体外膜肺氧合技术在心死亡供体肝脏维护中的应用

欧晏娇; 邓永; 刘炜; 张世新; 张雷达

doi:10.16016/j.1000-5404.201802130

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体外膜肺氧合技术在心死亡供体肝脏维护中的应用

临床医学 | 更新时间：2026-01-09

- 体外膜肺氧合技术在心死亡供体肝脏维护中的应用
- Application of extracorporeal membrane oxygenation in maintenance of liver for donation after cardiac death
- 第三军医大学学报 2018年40卷第17期页码：1574-1578
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201802130
  中图分类号：
- 收稿：2018-02-25，
  
  纸质出版：2018-09-15
- 稿件说明：
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欧晏娇, 邓永, 刘炜, 等. 体外膜肺氧合技术在心死亡供体肝脏维护中的应用[J]. 第三军医大学学报, 2018,40(17):1574-1578.

Yanjiao OU, Yong DENG, Wei LIU, et al. Application of extracorporeal membrane oxygenation in maintenance of liver for donation after cardiac death[J]. Journal of Third Military Medical University, 2018, 40(17): 1574-1578.
欧晏娇, 邓永, 刘炜, 等. 体外膜肺氧合技术在心死亡供体肝脏维护中的应用[J]. 第三军医大学学报, 2018,40(17):1574-1578. DOI： 10.16016/j.1000-5404.201802130.

Yanjiao OU, Yong DENG, Wei LIU, et al. Application of extracorporeal membrane oxygenation in maintenance of liver for donation after cardiac death[J]. Journal of Third Military Medical University, 2018, 40(17): 1574-1578. DOI： 10.16016/j.1000-5404.201802130.

摘要

Abstract

Objective

To explore the application of extracorporeal membrane oxygenation (ECMO) in the maintenance of the liver for donation after cardiac death.

Methods

The liver organs from 36 donors after heart death were protected by different ways in our hospital from September 2014 to January 2018. They were divided into 2 groups: ECMO protection group (ECMO group) and non-ECMO protection group (non-ECMO group). The donor liver organs were evaluated and maintained for the stability of the donor environment by actively rectifying the acid for acid-base homeostasis

and the liver was given protective agents when the liver function was abnormal before the donor liver organs were protected. In the course of donor maintenance treatment

the donors of the ECMO group underwent ECMO technology to get maintenance. For the doors of the non-ECMO group

life support was removed in time

and the donor liver was obtained in 5 min after cardiac arrest. The pathology of donor liver before transplantation

incidence rates of primary nonfunction after liver transplantation

ischemic biliary tract disease and acute rejection

and the liver function after transplantation were observed and compared between the 2 groups.

Results

Significant difference was seen in the hepatocyte necrosis (

=0.026)

but no such differences in hepatocyte fatty degeneration and hepatocyte degeneration (

0.05) in the livers between the ECMO group and non-ECMO group before transplantation. There were significant differences in the incidence rates of primary nonfunction after liver transplantation (

=0.045) and ischemic biliary tract disease (

=0.026) between the 2 groups. After liver transplantation

ALT

AST

TBIL

Alb and PT indicators

and liver function indexes were all decreased with time elapse

and the values of indexes were all statistically lower in the ECMO group than the other group (

0.05).

Conclusion

ECMO technique exerts good effect on the maintenance of the liver for donation after cardiac death.

关键词

Keywords

references

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