具核梭杆菌研究进展

毛旭虎; 童亚楠

doi:10.16016/j.1000-5404.201908133

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具核梭杆菌研究进展

专家述评 | 更新时间：2026-01-09

- 具核梭杆菌研究进展
- Progress in Fusobacterium nucleatum
- 第三军医大学学报 2019年41卷第19期页码：1867-1872
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)药学与检验医学系临床微生物与免疫学教研室
- 作者简介：
  
  [毛旭虎，博士，教授，博士生导师。担任中国微生物学会医学微生物与免疫学专委会委员兼细菌学组副组长，全军微生物专委会及生物军控与履约专委会委员，重庆市微生物学会常务理事兼临床微生物专委会主任委员，重庆市免疫学会理事兼免疫诊断专委会主任委员。主持国家“863”、重大新药创制专项，军队特需药专项，国家自然科学基金等20余项课题。获得国家发明专利22项，国家发明二等奖1项，军队科技进步二等奖2项，重庆市技术发明一等奖1项，首届中国药学会青年生物药物奖, 被评为总后科技新星，中组部万人计划科技创新领军人才。在SCI收录杂志发表论文40余篇，主要从事重要病原微生物防控方面的研究。E-mail:maoxh2012@hotmai.comMAO Xuhu, E-mail: maoxh2012@hotmail.com
- 基金信息：
- DOI：10.16016/j.1000-5404.201908133
  中图分类号： R378.99
- 收稿：2019-08-18，
  
  修回：2019-09-01，
  
  纸质出版：2019-10-15
- 稿件说明：
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毛旭虎, 童亚楠. 具核梭杆菌研究进展[J]. 第三军医大学学报, 2019,41(19):1867-1872.

Xuhu MAO, Yanan TONG. Progress in Fusobacterium nucleatum[J]. Journal of Third Military Medical University, 2019, 41(19): 1867-1872.
毛旭虎, 童亚楠. 具核梭杆菌研究进展[J]. 第三军医大学学报, 2019,41(19):1867-1872. DOI： 10.16016/j.1000-5404.201908133.

Xuhu MAO, Yanan TONG. Progress in Fusobacterium nucleatum[J]. Journal of Third Military Medical University, 2019, 41(19): 1867-1872. DOI： 10.16016/j.1000-5404.201908133.

摘要

具核梭杆菌(

Fusobacterium nucleatum

nucleatum

)是口腔微生物群中常驻成员，并且可以与其宿主产生共生关系。具核梭杆菌能够引起多种机会性感染。最近的研究发现其感染与结直肠癌的发生、发展密切相关。现就具核梭杆菌与宿主的共生关系、作为感染因子在疾病中的角色，以及促进肿瘤进程的作用等方面进行评述，并深入探讨目前对该菌的一些新见解和未来的研究方向。这些新观点希望可以帮助我们不断认识具核梭杆菌及其促进结直肠癌作用的新机制，为寻找具核梭杆菌诊断与治疗的新方法提供依据。

Abstract

Fusobacterium nucleatum

(

nucleatum

) is one of the resident members in oral microflora

and has a symbiotic relationship with the host.

nucleatum

can cause a variety of opportunistic infections

and many recent studies have linked it to the occurrence and development of colorectal cancer. In this paper

we review the symbiotic relationship between

nucleatum

and its host

and its roles as an infectious factor in disease and as a promoter for tumor progress. In addition

some new views and future research directions of this bacterium are also discussed. We hope that these new ideas will help us understand the role of

nucleatum

in promoting colorectal cancer and the related mechanisms

as well as provide a basis for new methods in the diagnosis and treatment of

nucleatum

associated colorectal cancer.

关键词

Keywords

references

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