脐带间充质细胞对异基因造血干细胞移植术后出血性膀胱炎的疗效及安全性分析

刘红云; 陈果; 曾韫璟; 张曦; 高力

doi:10.16016/j.1000-5404.201907007

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脐带间充质细胞对异基因造血干细胞移植术后出血性膀胱炎的疗效及安全性分析

专题报道：造血干细胞移植与细胞治疗 | 更新时间：2026-01-09

- 脐带间充质细胞对异基因造血干细胞移植术后出血性膀胱炎的疗效及安全性分析
- Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation
- 第三军医大学学报 2019年41卷第23期页码：2296-2300
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201907007
  中图分类号：
- 收稿：2019-07-02，
  
  纸质出版：2019-12-25
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刘红云, 陈果, 曾韫璟, 等. 脐带间充质细胞对异基因造血干细胞移植术后出血性膀胱炎的疗效及安全性分析[J]. 第三军医大学学报, 2019,41(23):2296-2300.

Hongyun LIU, Guo CHEN, Yunjing ZENG, et al. Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2019, 41(23): 2296-2300.
刘红云, 陈果, 曾韫璟, 等. 脐带间充质细胞对异基因造血干细胞移植术后出血性膀胱炎的疗效及安全性分析[J]. 第三军医大学学报, 2019,41(23):2296-2300. DOI： 10.16016/j.1000-5404.201907007.

Hongyun LIU, Guo CHEN, Yunjing ZENG, et al. Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2019, 41(23): 2296-2300. DOI： 10.16016/j.1000-5404.201907007.

摘要

Abstract

Objective

To investigate the efficiency and safety of the infusion of umbilical cord mesenchymal stromal cells (UCMSCs) for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods

Clinical data of patients with hemorrhages cystitis after allo-HSCT in our medical center from January 2014 to December 2018 were collected and analyzed retrospectively in this study. The duration of hemorrhagic cystitis

response rate and pain scores were compared between the patients undergoing UCMSCs infusion (

=28) and those without (

=24). The safety of the infusion was also observed.

Results

The UCMSCs infusion group had significantly higher overall response rate (100.0%

45.8%

0.05)

shorter median time of pain disappearance (20.6±13.5

33.9±21.7 d

0.05)

and shorter duration of hematuria macroscopically (26.3±14.8

38.9±24.0 d

0.05) and microscopically (31

.3±13.6

48.9±22.0 d

0.05) when compared the infusion group. Infusion of UCMSCs had no effect on the infection rates of blood cytomegalovirus and urinary BK virus.

Conclusion

Infusion of UCMSCs can significantly shorten the course of hemorrhagic cystitis

reduce pain

improve general prognosis

and have no side effect in the patients after allo-HSCT.

关键词

Keywords

references

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