骨髓基质细胞CD105在异基因造血干细胞移植后植入不良与良好的表达差异

刘思恒; 冉岑霞; 易小翠; 李佳; 彭贤贵; 刘耀

doi:10.16016/j.1000-5404.201803059

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骨髓基质细胞CD105在异基因造血干细胞移植后植入不良与良好的表达差异

临床医学 | 更新时间：2026-01-09

- 骨髓基质细胞CD105在异基因造血干细胞移植后植入不良与良好的表达差异
- Expression differences of CD105 in recipient bone marrow stromal cells between patients with good and poor graft function after allogeneic hematopoietic stem cell transplantation
- 第三军医大学学报 2018年40卷第17期页码：1568-1573
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金面上项目(81670100);国家自然科学基金面上项目(81370594)
- DOI：10.16016/j.1000-5404.201803059
  中图分类号：
- 收稿：2018-03-08，
  
  纸质出版：2018-09-15
- 稿件说明：
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刘思恒, 冉岑霞, 易小翠, 等. 骨髓基质细胞CD105在异基因造血干细胞移植后植入不良与良好的表达差异[J]. 第三军医大学学报, 2018,40(17):1568-1573.

Siheng LIU, Cenxia RAN, Xiaocui YI, et al. Expression differences of CD105 in recipient bone marrow stromal cells between patients with good and poor graft function after allogeneic hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2018, 40(17): 1568-1573.
刘思恒, 冉岑霞, 易小翠, 等. 骨髓基质细胞CD105在异基因造血干细胞移植后植入不良与良好的表达差异[J]. 第三军医大学学报, 2018,40(17):1568-1573. DOI： 10.16016/j.1000-5404.201803059.

Siheng LIU, Cenxia RAN, Xiaocui YI, et al. Expression differences of CD105 in recipient bone marrow stromal cells between patients with good and poor graft function after allogeneic hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2018, 40(17): 1568-1573. DOI： 10.16016/j.1000-5404.201803059.

摘要

Abstract

Objective

To investigate the expression profiles of adhesion molecule-related antigens in bone marrow stromal cells of the recipients with good and poor graft function after allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods

A total of 118 patients underwent allo-HSCT in our department in 2016 were recruited in this study. According to the functional status of the graft after allo-HSCT

the recipients were divided into good graft function (GGF) group and poor graft function (PGF) for comparison of age

primary disease

stem cell source

HLA typing

gender matching

ABO blood group matching

bone marrow hyperplasia before transplantation

recurrence rates

and mortality rates. For 28 recipients with PGF and 27 with GGF

the pre-transplant bone marrow biopsy specimens were obtained for immunohistochemical analysis of the adhesion molecules including CD44

CD105

CD29

intercellular adhesion molecule-1 (ICAM-1)

and vascular cell adhesion molecule-1 (VCAM-1).

Results

The recipients with PGF and GGF did not show significant differences in age

primary disease

stem cell source

HLA typing

gender matching

ABO blood group matching or the degree of bone marrow hyperplasia before transplantation (

0.05). Compared with those with GGF

the recipients with PGF had a significantly higher CMV infection rate after transplantation and a significantly lower remission rate before transplantation (

0.05). Cox regression analysis showed that the recipients with PGF following allo-HSCT had a significantly lower survival rate than those with GGF (

0.05

=3.598). The expression levels of CD44

CD29

ICAM-1 and VCAM-1 in recipient bone marrow stromal cells were comparable between the recipients with GGF and PGF (

0.05)

but the recipients with PGF following allo-HSCT had a significantly higher expression level of CD105 in the stromal cells than those with GGF (

0.05).

Conclusion

PGF following allo-HSCT is associated with a significantly decreased survival rate of the recipients. The occurrence of PGF following allo-HSCT is probably linked with an increased expression of CD105 in the bone marrow stromal cells of the recipients before transplantation.

关键词

Keywords

references

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