替加环素对患者凝血指标影响的临床研究

张静; 张蓉

doi:10.16016/j.1000-5404.201903027

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替加环素对患者凝血指标影响的临床研究

临床医学 | 更新时间：2026-01-09

- 替加环素对患者凝血指标影响的临床研究
- Effect of tigecycline on coagulation markers: a retrospective study
- 第三军医大学学报 2019年41卷第15期页码：1485-1490
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201903027
  中图分类号：
- 收稿：2019-03-01，
  
  纸质出版：2019-08-15
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张静, 张蓉. 替加环素对患者凝血指标影响的临床研究[J]. 第三军医大学学报, 2019,41(15):1485-1490.

Jing ZHANG, Rong ZHANG. Effect of tigecycline on coagulation markers: a retrospective study[J]. Journal of Third Military Medical University, 2019, 41(15): 1485-1490.
张静, 张蓉. 替加环素对患者凝血指标影响的临床研究[J]. 第三军医大学学报, 2019,41(15):1485-1490. DOI： 10.16016/j.1000-5404.201903027.

Jing ZHANG, Rong ZHANG. Effect of tigecycline on coagulation markers: a retrospective study[J]. Journal of Third Military Medical University, 2019, 41(15): 1485-1490. DOI： 10.16016/j.1000-5404.201903027.

摘要

Abstract

Objective

To determine the effect of tigecyclin on coagulation markers in the patients taking it

and screen out the related risk factors.

Methods

A retrospective study was carried out on the patients with tigecycline treatment admitted to our hospital from January 2016 to December 2017 based on our hospital information system and the Meikang rational drug use monitoring system. Fibrinogen (FBG) level

prothrombin time (PT)

activated partial thromboplastin time (APTT)

thrombin time (TT)

platelet (PLT) count

glomerular filtration rate (eGFR)

and levels of alanine aminotransferase (ALT) and serum total bilirubin (TBIL) were compared before and after tigecycline administration. Finally

according to whether patients had abnormal coagulation indicators

Logistic regression was used to screen out high-risk factors of abnormal coagulation indexes caused by tigecycline.

Results

A total of 97 qualified cases were included in this study

including 69 males (71.1%) and 28 females (28.9%)

at a mean age of 56.93±19.31 years. Tigecycline treatment resulted in significantly decreased FBG level (

0.05) and prolonged PT

APTT and TT (

0.05)

but no such change was seen in PLT count. At the same time

there were no significant differences in ALT and TBIL levels before and after administration

and CRP and PCT showed significant differences (

0.05)

while WBC count showed no significant difference. The total WBC count

and CRP and PCT levels were decreased after administration

indicating the patients' infection status was improved. The eGFR value was remarkably improved (

0.05)

indicating better renal function. Logistic analysis showed that high dose of tigecycline was a risk factor for coagulopathy (

0.05

=3.96).

Conclusion

Tigecycline may cause decreased FBG

prolonged PT

APTT and TT

and the patients taking high dose tigecycline are prone to this adverse event.

关键词

Keywords

references

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