镍纹样蛋白与非酒精性脂肪性肝病的相关性研究

王育林; 姜友昭; 练渝; 陈兵

doi:10.16016/j.1000-5404.201808169

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镍纹样蛋白与非酒精性脂肪性肝病的相关性研究

临床医学 | 更新时间：2026-01-09

- 镍纹样蛋白与非酒精性脂肪性肝病的相关性研究
- Correlation of serum meteorin-like protein with non-alcoholic fatty liver disease: an analysis of 183 cases
- 第三军医大学学报 2018年40卷第21期页码：1996-2000
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201808169
  中图分类号：
- 收稿：2018-08-15，
  
  纸质出版：2018-11-15
- 稿件说明：
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王育林, 姜友昭, 练渝, 等. 镍纹样蛋白与非酒精性脂肪性肝病的相关性研究[J]. 第三军医大学学报, 2018,40(21):1996-2000.

Yulin WANG, Youzhao JIANG, Yu LIAN, et al. Correlation of serum meteorin-like protein with non-alcoholic fatty liver disease: an analysis of 183 cases[J]. Journal of Third Military Medical University, 2018, 40(21): 1996-2000.
王育林, 姜友昭, 练渝, 等. 镍纹样蛋白与非酒精性脂肪性肝病的相关性研究[J]. 第三军医大学学报, 2018,40(21):1996-2000. DOI： 10.16016/j.1000-5404.201808169.

Yulin WANG, Youzhao JIANG, Yu LIAN, et al. Correlation of serum meteorin-like protein with non-alcoholic fatty liver disease: an analysis of 183 cases[J]. Journal of Third Military Medical University, 2018, 40(21): 1996-2000. DOI： 10.16016/j.1000-5404.201808169.

摘要

Abstract

Objective

To explore the correlation between meteorin-like protein (Metrnl) and non-alcoholic fatty liver disease (NAFLD) and analyze the influencing factors of the disease.

Methods

A total of 183 NAFLD in- and out-patients (115 males and 68 females) who were admitted to our hospital during 2017 and 2018 were enrolled in this study. Another 210 health individuals (88 males and 122 females) taking physical examination during the same period served as control group. The general clinical data

results of laboratory biochemical examinations and serum Metrnl level were collected and measured

and the differences were compared between the 2 groups. The correlations of serum Metrnl with NAFLD and metabolic indexes were investigated by Spearman correlation analysis

and the influencing factors of the disease were analyzed by logistic regression analysis.

Results

The serum Metrnl level was significantly lower in the NAFLD group than the control group (

0.05). The serum level of Metrnl was negatively correlated with age

glutaminyl transferase (GGT) and alanine aminotransferase (ALT)

uric acid

blood glucose

insulin resistance index (HOMA-IR)

low density lipoprotein-cholestero

l (LDL-C) and triglyceride (TG)

body weight

body mass index (BMI)

and diastolic and systolic blood pressure

and was positively correlated with aspartate aminotransferase (AST) and high density lipoprotein-cholesterol (HDL-C). Logistic regression analysis found that serum Metrnl

uric acid

blood glucose

HDL-C

BMI

and diastolic and systolic blood pressures were independent influencing factors for NAFLD.

Conclusion

Decreased serum Metrnl is an independent risk factor for the incidence of NAFLD

and the protein is closely associated with the disease and metabolic disease related indexes.

关键词

Keywords

references

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