267例无生育史的子宫肌瘤患者经高强度聚焦超声消融治疗术后妊娠结局分析

王玲; 胡亮; 刘畅; 尹娜; 王智彪; 陈锦云

doi:10.16016/j.1000-5404.201803109

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267例无生育史的子宫肌瘤患者经高强度聚焦超声消融治疗术后妊娠结局分析

临床医学 | 更新时间：2026-01-09

- 267例无生育史的子宫肌瘤患者经高强度聚焦超声消融治疗术后妊娠结局分析
- Analysis of pregnancy outcomes in 267 nulliparous women after high-intensity focused ultrasound ablation of uterine fibroids
- 第三军医大学学报 2018年40卷第20期页码：1865-1869
- 作者机构：
  
  1.400016 重庆, 重庆医科大学生物医学工程学院, 省部共建国家重点实验室培育基地-重庆市超声医学工程重点实验室, 重庆市生物医学工程学重点实验室，重庆市微无创医学协同创新中心
  2.400016 重庆, 重庆医科大学附属第一医院超声消融治疗中心
- 作者简介：
  
  [陈锦云，E-mail：chenjy@cqmu.edu.cn CHEN Jinyun, E-mail: chenjy@cqmu.edu.cn
- 基金信息：
  
  重庆市自然科学基金(CSTC 2016jcyjA0098);重庆市自然科学基金(CSTC 2016jcyjA0599)
- DOI：10.16016/j.1000-5404.201803109
  中图分类号： R454.3;R714.3;R737.33
- 收稿：2018-03-14，
  
  修回：2018-05-15，
  
  纸质出版：2018-10-30
- 稿件说明：
移动端阅览
王玲, 胡亮, 刘畅, 等. 267例无生育史的子宫肌瘤患者经高强度聚焦超声消融治疗术后妊娠结局分析[J]. 第三军医大学学报, 2018,40(20):1865-1869.

Ling WANG, Liang HU, Chang LIU, et al. Analysis of pregnancy outcomes in 267 nulliparous women after high-intensity focused ultrasound ablation of uterine fibroids[J]. Journal of Third Military Medical University, 2018, 40(20): 1865-1869.
王玲, 胡亮, 刘畅, 等. 267例无生育史的子宫肌瘤患者经高强度聚焦超声消融治疗术后妊娠结局分析[J]. 第三军医大学学报, 2018,40(20):1865-1869. DOI： 10.16016/j.1000-5404.201803109.

Ling WANG, Liang HU, Chang LIU, et al. Analysis of pregnancy outcomes in 267 nulliparous women after high-intensity focused ultrasound ablation of uterine fibroids[J]. Journal of Third Military Medical University, 2018, 40(20): 1865-1869. DOI： 10.16016/j.1000-5404.201803109.

摘要

目的

探讨无生育史的子宫肌瘤患者经高强度聚焦超声(high-intensity focused ultrasound

HIFU)消融治疗的妊娠情况及其相关因素。

方法

选择2010年1月至2016年12月在重庆医科大学附属第一医院接受HIFU消融治疗子宫肌瘤的无生育史的患者423例，其中有生育计划及生育条件者267例，随访其术后妊娠情况并分析相关影响因素。

结果

中位随访时间为4(1~7)年，155例于HIFU术后(14.1±12.4)个月妊娠，共妊娠157次，术后妊娠率为58.80%(157/267)

自然受孕率93.63%(147/157)。106次成功分娩新生儿109名，其中6名同卵双生儿；剖宫产率69.81%(74/106)。尚有26例仍在妊娠中。多因素分析发现年龄、术前不孕史是影响术后妊娠的主要因素(

0.05)；而肌瘤类型、肌瘤在HIFU术后的体积变化对妊娠结局无明显影响(

0.05)。

结论

无生育史的子宫肌瘤患者经高强度聚焦超声消融治疗后有较好的妊娠率，HIFU消融治疗子宫肌瘤对无生育史有生育要求的子宫肌瘤患者有应用价值；影响术后妊娠的主要因素为年龄、术前不孕史。

Abstract

Objective

To investigate the pregnancy outcomes in nulliparous women after high-intensity focused ultrasound (HIFU) ablation of uterine fibroids.

Methods

Between January

2010 and December

2016

423 nulliparous women with uterine fibroids underwent HIFU treatment at the First Affiliated Hospital of Chongqing Medical University. a total of 267 of these women who had pregnancy intention were enrolled in this study

and their pregnancy outcomes were followed up and the factors affecting the pregnancy outcomes were explored.

Results

During the follow-up (median 4 years

ranging from 1 to 7 years)

a total of 157 pregnancies were recorded in 155 women. The average time to pregnancy was 14.1±12.4 months following HIFU

with a pregnancy rate of 58.80% (157/267) and a spontaneous conception rate of 93.63% (147/157). a total of 109 live births (including 6 twins) were achieved in 106 successful deliveries

with a caesarean section rate of 69.81% (74/106). On-going pregnancies were found in 26 women. Multivariate analysis revealed that age and a history of infertility were the primary factors affecting the postoperative pregnancy after HIFU (

0.05)

while the changes in myoma volume after HIFU or the type of myoma did not significantly affect the postoperative pregnancy (

0.05).

Conclusions

Nulliparous women receiving HIFU for uterine fibroids can have a favorable postoperative pregnancy outcome

suggesting the value of HIFU in treatment of uterine fibroids in nulliparous women who have pregnancy intentions. The main factors affecting postoperative pregnancy are age and a history of preoperative infertility.

关键词

Keywords

references

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