医学3D打印多孔钽在骨科的应用

杨柳; 王富友

doi:10.16016/j.1000-5404.201908136

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医学3D打印多孔钽在骨科的应用

专家述评 | 更新时间：2026-01-09

- 医学3D打印多孔钽在骨科的应用
- Progress of 3D printed porous tantalum in orthopedics
- 第三军医大学学报 2019年41卷第19期页码：1859-1866
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)第一附属医院关节外科
- 作者简介：
  
  [杨柳，博士，主任医师，教授，博士生导师，国家“十三五”增材制造重点研发专项和国家自然科学基金重点项目首席科学家。担任国际软骨修复学会(ICRS)中国部常务委员, 国际华人骨研学会终生会员，中国名医百强榜(骨关节外TOP10DR)第1名，中华医学会运动医疗分会委员，中国医师协会骨科委员会关节外科工作委员会常务委员, 中国医疗器械行业协会3D打印医疗器械专业委员会专家，中国医疗器械行业协会团体标准《3D打印多孔钽临床应用标准》起草负责人；中国生物材料学会骨修复材料与器械分会副主任委员，重庆市首席医学专家，重庆市生物医学工程学会常务理事，重庆市增材制造产业协会医学3D打印分会会长。主持国家自然科学基金重点项目1项，面上项目4项；国家重点研发计划1项；担任国家自然科学基金杰青、重点、面上、青年项目评审专家，教育部长江学者评审专家等。获得授权和申请国家发明专利、实用新型专利共59件。发表论文281篇，其中SCI收录52篇，主、参编国内外专著26部。主要从事运动医学与骨关节外科方面的研究。E-mail:jointsurgery@163.comYANG Liu, E-mail:jointsurgery@163.com
- 基金信息：
  
  国家重点研发计划(2016YFB1101400)
- DOI：10.16016/j.1000-5404.201908136
  中图分类号： R318.08;R68
- 收稿：2019-08-18，
  
  修回：2019-09-04，
  
  纸质出版：2019-10-15
- 稿件说明：
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杨柳, 王富友. 医学3D打印多孔钽在骨科的应用[J]. 第三军医大学学报, 2019,41(19):1859-1866.

Liu YANG, Fuyou WANG. Progress of 3D printed porous tantalum in orthopedics[J]. Journal of Third Military Medical University, 2019, 41(19): 1859-1866.
杨柳, 王富友. 医学3D打印多孔钽在骨科的应用[J]. 第三军医大学学报, 2019,41(19):1859-1866. DOI： 10.16016/j.1000-5404.201908136.

Liu YANG, Fuyou WANG. Progress of 3D printed porous tantalum in orthopedics[J]. Journal of Third Military Medical University, 2019, 41(19): 1859-1866. DOI： 10.16016/j.1000-5404.201908136.

摘要

钽具有“亲生物”金属之称，具有极佳的生物惰性和生物相容性。纯钽应用于骨科医疗至今已经80多年。由于纯钽与骨组织弹性模量相差较大，不利于骨结合，然而多孔钽却在提供力学强度的同时可减少应力遮挡，有利于应力传导，便于骨骼塑形，同时具有优良的骨诱导性，广泛应用于骨科领域，并取得了理想疗效。但是由于人体的差异性、骨缺损部位形态的随机性，如骨肿瘤患者、骨畸形患者等，标准化多孔钽已经不能满足患者个性化治疗要求。从临床医学发展趋势看，最好的治疗方法应该是个性化治疗，最好的植入体应该是个性化植入体。未来需要解决钽粉原材料及价格、专用设备及工艺、3D打印工艺与传统工艺的差异、多组分梯度打印等方面的问题。

Abstract

Tantalum

known as "pro-biometal"

has excellent bio-inertness and bio-compatibility. Pure tantalum has been used in orthopedics for longer than 80 years. But pure tantalum has little in common with bone tissue in the elastic modulus and is not conducive to osseointegration

while

porous tantalum can not only provide mechanical strength but also reduce stress occlusion

facilitate stress conduction

promote bone shaping

and has excellent osteoinduction

which is widely used in orthopedics and has achieved ideal outcomes. However

due to great diversities in human body and randomness of bone defect sites

such as patients with bone tumors and those with bone deformities

standardized porous tantalum is unable to meet the patients' individualized treatment requirements. From the perspective of clinical development

the optional treatment should be individualized

and the best implant should also be individualized. In the future

we need to focus on the following problems

tantalum powder and its price

special equipment and manufacturing process

differences between 3D and traditional manufacure

and multicomponent gradients and others.

关键词

Keywords

references

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