质子泵抑制剂联合强化饮食干预治疗咽喉反流性疾病的有效性研究

王敏; 李谦; 包小敏; 张焱; 冯筱青; 邓梦惠; 周朗朗; 邓安春

doi:10.16016/j.1000-5404.201907010

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质子泵抑制剂联合强化饮食干预治疗咽喉反流性疾病的有效性研究

临床医学 | 更新时间：2026-01-09

- 质子泵抑制剂联合强化饮食干预治疗咽喉反流性疾病的有效性研究
- Efficacy of proton pump inhibitors combined with intensive diet intervention in treatment of laryngopharyngeal reflux disease
- 第三军医大学学报 2019年41卷第21期页码：2107-2113
- 作者机构：
  
  1.400037 重庆，陆军军医大学(第三军医大学)第二附属医院，耳鼻咽喉科
  2.400037 重庆，陆军军医大学(第三军医大学)第二附属医院，营养科
- 作者简介：
  
  [邓安春，E-mail:260019300@qq.comDENG Anchun, E-mail: 260019300@qq.com
- 基金信息：
- DOI：10.16016/j.1000-5404.201907010
  中图分类号： R459.3;R766.5;R975.6
- 收稿：2019-07-01，
  
  修回：2019-07-28，
  
  纸质出版：2019-11-15
- 稿件说明：
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王敏, 李谦, 包小敏, 等. 质子泵抑制剂联合强化饮食干预治疗咽喉反流性疾病的有效性研究[J]. 第三军医大学学报, 2019,41(21):2107-2113.

Min WANG, Qian LI, Xiaomin BAO, et al. Efficacy of proton pump inhibitors combined with intensive diet intervention in treatment of laryngopharyngeal reflux disease[J]. Journal of Third Military Medical University, 2019, 41(21): 2107-2113.
王敏, 李谦, 包小敏, 等. 质子泵抑制剂联合强化饮食干预治疗咽喉反流性疾病的有效性研究[J]. 第三军医大学学报, 2019,41(21):2107-2113. DOI： 10.16016/j.1000-5404.201907010.

Min WANG, Qian LI, Xiaomin BAO, et al. Efficacy of proton pump inhibitors combined with intensive diet intervention in treatment of laryngopharyngeal reflux disease[J]. Journal of Third Military Medical University, 2019, 41(21): 2107-2113. DOI： 10.16016/j.1000-5404.201907010.

摘要

目的

比较质子泵抑制剂(proton pump inhibitors

PPI)联合强化饮食干预对比单用质子泵抑制剂治疗咽喉反流疾病的有效性。

方法

将2017年1月至2018年1月在我院诊断为咽喉反流性疾病210例患者，分成强化饮食干预组(

=110)和标准饮食组(

=100)。强化饮食干预组采用规范化抑酸治疗联合强化饮食干预，而标准饮食组仅采用规范化抑酸治疗和普通饮食，两组均治疗12周。治疗前后采用反流症状指数量表(reflux symptom index，RSI)和反流体征评分量表(reflux finding score，RFS)进行评分。

结果

两组年龄、性别及治疗前RSI和RFS评分均无统计学差异。经过8周治疗，强化饮食干预组和标准饮食组均能有效改善患者RSI(

0.01)和RFS评分(

0.01)。与标准饮食组相比，强化饮食干预组能进一步降低RSI和RFS评分，特别在改善持续清嗓，痰过多或鼻涕倒流，饭后或躺下后咳嗽和烧心、胸痛、胃痛4个症状更为明显，差异有统计学意义(

0.05)。在总体有效率方面，治疗8周后，强化饮食干预组和标准饮食组有效率分别为73.07%和70.21%；治疗12周后，强化饮食干预组和标准饮食组有效率分别为83.67%和80.00%，但差异均无统计学意义。

结论

与单用PPI药物相比，PPI药物联合强化饮食干预能进一步改善咽喉反流性疾病患者的RSI和RFS评分，提高总体有效率。

Abstract

Objective

To compare the efficacy of proton pump inhibitors (PPI) combined with intensive diet intervention

PPI alone in the treatment of laryngopharyngeal reflux disease (LPRD).

Methods

A total of 210 patients diagnosed with LPRD in our hospital during January 2017 and January 2018 were recruited in this study

and were divided into PPI with intensive diet intervention group (PPI+diet group

=110) and PPI group (

=100). The PPI+diet group received standardized acid suppression therapy and intensified dietary intervention

while the PPI group only received standardized acid suppression therapy and sta

ndard diet. Both groups were treated for 12 weeks. Reflux symptom index (RSI) and reflux symptoms score (RFS) was used to evaluate the efficacy before and after treatment.

Results

There were no statistical differences in age

sex and RSI and RFS scores between the 2 groups. After 8 weeks of treatment

the RSI (

0.01) and RFS (

0.01) scores were significantly improved in both PPI plus diet group and PPI group. As compared with the PPI group

the PPI plus intensive diet group had lower RSI and RFS scores (

0.05)

especially in improving the symptoms of throat clearing

postnasal drip

cough and heartburn

chest pain and coughing post-eating or lying down. For the overall effective rate

the effective rate in PPI plus diet group and PPI group was 73.07% and 70.21% after 8 weeks of treatment

and the effective rate was improved to 83.67% and 80.00% after 12 weeks

although there were no significant differences.

Conclusion

Compared with PPI alone

PPI combined with intensive diet intervention can more significantly improve the RSI and RFS scores of LPRD patients with higher overall efficiency.

关键词

Keywords

references

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