血清IgG及IgG4检测在ANCA相关性血管炎中的诊断价值

秦陈浩; 顾爱萍; 展富琴; 冯萍; 顾昊宇; 何春燕; 杨顺

doi:10.16016/j.1000-5404.201902006

您当前的位置：

首页 >

文章列表页 >

血清IgG及IgG4检测在ANCA相关性血管炎中的诊断价值

临床医学 | 更新时间：2026-01-09

- 血清IgG及IgG4检测在ANCA相关性血管炎中的诊断价值
- Diagnostic value of serum IgG and IgG4 in antineutrophil cytoplasmic antibody associated vasculitis
- 第三军医大学学报 2019年41卷第15期页码：1497-1500
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201902006
  中图分类号：
- 收稿：2019-02-02，
  
  纸质出版：2019-08-15
- 稿件说明：
移动端阅览
秦陈浩, 顾爱萍, 展富琴, 等. 血清IgG及IgG4检测在ANCA相关性血管炎中的诊断价值[J]. 第三军医大学学报, 2019,41(15):1497-1500.

Chenhao QIN, Aiping GU, Fuqin ZHAN, et al. Diagnostic value of serum IgG and IgG4 in antineutrophil cytoplasmic antibody associated vasculitis[J]. Journal of Third Military Medical University, 2019, 41(15): 1497-1500.
秦陈浩, 顾爱萍, 展富琴, 等. 血清IgG及IgG4检测在ANCA相关性血管炎中的诊断价值[J]. 第三军医大学学报, 2019,41(15):1497-1500. DOI： 10.16016/j.1000-5404.201902006.

Chenhao QIN, Aiping GU, Fuqin ZHAN, et al. Diagnostic value of serum IgG and IgG4 in antineutrophil cytoplasmic antibody associated vasculitis[J]. Journal of Third Military Medical University, 2019, 41(15): 1497-1500. DOI： 10.16016/j.1000-5404.201902006.

摘要

Abstract

Objective

To investigate the expression of serum IgG and IgG4 in the patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)

and explore the diagnostic value of IgG4 in AAV patients.

Methods

A total of 48 patients with AAV admitted in our hospital from July 2016 to June 2018 were recruited as patient group

and 25 healthy persons during the same period were subjected as control group. Their serum samples were collected for concentration of IgG4 by ELISA

that of IgG by immunoturbidimetric assay

and those of an

ti-MPO and anti-PR3 antibodies by ship type ELISA. Student's

test was used to make data comparison between the 2 groups

one-way ANOVA was employed for comparison among the multiple groups

and LSD-

test was applied for intragroup comparison. Pearson correlation analysis was used to analyze the correlation between the 2 groups

and

0.05 was considered statistically.

Results

The serum IgG4 concentration was 1.17±0.58 g/L

and the percentage of IgG4 to IgG was (10.12±6.64)% in the AAV patients

which were significantly higher than those of healthy individuals (

0.01). So were the concentrations in the MPO-ANCA-associated and PR3-ANCA-associated AAV patients (

0.01). But there was no difference in the expression of IgG4 between the 2 subtypes (

0.05)

and there was no significant correlation between ANCA concentration and IgG4 concentration (

0.05).

Conclusion

IgG4 concentration and IgG4/IgG percentage are significantly increased in the patients with AAV or its subtypes. But there is no significant correlation with the types and ANCA concentration. Detection of IgG4 combined with ANCA is helpful in the diagnosis of AAV.

关键词

Keywords

references

JENNETTE J C FALK R J BACON P A 2012 revised international chapel hill consensus conference nomenclature of vasculitides Arthritis Rheum 2013 65 1 1 11 10.1002/art.37715 JENNETTE J C, FALK R J, BACON P A, et al . 2012 revised international chapel hill consensus conference nomenclature of vasculitides[J ] . Arthritis Rheum, 2013, 65(1): 1-11. DOI:10.1002/art.37715.

UMEHARA H OKAZAKI K MASAKI Y Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 Mod Rheumatol 2012 22 1 21 30 10.1007/s10165-011-0571-z UMEHARA H, OKAZAKI K, MASAKI Y, et al . Co mprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011[J ] . Mod Rheumatol, 2012, 22(1): 21-30. DOI:10.1007/s10165-011-0571-z.

