广西部分艾滋病高流行区人类免疫缺陷病毒母婴阻断效果及及时性、依从性研究

覃寿学; 谭健坤; 施容光; 吴宏燕; 农燕丽; 程玉清; 卢炳炎

doi:10.16016/j.1000-5404.201803078

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广西部分艾滋病高流行区人类免疫缺陷病毒母婴阻断效果及及时性、依从性研究

公共卫生与预防医学 | 更新时间：2026-01-09

- 广西部分艾滋病高流行区人类免疫缺陷病毒母婴阻断效果及及时性、依从性研究
- Interventions for prevention of mother-to-child HIV transmission in regions with a high HIV/AIDS prevalence in Guangxi Zhuang Autonomous Region: success rate, timeliness and patient compliance
- 第三军医大学学报 2018年40卷第18期页码：1704-1710, 封三
- 作者机构：
  
  1.537100 广西贵港，贵港市妇幼保健院保健部
  2.537200 广西桂平，桂平市妇幼保健院妇产科
  3.537300 广西平南，平南县妇幼保健院保健部
  4.537300 广西平南，平南县人民医院感染科
- 作者简介：
  
  [ 覃寿学，E-mail: qsx1946985651@163.com QIN Shouxue, E-mail: qsx1946985651@163.com
- 基金信息：
  
  广西贵港市科学研究与技术开发计划项目(GKC1504041)
- DOI：10.16016/j.1000-5404.201803078
  中图分类号： R373.9;R725.129.1;R978.7
- 收稿：2018-03-11，
  
  修回：2018-05-02，
  
  纸质出版：2018-09-30
- 稿件说明：
移动端阅览
覃寿学, 谭健坤, 施容光, 等. 广西部分艾滋病高流行区人类免疫缺陷病毒母婴阻断效果及及时性、依从性研究[J]. 第三军医大学学报, 2018,40(18):1704-1710, 封三.

Shouxue QIN, Jiankun TAN, Rongguang SHI, et al. Interventions for prevention of mother-to-child HIV transmission in regions with a high HIV/AIDS prevalence in Guangxi Zhuang Autonomous Region: success rate, timeliness and patient compliance[J]. Journal of Third Military Medical University, 2018, 40(18): 1704-1710, 封三.
覃寿学, 谭健坤, 施容光, 等. 广西部分艾滋病高流行区人类免疫缺陷病毒母婴阻断效果及及时性、依从性研究[J]. 第三军医大学学报, 2018,40(18):1704-1710, 封三. DOI： 10.16016/j.1000-5404.201803078.

Shouxue QIN, Jiankun TAN, Rongguang SHI, et al. Interventions for prevention of mother-to-child HIV transmission in regions with a high HIV/AIDS prevalence in Guangxi Zhuang Autonomous Region: success rate, timeliness and patient compliance[J]. Journal of Third Military Medical University, 2018, 40(18): 1704-1710, 封三. DOI： 10.16016/j.1000-5404.201803078.

摘要

目的

系统评价广西部分高流行区人类免疫缺陷病毒(human immunodeficiency virus

HIV)母婴阻断效果及及时性、依从性，探讨相关影响因素。

方法

2011年1月至2017年9月，采取非概率整群抽样和随访观察研究，对广西部分艾滋病高流行区内319例调查对象进行母婴阻断干预，从传播率、及时性和依从性等方面了解HIV母婴阻断效果，采用Logistic回归模型分析接受干预及时性和依从性的相关影响因素。

结果

继续妊娠HIV感染孕产妇用药率为95.92%(306/319)；安全分娩率70.51%(225/319)，呈逐年升高趋势(

=2.03，

=0.042)，累计分娩活婴295例；儿童用药率98.31%(290/295)，人工喂养率98.64%(291/295)，早期诊断率96.20%(152/158)，18月龄抗体检测率93.90%(277/295)，随访率97.97%(289/295)，死亡率1.69%(5/295)，失访率4.1%(12/295)。HIV母婴传播率1.06%(校正1.92%)。HIV母婴阻断及时性好率54.86%(175/319)，其影响因素包括稳定住址、妊娠意愿、确认时间、艾滋病认知、配偶支持和焦虑情绪。HIV母婴阻断依从性好率52.04%(162/319)，其影响因素包括文化程度、稳定住址、产前保健次数、病毒载量、CD4水平、艾滋病认知、配偶支持和焦虑情绪。

结论

广西贵港市等部分艾滋病高流行区HIV母婴阻断成功率比较高，但母婴阻断及时性及依从性差，服务利用质量有待提高。

Abstract

Objective

To systematically evaluate the effect of the interventions for preventing mother-to-child HIV transmission and explore the factors affecting the timeliness of these interventions and the patient compliance in regions with a high HIV/AIDS prevalence in Guangxi Zhuang Autonomous Region.

Methods

Between January

2011 and September

2017

using a non-probability cluster sampling method with follow-up observation

we conducted interventions for preventing mother-to-child HIV transmission in 319 HIV-infected pregnant women in some regions with a high HIV/AIDS prevalence in Guangxi Zhuang Autonomous Region. The transmission rate

timeliness of administration and compliance with the interventions were assessed to evaluate the effect of these interventions

and a logistic regression model was used to analyze the factors influencing the timeliness of the interventions and the patient compliance.

Results

The rate of antiviral drug administration was 95.92% (306/319) in these HIV-infected pregnant women who chose to continue pregnancy. The overall safe delivery rate was 70.51% (225/319)

and the annual safe delivery rate tended to increase with time (Z=2.03

=0.042). A total of 295 live births were recorded

and 98.31% (290/295) of the children were given antiviral drugs; the artificial feeding rate was 98.64% (291/295) in these children; 96.20% (152/158) of the children received services for early diagnosis and 93.90% (277/295) were detected for HIV antibody at 18 month. The follow-up rate of the children was 97.97% (289/295)

with a mortality rate of 1.69% (5/295) and a loss to follow-up rate of 4.1% (12/295). The mother-to-child HIV transmission rate was 1.06% (1.92% after correction) in these cases. The rate of optimal timing of the transmission-preventing interventions was 54.86% (175/319)

and the factors influencing the timeliness of the interventions included stability of address

pregnancy intention

confirmation time

AIDS awareness

spouse support and anxiety. The good compliance rate with the interventions was 52.04% (162/319)

and was influenced by the factors including the level of education

stability of address

frequency of antenatal care

viral load

CD4 level

AIDS awareness

spouse support and anxiety.

Conclusion

In these selected regions with a high HIV/AIDS prevalence

the interventions for preventing mother-to-child HIV transmission resulted in a relatively high success rate

but the timeliness of administration and compliance with these interventions

along with the quality of service utilization

remain to be improved.

关键词

Keywords

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