超声清创联合负压吸引对痛风石破溃创面疗效的随机对照研究

包可久; 刘颖; 周丽娜; 陈兵

doi:10.16016/j.1000-5404.201809056

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超声清创联合负压吸引对痛风石破溃创面疗效的随机对照研究

临床医学 | 更新时间：2026-01-09

- 超声清创联合负压吸引对痛风石破溃创面疗效的随机对照研究
- Efficacy of vacuum sealing drainage combined with ultrasonic debridement surgical system on gouty tophus ulcer: a randomized controlled trial
- 第三军医大学学报 2019年41卷第5期页码：473-477
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)第一附属医院内分泌科
- 作者简介：
  
  [周丽娜: E-mail:407283721@qq.com ZHOU Lina, E-mail:407283721@qq.com
  [陈兵: E-mail:286628359@qq.com CHEN Bing, E-mail:286628359@qq.com
- 基金信息：
  
  重庆市技术创新与应用示范社会民生类一般项目(CSTC2018jscx-msybX0117)
- DOI：10.16016/j.1000-5404.201809056
  中图分类号： R454;R589.7;R632.1
- 收稿：2018-09-05，
  
  修回：2018-11-12，
  
  纸质出版：2019-03-15
- 稿件说明：
移动端阅览
包可久, 刘颖, 周丽娜, 等. 超声清创联合负压吸引对痛风石破溃创面疗效的随机对照研究[J]. 第三军医大学学报, 2019,41(5):473-477.

Kejiu BAO, Ying LIU, Lina ZHOU, et al. Efficacy of vacuum sealing drainage combined with ultrasonic debridement surgical system on gouty tophus ulcer: a randomized controlled trial[J]. Journal of Third Military Medical University, 2019, 41(5): 473-477.
包可久, 刘颖, 周丽娜, 等. 超声清创联合负压吸引对痛风石破溃创面疗效的随机对照研究[J]. 第三军医大学学报, 2019,41(5):473-477. DOI： 10.16016/j.1000-5404.201809056.

Kejiu BAO, Ying LIU, Lina ZHOU, et al. Efficacy of vacuum sealing drainage combined with ultrasonic debridement surgical system on gouty tophus ulcer: a randomized controlled trial[J]. Journal of Third Military Medical University, 2019, 41(5): 473-477. DOI： 10.16016/j.1000-5404.201809056.

摘要

目的

探讨痛风石破溃患者使用超声清创联合负压吸引治疗创面的临床疗效及安全性。

方法

选择2014年9月至2017年12月我科住院的痛风合并痛风石破溃的患者96例，随机分为2组(

=48):试验组[年龄(51.3±7.6)岁，病程(6.8±1.1)年，BMI(25.7±1.2)，创面面积(1.62±0.23)cm

]

采取超声清创联合负压吸引术治疗，对照组[年龄(52.4±6.9)岁，病程(6.5±1.3)年，BMI(26.1±1.4)，创面面积(1.65±0.21)cm

]

采取常规手工清创换药治疗。比较2组患者的创面愈合程度、治愈率、显效率，以及治疗前后患处视觉模拟疼痛评分(visual analogue scale，VAS)，住院费用和不良反应发生情况。

结果

治疗后试验组:痛风石破溃创面疗效优于对照组(

0.05)；第5天的显效率和第10、15、20、25、30天的治愈率显著高于对照组，患处VAS评分显著低于对照组，差异均有统计学意义(

0.05)；2组间住院费用差异无统计学意义(

0.05)；试验组超声清创过程中出现2例(4.2%)患处剧烈疼痛，对照组3例(6.3%)出现延迟愈合，两组不良反应发生率差异无统计学意义(

0.05)。

结论

超声清创联合负压吸引能够缩短痛风石破溃创面愈合时间、提高创面愈合质量、不增加不良反应发生率及总住院费用。

Abstract

Objective

To investigate the clinical effects and safety of vacuum sealing drainage (VSD) combined with ultrasonic debridement surgical system (UDSS) on the patients with gouty tophus ulceration.

Methods

Totally 96 patients suffering from gout and gou

ty tophus ulceration admitted in our department from September 2014 to December 2017 were recruited

and then randomly divided into 2 groups (

=48 for each group). The patients from the experiment group (51.3±7.6 years old

disease course of 6.8±1.1 years

BMI 25.7±1.2

wound area 1.62±0.23 cm

) were treated with UDSS combined VSD

and those from the control group (52.4±6.9 years old

disease course of 6.5±1.3 years

BMI 26.1±1.4

wound area 1.65±0.21 cm

) were treated with conventional surgical debridement. Wound healing

cure rate

effective rate

visual analogue scale (VAS) score before and after treatment

cost of hospitalization

and incidences of adverse reactions were observed and compared between the 2 groups.

Results

Compared with the control group

the experimental group obtained better wound healing (

0.05)

higher effective rate on day 5

and higher cure rates on days 10

25 and 30

but lower VAS score after the treatment (

0.05). There were no differences in the costs of hospitalization or incidences of adverse reactions between the 2 groups (

0.05). Two cases (4.2%) from the experimental group experienced acute pain in affected area during ultrasonic debridement

and 3 cases (6.3%) had delayed healing.

Conclusion

UDSS combined with VSD can accelerate wound healing

improve healing outcome

and have no effect on the costs of hospitalization or incidences of adverse reactions.

关键词

Keywords

references

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