
浏览全部资源
扫码关注微信
400016 重庆,重庆医科大学附属第一医院神经内科
[ 秦新月,E-mail:qinxinyue@yahoo.com QIN Xinyue, E-mail: qinxinyue@yahoo.com
收稿:2018-09-14,
修回:2018-10-09,
纸质出版:2019-01-30
移动端阅览
袁明皓, 张文玉, 邹宁, 等. 急性脑梗死患者并发肺部感染的危险因素分析[J]. 第三军医大学学报, 2019,41(2):153-157.
Minghao YUAN, Wenyu ZHANG, Ning ZOU, et al. Risk factors for pulmonary infection in patients with acute cerebral infarction[J]. Journal of Third Military Medical University, 2019, 41(2): 153-157.
袁明皓, 张文玉, 邹宁, 等. 急性脑梗死患者并发肺部感染的危险因素分析[J]. 第三军医大学学报, 2019,41(2):153-157. DOI: 10.16016/j.1000-5404.201809110.
Minghao YUAN, Wenyu ZHANG, Ning ZOU, et al. Risk factors for pulmonary infection in patients with acute cerebral infarction[J]. Journal of Third Military Medical University, 2019, 41(2): 153-157. DOI: 10.16016/j.1000-5404.201809110.
目的
2
研究急性脑梗死患者并发肺部感染的危险因素。
方法
2
收集2017年4-12月重庆医科大学附属第一医院神经内科住院的急性脑梗死患者417例,对可能并发肺部感染的相关因素进行汇总,比较肺部感染组和非肺部感染组临床资料的差异,并进行多因素Logistic回归分析。
结果
2
肺部感染组(
n
=92)与非肺部感染组(
n
=325)比较,年龄、性别、住院天数、吸烟、既往肺部疾病史、冠心病、高血脂、吞咽困难、入院时意识障碍、完全卧床、侵入性操作、入院时美国国立卫生院神经功能缺损评分(National Institutes of Health stroke scale score,NIHSS)、入院时改良RANKIN量表评分(modified rankin scale score,MRS)差异均具有统计学意义(
P
<
0.05)。多因素Logistic回归分析示:入院时NIHSS评分
>
14分、年龄
>
65岁、侵入性操作、完全卧床是急性脑梗死患者并发肺部感染的危险因素(
OR
=5.410、2.714、21.823、3.013,95%
CI
:1.835~15.953、1.257~5.587、10.265~46.393、1.365~6.651,
P
均
<
0.05)。
结论
2
入院时NIHSS评分、年龄、侵入性操作、完全卧床可作为防治急性脑梗死后并发肺部感染的参考指标。
Objective
2
To explore the risk factors of pulmonary infection in patients with acute cerebral infarction.
Methods
2
We retrospectively reviewed the clinical data of 417 patients admitted for acute cerebral infarction in our hospital between April and December
2017. We compared the data between the patients with and without pulmonary infection
and analyzed the risk factors for pulmonary infection following acute cerebral infarction using multiple logistic regression analysis.
Results
2
There were significant differences in age
gender
length of hospital stay
smoking
history of previous lung disease
coronary heart disease
hyperlipidemia
dysphagia
consciousness disturbance at admission
complete bed rest
invasive operation
National Institutes of Health Stroke Scale (NIHSS) score and Modified Rankin Scale (MRS) score at admission between the pulmonary infection group(
n
=92) and the non-pulmonary infection group(
n
=325) (
P
<
0.05). Multiple logistic regression analysis suggested that NIHSS score
>
14 at admission
age
>
65 years
invasive operation
and complete bed rest were risk factors for pulmonary infection in patients with acute cerebral infarction(
OR
=5.410
2.714
21.823
3.013
95%
CI
:1.835~15.953
1.257~5.587
10.265~46.393
1.365~6.651
all
P
<
0.05).
Conclusion
2
NIHSS score at admission
age
invasive operation and complete bed rest may be regarded as reference indexes in the prevention and treatment of pulmonary infection after acute cerebral infarction.
LOZANO R, NA GHAVI M, FOREMAN K, et al . Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010[J ] . Lancet, 2012, 380(9859): 2095-2128. DOI: 10.1016/S0140-6736(12)61728-0.
WINKLEWSKI P J, RADKOWSKI M, DEMKOW U. Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke[J]. J Neuroinflamm, 2014, 11: 213. DOI: 10.1186/s12974-014-0213-4.
SHI K, WOOD K, SHI F D, et al . Stroke-induced immunosuppression and poststroke infection[J ] . Stroke Vasc Neurol, 2018, 3(1): 34-41. DOI: 10.1136/svn-2017-000123.
Liu L, Xiong X Y, Zhang Q, et al . The efficacy of prophylactic antibiotics on post-stroke infections: an updated systematic review and meta-analysis[J ] . Sci Rep, 2016, 6: 36656. DOI: 10.1038/srep36656.
ZHENG F, SPRECKELSEN N V, ZHANG X, et al . Should preventive antibiotics be used in patients with acute stroke? A systematic review and meta-analysis of randomized controlled trials[J ] . PLoS ONE, 2017, 12(10): e0186607. DOI: 10.1371/journal.pone.0186607.
刘鸣, 蒲传强.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志, 2015, 48(4): 246-257. DOI: 10.3760/cma.j.issn.1006-7876.2015.04.002.
