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全身奥曲肽显像在儿童神经母细胞瘤诊断及分期中的应用价值
Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in children
- 第三军医大学学报 2019年41卷第13期 页码：1275-1280
- 作者机构：
400010 重庆，重庆医科大学附属第二医院核医学科
- 作者简介：
[袁耿彪，E-mail：yuan_gb@126.comYUAN Gengbiao, E-mail: yuan_gb@126.com
- 基金信息：
DOI：10.16016/j.1000-5404.201812134
中图分类号： R739.4;R814.42;R981收稿：2018-12-16，
修回：2019-01-07，
纸质出版：2019-07-15
- 稿件说明：
移动端阅览
熊亚岚, 袁耿彪, 郑晨曦, 等. 全身奥曲肽显像在儿童神经母细胞瘤诊断及分期中的应用价值[J]. 第三军医大学学报, 2019,41(13):1275-1280.
Yalan XIONG, Gengbiao YUAN, Chengxi ZHENG, et al. Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in children[J]. Journal of Third Military Medical University, 2019, 41(13): 1275-1280.
熊亚岚, 袁耿彪, 郑晨曦, 等. 全身奥曲肽显像在儿童神经母细胞瘤诊断及分期中的应用价值[J]. 第三军医大学学报, 2019,41(13):1275-1280. DOI： 10.16016/j.1000-5404.201812134.
Yalan XIONG, Gengbiao YUAN, Chengxi ZHENG, et al. Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in children[J]. Journal of Third Military Medical University, 2019, 41(13): 1275-1280. DOI： 10.16016/j.1000-5404.201812134.
摘要
目的
2
探讨全身奥曲肽显像在儿童神经母细胞瘤(neuroblastoma，NB)诊断及分期中的应用价值。
方法
2
对本院2016年3月至2018年3月接诊的32例临床疑似NB并至少接受了一项传统影像学检查[超声、计算机断层扫描(computed tomography
CT)及核磁共振成像(magnetic resonance imaging
MRI)
]
的患儿进行全身
99m
Tc-奥曲肽显像(
99m
Technetium-Hydrazinonicotinyl- Tyr 3-Octreotide，
99m
Tc-HTOC)检查，结果由两位主治或主任医师进行判定，参照标准为组织病理学、传统影像学及临床随访结果相结合。
结果
2
99m
Tc-HTOC显像诊断灵敏度96.7%(29/30例)，特异度50%(1/2例)，阳性预测值96.7%(29/30例)，阴性预测值50%(1/2例)，诊断符合率达93.8%(30/32例)。有3例(10%)患儿行
99m
Tc-HTOC显像后改变了初始分期，其中1例患儿从ⅡA期上升到Ⅳ期，其余2例患儿从Ⅲ期上升到Ⅳ期。
结论
2
99m
Tc-HTOC显像提高了NB初始分期的准确性，可应用于儿童NB的诊断及分期。
Abstract
Objective
2
To investigate the application value of
99m
technetium-hydrazinonicotinyl-tyr 3-octreotide (
99m
Tc-HTOC) imaging in the diagnosis and staging of neuroblastoma (NB) in children.
Methods
2
99m
Tc-HTOC scintigraphy was performed on 32 NB suspected children who received at least 1 conventional imaging examination [ultrasound examination
computed tomography (CT)
or magnetic resonance imaging (MRI)
]
from March 2016 to March 2018 in our hospital. Images were evaluated by 2 experienced nuclear medicine physicians or archiaters. The combination of the results of pathological examination
traditional imaging examination and clinical follow-up wer
e reference standards.
Results
2
The sensitivity of
99m
Tc-HTOC imaging was 96.7% (29/30)
specificity was 50% (1/2)
positive predictive value was 96.7% (29/30)
negative predictive value was 50% (1/2) and diagnostic coincidence rate was 93.8% (30/32). The initial stage was changed in 3 patients (10%) after the
99m
Tc-HTOC imaging. One of the patients was increased from stage ⅡA to stage Ⅳ
and the remaining 2 patients were increased from stage Ⅲ to stage Ⅳ.
Conclusion
2
99m
Tc-HTOC imaging improves the accuracy of NB initial staging
and can be used in the diagnosis and staging of NB in children.
关键词
Keywords
references
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