高辉张萍李贵森 ANCA相关性肾炎合并IgG4相关性疾病一例中华肾脏病杂志 2014 12 953 954 10.3760/cma.j.issn.1001-7097.2014.12.014 高辉, 张萍, 李贵森, 等. ANCA相关性肾炎合并IgG4相关性疾病一例[J].中华肾脏病杂志, 2014(12): 953-954. DOI:10.3760/cma.j.issn.1001-7097.2014.12.014.

GAO H ZHANG P LI G S A case report of ANCA-associated nephritis with IgG4-related diseases Chin J Nephrol 2014 12 953 954 10.3760/cma.j.issn.1001-7097.2014.12.014 GAO H, ZHANG P, LI G S, et al . A case report of ANCA-associated nephritis with IgG4-related diseases[J ] . Chin J Nephrol, 2014(12): 953-954. DOI:10.3760/cma.j.issn.1001-7097.2014.12.014.

IGUCHI A WADA Y KOBAYASHI D A case of MPO- and PR3-ANCA-positive hypertrophic cranial pachymeningitis with elevated serum IgG4 Mod Rheumatol 2013 23 1 151 155 10.1007/s10165-012-0613-1 IGUCHI A, WADA Y, KOBAYASHI D, et al . A case of MPO- and PR3-ANCA-positive hypertrophic cranial pachymeningitis with elevated serum IgG4[J ] . Mod Rheumatol, 2013, 23(1): 151-155. DOI:10.1007/s10165-012-0613-1.

JENNETTE J C Overview of the 2012 revised international chapel hill consensus conference nomenclature of vasculitides Clin Exp Nephrol 2013 17 5 603 606 10.1007/s10157-013-0869-6 JENNETTE J C. Overview of the 2012 revised international chapel hill consensus conference nomenclature of vasculitides[J]. Clin Exp Nephrol, 2013, 17(5): 603-606. DOI:10.1007/s10157-013-0869-6.

CORNEC D CORNEC-LE GALL E FERVENZA F C ANCA-associated vasculitis-clinical utility of using ANCA specificity to classify patients Nat Rev Rheumatol 2016 12 10 570 579 10.1038/nrrheum.2016.123 CORNEC D, CORNEC-LE GALL E, FERVENZA F C, et al . ANCA-associated vasculitis-clinical utility of using ANCA specificity to classify patients[J ] . Nat Rev Rheumatol, 2016, 12(10): 570-579. DOI:10.1038/nrrheum.2016.123.

DANLOS F X ROSSI G M BLOCKMANS D Antineutrophil cytoplasmic antibody-associated vasculitides and IgG4-related disease: A new overlap syndrome Autoimmun Rev 2017 16 10 1036 1043 10.1016/j.autrev.2017.07.020 DANLOS F X, ROSSI G M, BLOCKMANS D, et al . Antineutrophil cytoplasmic antibody-associated vasculitides and IgG4-related disease: A new overlap syndrome[J ] . Autoimmun Rev, 2017, 16(10): 1036-1043. DOI:10.1016/j.autrev.2017.07.020.

LI Z Y MA T T CHEN M The prevalence and management of anti-neutrophil cytoplasmic antibody-associated vasculitis in China Kidney Dis (Basel) 2016 1 4 216 223 10.1159/000441912 LI Z Y, MA T T, CHEN M, et al . The prevalence and management of anti-neutrophil cytoplasmic antibody-associated vasculitis in China[J ] . Kidney Dis (Basel), 2016, 1(4): 216-223. DOI:10.1159/000441912.

SAKAIRI T OKABE S HIROMURA K A case of ANCA-negative renal small-vessel vasculitis with tubulointerstitial infiltration of IgG4-positive plasma cells Mod Rheumatol 2016 26 5 780 783 10.3109/14397595.2014.915510 SAKAIRI T, OKABE S, HIROMURA K, et al . A case of ANCA-negative renal small-vessel vasculitis with tubulointerstitial infiltration of IgG4-positive plasma cells[J ] . Mod Rheumatol, 2016, 26(5): 780-783. DOI:10.3109/14397595.2014.915510.

于峰赵明辉章友康原发性小血管炎中ANCA IgG亚型的分布及临床意义中华微生物学和免疫学杂志 2003 23 9 747 748 10.3760/j:issn:0254-5101.2003.09.028 于峰, 赵明辉, 章友康.原发性小血管炎中ANCA IgG亚型的分布及临床意义[J].中华微生物学和免疫学杂志, 2003, 23(9): 747-748. DOI:10.3760/j:issn:0254-5101.2003.09.028.

