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基于太赫兹波谱差异的脑胶质瘤术中原位识别技术研究
Intraoperative
in situ recognition of brain glioma in mice based on terahertz spectroscopy- 第三军医大学学报 2018年40卷第16期 页码：1444-1449
- 作者机构：
- 作者简介：
- 基金信息：国家重点基础研究发展计划项目(2015CB755400);国家十二五科技支撑计划(2015BAI01B01);西南医院联合孵化项目(SWH2016LHJC-01)
DOI：10.16016/j.1000-5404.201802067
中图分类号：收稿：2018-02-08，
纸质出版：2018-08-30
- 稿件说明：
移动端阅览
陈图南, 李江, 王与烨, 等. 基于太赫兹波谱差异的脑胶质瘤术中原位识别技术研究[J]. 第三军医大学学报, 2018,40(16):1444-1449.
Tunan CHEN, Jiang LI, Yuye WANG, et al. Intraoperative
in situ recognition of brain glioma in mice based on terahertz spectroscopy[J]. Journal of Third Military Medical University, 2018, 40(16): 1444-1449.陈图南, 李江, 王与烨, 等. 基于太赫兹波谱差异的脑胶质瘤术中原位识别技术研究[J]. 第三军医大学学报, 2018,40(16):1444-1449. DOI： 10.16016/j.1000-5404.201802067.
Tunan CHEN, Jiang LI, Yuye WANG, et al. Intraoperative
in situ recognition of brain glioma in mice based on terahertz spectroscopy[J]. Journal of Third Military Medical University, 2018, 40(16): 1444-1449. DOI： 10.16016/j.1000-5404.201802067.
摘要
Abstract
Objective
2
To explore the technical feasibility of intraoperative positioning and qualitative diagnosis of brain gliomas using terahertz spectroscopy.
Method
2
At an air humidity of 10%
a reflective full-fiber terahertz time-domain spectrum system was used to obtain terahertz time-domain pulse signals of mouse brain
gliomas and normal brain tissues on the surface of the cerebral hemisphere.The spectral parameters of the gliomas and normal brain tissues were extracted and analyzed for their differences for
in situ
recognition of the tumors.
Results
2
Normal mouse brain tissues and brain gliomas showed significantly different refractivity within the range of 0.4 to 0.6 THz and significantly different absorption coefficients within the range of 0.4 to 0.9 THz.The tumor and normal brain tissues could be effectively recognized and positioned based on the differences of the parameters of terahertz spectroscopy.
Conclusion
2
Our preliminary findings verify the possibility of using terahertz spectroscopy for intraoperative
in situ
recognition of gliomas to provide assistance in precision tumor resection.
关键词
Keywords
references
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