癌症复发恐惧的乳腺癌幸存者静息态脑功能成像研究

彭李; 徐松; 胡晓飞; 薛源; 李敏

doi:10.16016/j.1000-5404.201912294

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癌症复发恐惧的乳腺癌幸存者静息态脑功能成像研究

基础医学 | 更新时间：2026-01-09

- 癌症复发恐惧的乳腺癌幸存者静息态脑功能成像研究
- Resting brain functional imaging of breast cancer survivors with fear of cancer recurrence based on ReHo method
- 第三军医大学学报 2020年42卷第11期页码：1150-1154
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201912294
  中图分类号：
- 收稿：2019-12-31，
  
  纸质出版：2020-06-15
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彭李, 徐松, 胡晓飞, 等. 癌症复发恐惧的乳腺癌幸存者静息态脑功能成像研究[J]. 第三军医大学学报, 2020,42(11):1150-1154.

Li PENG, Song XU, Xiaofei HU, et al. Resting brain functional imaging of breast cancer survivors with fear of cancer recurrence based on ReHo method[J]. Journal of Third Military Medical University, 2020, 42(11): 1150-1154.
彭李, 徐松, 胡晓飞, 等. 癌症复发恐惧的乳腺癌幸存者静息态脑功能成像研究[J]. 第三军医大学学报, 2020,42(11):1150-1154. DOI： 10.16016/j.1000-5404.201912294.

Li PENG, Song XU, Xiaofei HU, et al. Resting brain functional imaging of breast cancer survivors with fear of cancer recurrence based on ReHo method[J]. Journal of Third Military Medical University, 2020, 42(11): 1150-1154. DOI： 10.16016/j.1000-5404.201912294.

摘要

Abstract

Objective

To investigate the characteristics of resting brain function in breast cancer survivors with fear of cancer recurrence.

Methods

A total of 59 breast cancer survivors were recruited by voluntary enrollment from Department of Breast and Thyroid Surgery

First Affiliated Hospital

Army Medical University during May and July 2017

and were divided into the low fear of cancer recurrence group (

=28) and high fear group (

=31) according to the results of Fear of Cancer Recurrence Inventory (FCRI). Their resting brain functional images were collected

and the differences of mean brain regional homogeneity (ReHo) map were compared between the 2 groups so as to i

nvestigate the consistency of spontaneous neuron activities in the brain.

Results

Compared to the low fear group

the ReHo value was increased in the left caudate nucleus and was decreased in the right anterior cuneiform lobe in the high fear group (

0.01). The value in the left caudate nucleus was negatively correlated with the total score of FCR (

=-0.501

0.05)

and that in the right anterior cuneiform lobe was positively with the total score (

=0.505

0.05).

Conclusion

Fear of cancer recurrence has significant effects on the consistency of spontaneous neuron activity in the left caudate nucleus and the right anterior cuneiform lobe in resting state

which may be related to the change of emotion and cognitive function of breast cancer survivors.

关键词

Keywords

references

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