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自体造血干细胞移植期间腹泻患者艰难梭菌感染及其影响因素分析
Incidence and risk factors for
Clostridium difficile infection in patients with diarrhea during autologous hematopoietic stem cell transplantation- 第三军医大学学报 2019年41卷第23期 页码：2285-2289
- 作者机构：
- 作者简介：
- 基金信息：
DOI：10.16016/j.1000-5404.201907204
中图分类号：收稿：2019-07-26，
纸质出版：2019-12-25
- 稿件说明：
移动端阅览
毛蕾, 夏冰, 田晨, 等. 自体造血干细胞移植期间腹泻患者艰难梭菌感染及其影响因素分析[J]. 第三军医大学学报, 2019,41(23):2285-2289.
Lei MAO, Bing XIA, Chen TIAN, et al. Incidence and risk factors for
Clostridium difficile infection in patients with diarrhea during autologous hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2019, 41(23): 2285-2289.毛蕾, 夏冰, 田晨, 等. 自体造血干细胞移植期间腹泻患者艰难梭菌感染及其影响因素分析[J]. 第三军医大学学报, 2019,41(23):2285-2289. DOI： 10.16016/j.1000-5404.201907204.
Lei MAO, Bing XIA, Chen TIAN, et al. Incidence and risk factors for
Clostridium difficile infection in patients with diarrhea during autologous hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2019, 41(23): 2285-2289. DOI： 10.16016/j.1000-5404.201907204.
摘要
Abstract
Objective
2
To investigate the incidence and risk factors for
Clostridium difficile
infection (CDI) in patients with diarrhea during autologous hematopoietic stem cell transplantat
ion (auto-HSCT) and provide guidance for clinical diagnosis and treatment.
Methods
2
Clinical data of patients with diarrhea during auto-HSCT between May 2005 and July 2019 were collected and retrospectively analyzed. The patients with positive results of
Clostridium difficile
anaerobic culture and
Clostridium difficile
toxin A/B test were assigned into the CDI group
and the others were into the non-CDI group. The incidence and risk factors for CDI were analyzed in this case-control study.
Results
2
A total of 202 patients developed diarrhea during auto-HSCT in this study. Thirty-three patients suffered from CDI
with an incidence rate of 16.3% and a median onset of 12(8~17) d since the admission of transplantation ward. The results of the univariate analysis indicated that the incidence of CDI was associated with the administration of busulfan
bortezomib and carmustine (all
P
<
0.05). The multivariate analysis showed that busulfan and bortezomib were the independent risk factors for CDI (all
P
<
0.05). The median time of diarrhea was 6(4~9) d in CDI patients
and 2 patients (6.0%) developed septic shock and died.
Conclusion
2
The incidence rate of CDI is quite high in the patients with diarrhea during auto-HSCT. The administration of busulfan and bortezomib are risk factors for CDI.
关键词
Keywords
references
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