艾塞那肽对超重/肥胖2型糖尿病患者内脏脂肪及早期肾损伤的影响

乔巧; 徐静; 王建; 郑宏庭; 童强; 白倩; 袁媛

doi:10.16016/j.1000-5404.201807188

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艾塞那肽对超重/肥胖2型糖尿病患者内脏脂肪及早期肾损伤的影响

临床医学 | 更新时间：2026-01-09

- 艾塞那肽对超重/肥胖2型糖尿病患者内脏脂肪及早期肾损伤的影响
- Effect of exenatide treatment on visceral fat and early renal injury in overweight/obese T2DM patients
- 第三军医大学学报 2018年40卷第20期页码：1883-1888
- 作者机构：
  
  1.400037 重庆，陆军军医大学(第三军医大学)第二附属医院：内分泌科
  2.400037 重庆，陆军军医大学(第三军医大学)第二附属医院：营养科
- 作者简介：
  
  [徐静，E-mail: 13512380018@163.com XU Jing, E-mail: 13512380018@163.com
- 基金信息：
  
  重庆市社会民生科技创新专项项目(CTSTC2015shmszx120014);重庆市集成示范计划(CSTC2015jcsf10003);第三军医大学第二附属医院临床科研项目(2014YLC20)
- DOI：10.16016/j.1000-5404.201807188
  中图分类号： R587.1;R589.2;R977.15
- 收稿：2018-07-26，
  
  修回：2018-09-10，
  
  纸质出版：2018-10-30
- 稿件说明：
移动端阅览
乔巧, 徐静, 王建, 等. 艾塞那肽对超重/肥胖2型糖尿病患者内脏脂肪及早期肾损伤的影响[J]. 第三军医大学学报, 2018,40(20):1883-1888.

Qiao QIAO, Jing XU, Jian WANG, et al. Effect of exenatide treatment on visceral fat and early renal injury in overweight/obese T2DM patients[J]. Journal of Third Military Medical University, 2018, 40(20): 1883-1888.
乔巧, 徐静, 王建, 等. 艾塞那肽对超重/肥胖2型糖尿病患者内脏脂肪及早期肾损伤的影响[J]. 第三军医大学学报, 2018,40(20):1883-1888. DOI： 10.16016/j.1000-5404.201807188.

Qiao QIAO, Jing XU, Jian WANG, et al. Effect of exenatide treatment on visceral fat and early renal injury in overweight/obese T2DM patients[J]. Journal of Third Military Medical University, 2018, 40(20): 1883-1888. DOI： 10.16016/j.1000-5404.201807188.

摘要

目的

探讨艾塞那肽对超重/肥胖的2型糖尿病(type 2 diabetes mellitus，T

DM)患者的微量白蛋白尿(microalbuminuria，MAU)排泄及与内脏脂肪面积(visceral fat area，VFA)、体质指数(body mass index，BMI)、腰臀比(waist-to-hip ratio，WHR)的关系及影响。

方法

收集本科2015年1月至2016年6月就诊的符合标准的超重/肥胖的2型糖尿病患者76例，按简单随机化原则分成两组，在原口服降糖方案血糖控制不佳基础上，艾塞那肽组接受艾塞那肽注射液皮下注射，每日2次，对照组采用甘精胰岛素，每日1次，整个治疗共计24周。观察两组患者治疗前后MAU、VFA、BMI、WHR、空腹血糖(fasting blood glucose，FBG)、糖化血红蛋白(glycated hemoglobin，HbA1c)的变化，并进行相关分析。

结果

艾塞那肽组患者在治疗12周和24周后的MAU、VFA、BMI、WHR、FBG、HbA1c较治疗前明显下降(

0.05)，而对照组仅有BMI、FBG和HbA1c呈现明显下降(

0.05)。艾塞那肽组VFA、BMI、WHR、MAU的变化与FBG、HbA1c的变化呈显著正相关(

0.05)。

结论

艾塞那肽可显著降低超重/肥胖的2型糖尿病患者的MAU排泄、血糖和体脂水平，且MAU排泄下降同VFA、BMI、WHR、血糖的降低密切相关。

Abstract

Objective

To investigate the relationship and effect of exenatide on microalbuminuria (MAU)

visceral fat area (VFA)

body mass index (BMI)

and waist-to-hip ratio (WHR) in overweight/obese patients with type 2 diabetes mellitus (T2DM).

Methods

A total of 77 overweight/obese T2DM patients who met our criteria and admitted in our hospital from January 2015 to June 2016 were enrolled in this study. They were randomly divided into exenatide group and control group. Since their poor glycemic control by original oral hypoglycemic protocol

exenatide injection was given subcutaneously to the former group twice a day

and insulin glargine injection to the latter group

once a day for a total of 24 weeks. The changes of MAU

VFA

BMI

WHR

fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) were observed before and after treatment in the 2 groups

and the correlation analysis was made.

Results

The levels of MAU

VFA

BMI

WHR

PBG and HbA1c were significantly decreased in the exenatide group after 12 and 24 weeks' treatment (

.05). In the exenatide group

the changes of MAU

VFA

BMI and WHR were positively correlated with those of PBG and HbA1c (

0.05)

while such differences were only found in the levels of BMI

PBG and HbA1c in the control group (

0.05). In the exenatide group

the changes of MAU

VFA

BMI and WHR were positively correlated with those of PBG and HbA1c (

0.05).

Conclusions

Exenatide obviously reduces MAU

obesity and blood glucose in overweight/obese T2DM patients

and the excretion of MAU is closely associated with the decreases of VFA

WHR

BMI and blood glucose.

关键词

Keywords

references

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