.3969/j.issn.1006-7108.2019.06.031.
HU J T, CAI L, REN W F, et al .Progress on research of bone metabolism in ankylosing spondylitis[J ] . Chi J Osteoporos, 2019, 25(6): 875-879. DOI: 10.3969/j.issn.1006-7108.2019.06.031.
沈逸, 何东仪.强直性脊柱炎新骨形成机制和研究现状[J].现代免疫学, 2017, 37(2): 142-145.
SHEN Y, HE D Y. Mechanism and research status on new bone formation of ankylosing spondylitis[J]. Curr Immunol, 2017, 037(002): 142-145.
周海兵, 罗志军, 陈庆军, 等.人工全髋关节置换术治疗强直性脊柱炎中期、远期疗效观察[J].浙江中西医结合杂志, 2018, 28(11): 947-949.
ZHOU H B, LUO Z J, CHEN Q J, et al . The mid and long term effect of total hip arthroplasty on ankylosing spondylitis[J ] . Zhejiang J Integr Chin Western Med, 2018, 28(11): 947-949.
徐胜前, 黄烽.应重视中轴型脊柱关节炎的达标治疗[J].中华内科杂志, 2019, 58(10): 705-708. DOI: 10.3760/cma.j.issn.0578-1426.2019.10.001.
XU S Q, HUANG F. Attention should be paid to the standard treatment of axial spondyloarthroarthritis [J]. Chin J Intern Med, 2019, 58(10): 705-708. DOI: 10.3760/cma.j.issn.0578- 1426.2019.10.001.
BROWN M A, KENNA T, WORDSWORTH B P. Genetics of ankylosing spondylitis: insights into pathogenesis[J]. Nat Rev Rheumatol, 2016, 12(2): 81-91. DOI: 10.1038/nrrheum. 2015.133.
CHEN B, LI J, HE C R, et al . Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review)[J ] . Mol Med Rep, 2017, 15(4): 1943-1951. DOI: 10.3892 /mmr.2017.6248.
VAN DER HEIJDE D, BRAUN J, DEODHAR A, et al . Modified stoke ankylosing spondylitis spinal score as an outcome measure to assess the impact of treatment on structural progression in ankylosing spondylitis[J ] . Rheumatology (Oxford), 2019, 58(3): 388-400. DOI: 10.1093/rheumatology/key128.
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