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二维斑点追踪成像评价低温条件下兔左心室收缩功能改变
Evaluation of rabbit left ventricular systolic function at low temperature by two-dimensional speckle-tracking echocardiography
- 第三军医大学学报 2020年42卷第11期 页码：1086-1090
- 作者机构：
- 作者简介：
- 基金信息：全军“十二五”课题面上项目(CSY13J005)
DOI：10.16016/j.1000-5404.201912187
中图分类号：收稿：2019-12-19，
纸质出版：2020-06-15
- 稿件说明：
移动端阅览
王冬妮, 曹军英, 吴璐璐, 等. 二维斑点追踪成像评价低温条件下兔左心室收缩功能改变[J]. 第三军医大学学报, 2020,42(11):1086-1090.
Dongni WANG, Junying CAO, Lulu WU, et al. Evaluation of rabbit left ventricular systolic function at low temperature by two-dimensional speckle-tracking echocardiography[J]. Journal of Third Military Medical University, 2020, 42(11): 1086-1090.
王冬妮, 曹军英, 吴璐璐, 等. 二维斑点追踪成像评价低温条件下兔左心室收缩功能改变[J]. 第三军医大学学报, 2020,42(11):1086-1090. DOI： 10.16016/j.1000-5404.201912187.
Dongni WANG, Junying CAO, Lulu WU, et al. Evaluation of rabbit left ventricular systolic function at low temperature by two-dimensional speckle-tracking echocardiography[J]. Journal of Third Military Medical University, 2020, 42(11): 1086-1090. DOI： 10.16016/j.1000-5404.201912187.
摘要
Abstract
Objective
2
To investigate the change of left ventricular systolic function in rabbits at low temperature by using two-dimensional speckle-tracking technique.
Methods
2
Thirty New Zealand rabbits were randomly and equally divided into control group
hypothermia for 4 h(group A) and for 8 h(group B) groups. After routine cardiac measurements were performed firstly
then tissue Doppler imaging (TDI) was carried out to record peaks in the S
E and Aspectra of the septal side of the mitral valve
followed by speckle-tracking imaging (STI) to obtain global peak longitudinal strain (SL)
circumferential strain (SC) and radial strain (SR)
and the peak values in the basal
medium and apical segments. The indexes of myocardial enzyme spectrum were detected by hematology
and the changes of myocardial pathology were observed by HE staining.
Results
2
Significant differences were seen in the conventional ultrasound parameters
such as left ventricular end-systolic diameter (LAESd)
left ventricular end-diastolic diameter (LVEDd)
left ventricular ejection fraction (LVEF)
peak systolic velocity (Sm)
peak early diastolic velocity (Em)
and peak end diastolic velocity (Am) between the control group and group B(
P
<
0.05). Compared with the control group
the global SL
SC and SR and the values in apical segment were obviously decreased in group A
and the above global values and those in basal
medium and apical segments were all reduced in group B(
P
<
0.05). The global SL and SR values and those in the 3 segments were notably lower in group Bthan group A(
P
<
0.05). The serum levels of aspartate aminotransferase (AST)
creatine kinase (CK)
creatine kinase isozyme (CK-MB)
and high-sensitivity cardiac troponin T(HS-TNT) were significantly increased in groups Aand Bthan the control group (
P
<
0.05). HE staining showed that partially broken myocardial fibers
disintegrated cardiomyocytes
dissolved nuclei
lightly stained chromatin
and Alot of inflamma
tory cells were seen in group B.
Conclusions
2
With the extension of low temperature time
the myocardial tissue shows damage at different degrees. Two-dimensional speckle-tracking technology can find declined left ventricular function earlier than LVEF and TDI.
关键词
Keywords
references
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