YU F ZHAO M H ZHANG Y K Distribution and clinical significance of ANCA IgG subtypes in primary vasculitis Chin J Microbiol Immunol 2003 23 9 747 748 10.3760/j:issn:0254-5101.2003.09.028 YU F, ZHAO M H, ZHANG Y K. Distribution and clinical significance of ANCA IgG subtypes in primary vasculitis[J]. Chin J Microbiol Immunol, 2003, 23(9): 747-748. DOI:10.3760/j:issn:0254-5101.2003.09.028.

KANARI H KAGAMI S KASHIWAKUMA D Role of Th2 cells in IgG4-related lacrimal gland enlargement Int Arch Allergy Immunol 2010 152 Suppl 1 47 53 10.1159/000312125 KANARI H, KAGAMI S, KASHIWAKUMA D, et al . Role of Th2 cells in IgG4-related lacrimal gland enlargement[J ] . Int Arch Allergy Immunol, 2010, 152(Suppl 1): 47-53. DOI:10.1159/000312125.

SUZUKI K TAMARU J OKUYAMA A IgG4-positive multi-organ lymphoproliferative syndrome manifesting as chronic symmetrical sclerosing dacryo-sialadenitis with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation Rheumatology (Oxford) 2010 49 9 1789 1791 10.1093/rheumatology/keq113 SUZUKI K, TAMARU J, OKUYAMA A, et al . IgG4-positive multi-organ lymphoproliferative syndrome manifesting as chronic symmetrical sclerosing dacryo-sialadenitis with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation[J ] . Rheumatology (Oxford), 2010, 49(9): 1789-1791. DOI:10.1093/rheumatology/keq113.

TIPPING P G KITCHING A R Glomerulonephritis, Th1 and Th2: what's new? Clin Exp Immunol 2005 142 2 207 215 10.1111/j.1365-2249.2005.02842.x TIPPING P G, KITCHING A R. Glomerulonephritis, Th1 and Th2: what's new?[J]. Clin Exp Immunol, 2005, 142(2): 207-215. DOI:10.1111/j.1365-2249.2005.02842.x.

SPIEGELBERG H L Fc receptors for IgE and interleukin-4 induced IgE and IgG4 secretion J Invest Dermatol 1990 94 6 s49 s52 10.1111/1523-1747.ep12875051 SPIEGELBERG H L. Fc receptors for IgE and interleukin-4 induced IgE and IgG4 secretion[J]. J Invest Dermatol, 1990, 94(6): s49-s52. DOI:10.1111/1523-1747.ep12875051.

KUROKI A IYODA M SHIBATA T Th2 cytokines increase and stimulate B cells to produce IgG4 in idiopathic membranous nephropathy Kidney Int 2005 68 1 302 310 10.1111/j.1523-1755.2005.00415.x KUROKI A, IYODA M, SHIBATA T, et al . Th2 cytokines increase and stimulate B cells to produce IgG4 in idiopathic membranous nephropathy[J ] . Kidney Int, 2005, 68(1): 302-310. DOI:10.1111/j.1523-1755.2005.00415.x.

CARBONE G WILSON A DIEHL S A Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis Int J Biol Sci 2013 9 3 279 288 10.7150/ijbs.5996 CARBONE G, WILSON A, DIEHL S A, et al . Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis[J ] . Int J Biol Sci, 2013, 9(3): 279-288. DOI:10.7150/ijbs.5996.

ZAIDAN M CERVERA-PIEROT P DE SEIGNEUX S Evidence of follicular T-cell implication in a case of IgG4- related systemic disease with interstitial nephritis Nephrol Dial Transplant 2011 26 6 2047 2050 10.1093/ndt/gfr097 ZAIDAN M, CERVERA-PIEROT P, DE SEIGNEUX S, et al . Evidence of follicular T-cell implication in a case of IgG4- related systemic disease with interstitial nephritis[J ] . Nephrol Dial Transplant, 2011, 26(6): 2047-2050. DOI:10.1093/ndt/gfr097.

TANGYE S G LIU Y J AVERSA G Identification of functional human splenic memory B cells by expression of CD148 and CD27 J Exp Med 1998 188 9 1691 1703 10.1084/jem.188.9.1691 TANGYE S G, LIU Y J, AVERSA G, et al . Identification of functional human splenic memory B cells by expression of CD148 and CD27[J ] . J Exp Med, 1998, 188(9): 1691-1703.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

暂无数据