外周血中性粒细胞与淋巴细胞比率对NSCLC患者放疗效果的预测价值

孔锐; 李奉; 郑林鹏; 孙建国

doi:10.16016/j.1000-5404.201812155

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外周血中性粒细胞与淋巴细胞比率对NSCLC患者放疗效果的预测价值

临床医学 | 更新时间：2026-01-09

- 外周血中性粒细胞与淋巴细胞比率对NSCLC患者放疗效果的预测价值
- Predictive value of peripheral blood neutrophil to lymphocyte ratio in radiotherapeutic efficacy for NSCLC patients
- 第三军医大学学报 2019年41卷第13期页码：1261-1266
- 作者机构：
  
  400037 重庆，陆军军医大学(第三军医大学)第二附属医院全军肿瘤研究所
- 作者简介：
  
  [孙建国，E-mail: sunjg09@aliyun.comSUN Jianguo, E-mail:sunjg09@aliyun.com
- 基金信息：
  
  国家自然科学基金面上项目(81773245);国家自然科学基金青年科学基金(81602688);2018年度陆军军医大学临床医学科研人才培养计划(2018XLC1010)
- DOI：10.16016/j.1000-5404.201812155
  中图分类号： R730.43;R730.55;R734.2
- 收稿：2018-12-19，
  
  修回：2019-03-10，
  
  纸质出版：2019-07-15
- 稿件说明：
移动端阅览
孔锐, 李奉, 郑林鹏, 等. 外周血中性粒细胞与淋巴细胞比率对NSCLC患者放疗效果的预测价值[J]. 第三军医大学学报, 2019,41(13):1261-1266.

Rui KONG, Feng LI, Linpeng ZHENG, et al. Predictive value of peripheral blood neutrophil to lymphocyte ratio in radiotherapeutic efficacy for NSCLC patients[J]. Journal of Third Military Medical University, 2019, 41(13): 1261-1266.
孔锐, 李奉, 郑林鹏, 等. 外周血中性粒细胞与淋巴细胞比率对NSCLC患者放疗效果的预测价值[J]. 第三军医大学学报, 2019,41(13):1261-1266. DOI： 10.16016/j.1000-5404.201812155.

Rui KONG, Feng LI, Linpeng ZHENG, et al. Predictive value of peripheral blood neutrophil to lymphocyte ratio in radiotherapeutic efficacy for NSCLC patients[J]. Journal of Third Military Medical University, 2019, 41(13): 1261-1266. DOI： 10.16016/j.1000-5404.201812155.

摘要

目的

探讨放疗前后外周血中性粒细胞与淋巴细胞比率(neutrophil to lymphocyte ratio，NLR)及其变化(ΔNLR)对晚期非小细胞肺癌(non-small cell lung cancer，NSCLC)患者放疗效果的预测价值。

方法

回顾性分析2011年3月至2016年5月本院行单纯放疗有完整随访资料的70例晚期NSCLC患者的临床资料，近期疗效分放疗敏感(PR+CR)组和非敏感(SD+PD)组，远期疗效以中位PFS为临界值分两组，分别检测各组放疗前后的血常规。以中位NLR为临界值分为高低两组，以放疗后NLR升高或降低分组，分别对比各组近期疗效的差别。

结果

放疗前NLR及其他血细胞指标与放疗敏感性、无进展生存期(progression-free survival，PFS)无相关性(

0.05)。放疗后NLR、ΔNLR与近期疗效呈负相关(

0.05)，而与PFS无明显相关；放疗后NLR中位值为4.93，当NLR＜4.93时，客观缓解率(ORR)为69%，NLR≥4.93时，ORR为37%；与放疗前比较，放疗后NLR降低(ΔNLR＜0)组ORR为71%，而放疗后NLR升高(ΔNLR≥0)组ORR为45%。放疗后PLR、MLR及ΔPLR、ΔMLR也与近期疗效呈负相关(

0.05)，且放疗后PLR、MLR与NLR存在一致性，ΔPLR、ΔMLR与ΔNLR存在一致性(

＞0.5，

0.001)。

结论

放疗后的NLR、ΔNLR可作为与放疗近期疗效相关的预测指标。

Abstract

Objective

To investigate the predictive value of neutrophil to lymphocyte ratio (NLR) in the peripheral blood and its changes (ΔNLR) after radiotherapy in advanced non-small cell lung cancer (NSCLC) patients.

Methods

The clinical data of 70 patients with advanced NSCLC who received simple radiotherapy in our hospital from March 2011 to June 2016 with complete follow-up data were retrospectively analyzed. The patients were divided into 2 groups based on the short-term efficacy: the radiotherapy sensitivity (PR+CR) group and non-sensitivity (SD+PD) group. They were also divided into 2 groups based on the long-term efficacy with median progression-free survival (PFS) as the critical value. Blood routine test was carried out before and after radiotherapy

and the results was compared between the 2 groups. Then with NLR as the critical value

the patients were divided into 2 groups. Differences in short-term efficacy were compared between those with increased NLR and those with decreased NLR.

Results

Before radiotherapy

NLR and other blood cell parameters had no correlation with radiosensitivity or PFS (

0.05). After radiotherapy

NLR and ΔNLR were negatively correlated with short-term efficacy (

0.05)

but was not correlated with PFS. After radiotherapy

NLR median value was 4.93

and objective response rate (ORR) was 69% when NLR

4.93; and was 37% when ≥4.93. In the group with decreased NLR (ΔNLR

0) after radiotherapy

ORR was 71%; in the group with increased NLR (ΔNLR≥0) after radiotherapy

ORR was 45%. Platelet to lymphocyte ratio (PLR)

monocytes to lymphocyte ratio (MLR)

ΔPLR and ΔMLR were also negatively correlated with short-term efficacy after radiotherapy (

0.05)

and PLR

MLR and NLR were consistent

while ΔPLR

ΔMLR and ΔNLR were also consistent after radiotherapy (

0.5

0.001).

Conclusion

After radiotherapy both NLR and ΔNLR can be used as predictive indicators for the short-term efficacy of radiotherapy in NSCLC patients.

关键词

Keywords

references

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