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经颅超声结合磁敏感加权成像技术在帕金森综合征诊断中的应用
Combination of transcranial ultrasound and susceptibility weighted imaging in diagnosis of Parkinsonism
- 第三军医大学学报 2020年42卷第1期 页码：25-30
- 作者机构：
1.400016 重庆，重庆医科大学附属第二医院超声科，超声分子影像重庆市重点实验室
2.400014 重庆，中国科学院大学重庆医院，重庆市人民医院超声科
- 作者简介：
[李奇林，E-mail: 26879139@qq.com LI Qilin, E-mail: 26879139@qq.com
- 基金信息：重庆市卫生计生委医学科研计划面上项目(2017MSXM054)
DOI：10.16016/j.1000-5404.201907201
中图分类号： R445.1;R742.5收稿：2019-07-26，
修回：2019-09-29，
纸质出版：2020-01-15
- 稿件说明：
移动端阅览
张存程, 凌镜, 黄莺, 等. 经颅超声结合磁敏感加权成像技术在帕金森综合征诊断中的应用[J]. 第三军医大学学报, 2020,42(1):25-30.
Cuncheng ZHANG, Jing LING, Ying HUANG, et al. Combination of transcranial ultrasound and susceptibility weighted imaging in diagnosis of Parkinsonism[J]. Journal of Third Military Medical University, 2020, 42(1): 25-30.
张存程, 凌镜, 黄莺, 等. 经颅超声结合磁敏感加权成像技术在帕金森综合征诊断中的应用[J]. 第三军医大学学报, 2020,42(1):25-30. DOI： 10.16016/j.1000-5404.201907201.
Cuncheng ZHANG, Jing LING, Ying HUANG, et al. Combination of transcranial ultrasound and susceptibility weighted imaging in diagnosis of Parkinsonism[J]. Journal of Third Military Medical University, 2020, 42(1): 25-30. DOI： 10.16016/j.1000-5404.201907201.
摘要
目的
2
研究帕金森综合征(Parkinsonism)人群利用经颅超声(transcranial ultrasound，TCS)发现中脑黑质回声增强(SN
+
)及磁敏感加权成像(susceptibility weighted imaging
SWI)发现“燕尾征”消失(loss of swallow tail sign，LSTS
+
)对帕金森病(Parkinson’s disease
PD)诊断的临床应用价值。
方法
2
以2016年7月至2018年12月在重庆市人民医院住院治疗的116例帕金森综合征患者为研究对象，其中62例为PD组，54例为非PD组。分析帕金森综合征人群中脑黑质TCS及SWI的图像特征，通过比较分别使用TCS发现SN
+
和SWI发现LSTS
+
，以及联合
使用以上两种方法诊断PD的敏感性与特异性和ROC曲线，研究TCS结合SWI在帕金森综合征诊断中的价值。
结果
2
PD患者SWI发现LSTS
+
及TCS发现SN
+
较非PD患者比例明显增高，以SN
+
与LSTS
+
为指标诊断帕金森病的敏感性、特异性、曲线下面积分别为80.6%、66.7%、0.737和88.7%、64.8%、0.768，联合应用两种指标诊断PD的敏感性、特异性、曲线下面面积分别为71.0%、88.9%、0.809。
结论
2
帕金森综合征患者人群中，使用TCS和SWI的结果为指标诊断PD的效能相似，但使用TCS的经济性与便捷性更佳，联合两种指标较单一指标诊断PD的敏感性下降，特异性有所提高。
Abstract
Objective
2
To analyze the diagnostic value of combination of transcranial ultrasound (TCS) found substantia nigra hyperechogenicity (SN
+
) and susceptibility weighted imaging (SWI) found loss of "swallow tail sign" (LSTS
+
) to diagnose parkinsonism
and assess the clinical value of TCS and SWI in the diagnosis of Parkinson's disease (PD).
Methods
2
A total of 116 patients with parkinsonism admitted the Chongqing People's Hospital from July 2016 to December 2018 were recruited in this study. And 62 of them were in the PD group and 54 in the non-PD group. The image features of TCS for nigra and SWI were analyzed in these parkinsonism patients. With SN
+
found by TCS and LSTS
+
found by SWI as indicators
receiver operating characteristic (ROC) curve was used to analyze the sensitivity
specificity
and area under the curve (AUC) of the 2 examinations alone or combined together in diagnosis of PD.
Results
2
There were more patients with SN
+
by TCS or LSTS
+
by SWI in the PD patients than the non-PD patients. The sensitivity
specificity and AUC of diagnosis of by using SN
+
and LSTS
+
to diagnose PD were 80.6%
66.7%
0.737 and 88.7%
64.8%
0.768
respectively. However
the sensitivity and specificity and AUC of their combination for the diagnosis were 71.0%
88.9%
and 0.809.
Conclusion
2
In patients with parkinsonism
the results of TCS and SWI have similar efficacy in the diagnosis of PD
but TCS is better in economics and convenience. Although the sensitivity is decreased when the 2 examinations combine together
the specificity is greatly improved.
关键词
Keywords
references
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