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高危型人乳头瘤病毒与鳞状细胞癌抗原对宫颈癌患者术后复发的预测价值
Predictive value of HR-HPV and SCC-Ag assessment during follow-up for recurrence of postoperative cervical cancer
- 第三军医大学学报 2018年40卷第11期 页码：1033-1037
- 作者机构：
- 作者简介：
- 基金信息：
DOI：10.16016/j.1000-5404.201802068
中图分类号：收稿：2018-02-08，
纸质出版：2018-06-15
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刘渝, 李力, 陈建昆, 等. 高危型人乳头瘤病毒与鳞状细胞癌抗原对宫颈癌患者术后复发的预测价值[J]. 第三军医大学学报, 2018,40(11):1033-1037.
Yu LIU, Li LI, Jiankun CHEN, et al. Predictive value of HR-HPV and SCC-Ag assessment during follow-up for recurrence of postoperative cervical cancer[J]. Journal of Third Military Medical University, 2018, 40(11): 1033-1037.
刘渝, 李力, 陈建昆, 等. 高危型人乳头瘤病毒与鳞状细胞癌抗原对宫颈癌患者术后复发的预测价值[J]. 第三军医大学学报, 2018,40(11):1033-1037. DOI： 10.16016/j.1000-5404.201802068.
Yu LIU, Li LI, Jiankun CHEN, et al. Predictive value of HR-HPV and SCC-Ag assessment during follow-up for recurrence of postoperative cervical cancer[J]. Journal of Third Military Medical University, 2018, 40(11): 1033-1037. DOI： 10.16016/j.1000-5404.201802068.
摘要
Abstract
Objective
2
To explore the value of predicting recurrence of postoperative cervical cancer by monitoring high-risk human papilloma virus (HR-HPV) and squamous cell carcinoma antigen (SCC-Ag) during following-up.
Methods
2
A total of 406 women who underwent radical or subtotal hysterectomy
or cervical conization or radical trachelectomy due to cervical cancer in our department from January 2012 to December 2016 were prospectively enrolled in this study. During the routine follow-up
HR-HPV and SCC-Ag assessment was performed. The relationship of recurrence with HR-HPV and SCC-Ag was analyzed
and the differences of single detection and joint detection were compared in the prediction of recurrence.
Results
2
Compared those unrecurrent patients
those recurrent had higher HR-HPV persistent
positive rate (
P
<
0.001)
and higher positive rate of SCC-Ag (
P
<
0.001). The patients with pelvic recurrence had a higher persistent positive rate of HR-HPV than those with distant metastasis (
P
<
0.05)
but no such difference was seen in the positive rate of SCC-Ag between those with recurrence and with distant metastasis (
P
>
0.05). In the prediction of recurrence of cervical cancer
single detection of HR-HPV had higher sensitivity (57.9%)
and single detection of SCC-Ag showed higher specificity (95.1%)(both
P
<
0.05). Whereas
joint detection of HR-HPV and SCC-Ag obtained higher sensitivity (76.3%) than single detection (
P
<
0.05).
Conclusion
2
Assessment of HR-HPV and SCC-Ag during following-up can warn the recurrence of cervical cancer in a certain extent
and joint detection can improve the sensitivity of prediction.
关键词
Keywords
references
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