不同剂量纳布啡联合芬太尼对腹腔镜子宫肌瘤挖除术患者术后镇痛的效果分析

颜娅; 何才; 戴珩; 罗密; 李有长

doi:10.16016/j.1000-5404.201803043

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不同剂量纳布啡联合芬太尼对腹腔镜子宫肌瘤挖除术患者术后镇痛的效果分析

临床医学 | 更新时间：2026-01-09

- 不同剂量纳布啡联合芬太尼对腹腔镜子宫肌瘤挖除术患者术后镇痛的效果分析
- Analgesic effect of different doses of nalbuphine combined with fentanyl by patient-controlled intravenous analgesia for patients after laparoscopic myomectomy
- 第三军医大学学报 2018年40卷第17期页码：1595-1598
- 作者机构：
- 作者简介：
- 基金信息：
  
  重庆市渝中区科学技术委员会指导性项目(20170156)
- DOI：10.16016/j.1000-5404.201803043
  中图分类号：
- 收稿：2018-03-06，
  
  纸质出版：2018-09-15
- 稿件说明：
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颜娅, 何才, 戴珩, 等. 不同剂量纳布啡联合芬太尼对腹腔镜子宫肌瘤挖除术患者术后镇痛的效果分析[J]. 第三军医大学学报, 2018,40(17):1595-1598.

Ya YAN, Cai HE, Heng DAI, et al. Analgesic effect of different doses of nalbuphine combined with fentanyl by patient-controlled intravenous analgesia for patients after laparoscopic myomectomy[J]. Journal of Third Military Medical University, 2018, 40(17): 1595-1598.
颜娅, 何才, 戴珩, 等. 不同剂量纳布啡联合芬太尼对腹腔镜子宫肌瘤挖除术患者术后镇痛的效果分析[J]. 第三军医大学学报, 2018,40(17):1595-1598. DOI： 10.16016/j.1000-5404.201803043.

Ya YAN, Cai HE, Heng DAI, et al. Analgesic effect of different doses of nalbuphine combined with fentanyl by patient-controlled intravenous analgesia for patients after laparoscopic myomectomy[J]. Journal of Third Military Medical University, 2018, 40(17): 1595-1598. DOI： 10.16016/j.1000-5404.201803043.

摘要

Abstract

Objective

To investigate the analgesic effect and optimum dose of nalbuphine combined with fentanyl prepared for patient-controlled intravenous analgesia (PCIA) after laparoscopic myomectomy.

Methods

One hundred and sixty patients who had arranged PCIA after laparoscopic myomectomy in our hospital between July and December 2017 were randomly divided into 4 groups (

=40): 40 mg nalbuphine group (N1)

60 mg nalbuphine group (N2)

80 mg nalbuphine group (N3) and 1 000 mg tramadol group (Q). The analgesic agents were respectively diluted with 0.2 mg fentanyl

8 mg ondansetron and 10 mg dexamethasone together to 100 mL with normal saline for PCIA in each group. Ramsay sedation score

visual analog scale (VAS) score at 6

24 and 48 h after surgery

ratio of those needing rescue analgesia

and adverse events were observed.

Results

The VAS scores at different time points and the ratio of those needing rescue analgesia were significantly higher in the group N1 than the other 3 groups (

0.05)

but there was no significant difference among th

e 3 groups (

0.05). The N3 group had the highest Ramsay sedation score and increased incidence of somnolence (

0.05)

and the Q group had higher incidences of nausea and vomiting after operation (

0.05).

Conclusion

Nalbuphine of 60 mg combined with 0.2 mg fentanyl exerts satisfactory analgesic effect and has less adverse events for PCIA after laparoscopic myomectomy.

关键词

Keywords

references

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