LIU M, PU C Q. Guidelines for the diagnosis and treatment of acute ischemic stroke in China in 2014[J]. Chin J Neurol, 2015, 48(4): 246-257. DOI: 10.3760/cma.j.issn.1006-7876.2015.04.002.
陆茸, 贡换龙, 马莹, 等.神经外科患者合并肺部感染临床特征分析[J].中国医药导刊, 2014(3): 412-413, 415.
LU R, GONG H L, MA Y, et al . Related factors and prevention of lower respiratory tract infection in traumatic brain injury[J ] . Chin J Med Guide, 2014(3): 412-413, 415.
张道松, 秦天成.老年急性脑梗死伴发肺部感染36例危险因素分析[J].中国社区医师, 2017, 33(20): 78-79. DOI: 10.3969/j.issn.1007-614x.2017.20.47.
ZHANG D S, QIN T C. Risk factors of pulmonary infection in elderly patients with acute cerebral infarction:an analysis of 36 cases[J]. Chin Community Doct, 2017, 33(20): 78-79. DOI: 10.3969/j.issn.1007-614x.2017.20.47.
张丽仙.急性脑梗死患者并发肺部感染的影响因素分析[J].内蒙古医学杂志, 2015, 47(11): 1366-1367. DOI: 10.16096/J.cnki.nmgyxzz.2015.47.11.037.
ZHANG L X. Analysis of the influencing factors of pulmonary infection in patients with acute cerebral infarction[J]. Inner Mongofia Med J, 2015, 47(11): 1366-1367. DOI: 10.16096/J.cnki.nmgyxzz.2015.47.11.037.
门中华.急性脑卒中合并肺部感染相关因素及对预后的影响[J].中华医院感染学杂志, 2012, 22(10): 2053-2055.
MEN Z H. Risk factors for pulmonary infections in patients with acute cerebral apoplexy and influence on prognosis[J]. Chin J Nosocomiol, 2012, 22(10): 2053-2055.
苏灵芝.脑卒中患者并发肺部感染相关因素分析[J].包头医学院学报, 2009, 25(5): 62-63. DOI: 10.3969/j.issn.1006-740X.2009.05.028.
SU L Z. Analysis of related factors of pulmonary infection in stroke patients[J]. J Baotou Med Coll, 2009, 25(5): 62-63. DOI: 10.3969/j.issn.1006-740X.2009.05.028.
许丽娜, 贾龙斌, 郭嘉英, 等.急性脑血管疾病并发肺部感染患者的临床特点研究[J].中华医院感染学杂志, 2017(19): 4405-4408. DOI: 10.11816/cn.ni.2017-170553.
XU L N, JIA L B, GUO J Y, et al . Clinical characteristics of acute cerebrovascular disease complicated with pulmonary infections[J ] . Chin J Nosocomiol, 2017(19): 4405-4408. DOI: 10.11816/cn.ni.2017-170553.
徐春华, 姜宇.急性脑血管病并发肺部感染的防治策略[J].中国医药指南, 2011, 9(32): 109-110. DOI: 10.3969/j.issn.1671-8194.2011.32.082.
XU C H, JIANG Y. Prevention and treatment of acute cerebrovascular disease complicated with pulmonary infection[J]. Guide Chin Med, 2011, 09(32): 109-110. DOI: 10.3969/j.issn.1671-8194.2011.32.082.
余永程, 郑江环, 杨华荣, 等. NICU患者并发肺部感染的危险因素分析[J].中华医院感染学杂志, 2013, 23(7): 1538-1539, 1552.
YU Y C, ZHENG J H, YANG H R, et al . Risk factors of pulmonary infections in NICU patients[J ] . Chin J Nosocomiol, 2013, 23(7): 1538-1539, 1552.
冯鑫.老年急性脑梗死合并肺部感染患者危险因素和预后相关研究[J].中国保健营养, 2017, 27(5): 282-283.
FENG X. Risk factors and prognosis in elderly patients with acute cerebral infarction complicated with pulmonary infection[J]. China Health Nutr, 2017, 27(5): 282-283.
ZHANG X, YU S, WEI L, et al . The A2DS2 score as a predictor of pneumonia and in-hospital death after acute ischemic stroke in chinese populations[J ] . PLoS ONE, 2016, 11(3): e0150298. DOI: 10.1371/journal.pone.0150298.
ASHOUR W, AL-ANWAR A D, KAMEL A E, et al . Predictors of early infection in cerebral ischemic stroke[J ] . J Med Life, 2016, 9(2): 163-169.
ARAI N, NAKAMIZO T, IHARA H, et al . Histamine H2-blocker and proton pump inhibitor use and the ri sk of pneumonia in acute stroke: A retrospective analysis on susceptible patients[J ] . PLoS ONE, 2017, 12(1): e0169300. DOI: 10.1371/journal.pone.0169300.
HERZIG S J, DOUGHTY C, LAHOTI S, et al . Acid-suppressive medication use in acute stroke and hospital-acquired pneumonia[J ] . Ann Neurol, 2014, 76(5): 712-718. DOI:10.1002/ana.24262.
HO S W, HSIEH M J, YANG S F, et al . Risk of stroke-associated pneumonia with acid-suppressive drugs: A population-based cohort study[J ] . Medicine (Baltimore), 2015, 94(29): e1227. DOI:10.1097/MD.000000000 0001227.
0
浏览量
0
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621