
浏览全部资源
扫码关注微信
400037 重庆,陆军军医大学(第三军医大学)第二附属医院泌尿外科Department of Urology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China
收稿:2017-12-22,
纸质出版:2018-02-28
移动端阅览
李龙坤, 杨振兴. 尿源性干细胞的特性及其在泌尿系统疾病治疗中的应用进展[J]. 第三军医大学学报, 2018,40(4):277-281.
Longkun LI, Zhenxing YANG. Characteristics and Application of urine-derived stem cells in treatment of urological diseases[J]. Journal of Third Military Medical University, 2018, 40(4): 277-281.
李龙坤, 杨振兴. 尿源性干细胞的特性及其在泌尿系统疾病治疗中的应用进展[J]. 第三军医大学学报, 2018,40(4):277-281. DOI: 10.16016/j.1000-5404.201712215.
Longkun LI, Zhenxing YANG. Characteristics and Application of urine-derived stem cells in treatment of urological diseases[J]. Journal of Third Military Medical University, 2018, 40(4): 277-281. DOI: 10.16016/j.1000-5404.201712215.
Urine-derived stem cells (hUSCs) are stem cells isolated from adult urine with proliferation and differentiation potentials. With much convenience to obtain in a minimally invasive manner and virtually no immunogenicity
these cells can be widely used in regenerative medicine and tissue engineering. In recent years
increasing studies were reported to use hUSCs in repairing urinary tract injury with favorable outcomes
demonstrating bright prospects for clinical application of these cells. Herein we review the current progress in the application of USCs in models of urinary system disease and assess the potentials and therapeutic mechanisms of these cells.
LE BLANC K, RASMUSSON I, SUNDBERG B, et al . Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells[J ] . Lancet, 2004, 363(9419): 1439-1441. DOI: 10.1016/S0140-6736(04)16104-7.
WU Y, CHEN L, SCOTT P G, et al . Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis[J ] . Stem Cells, 2007, 25(10): 2648-2659. DOI: 10.1634/stemcells.2007-0226.
ZHANG Y, MCNEILL E, TIAN H, et al . Urine derived cells are a potential source for urological tissue reconstruction[J ] . J Urol, 2008, 180(5): 2226-2233. DOI: 10.1016/j.juro.2008.07.023.
QIN D, LONG T, DENG J, et al . Urine-derived stem cells for potential use in bladder repair[J ] . Stem Cell Res Ther, 2014, 5(3): 69. DOI: 10.1186/scrt458.
DONG X, ZHANG T, LIU Q, et al . Beneficial effects of urine-derived stem cells on fibrosis and apoptosis of myocardial, glomerular and bladder cells[J ] . Mol Cell Endocrinol, 2016, 427: 21-32. DOI: 10.1016/j.mce.2016.03.001.
LI J, LUO H, DONG X, et al . Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model[J ] . Stem Cell Res Ther, 2017, 8(1): 107. DOI: 10.1186/s13287-017-0547-9.
LI L, ZHANG D, LI P, et al . Virus integration and genome influence in approaches to stem cell based therapy for andro-urology[J ] . Adv Drug Deliv Rev, 2015, 82-83: 12-21. DOI: 10.1016/j.addr.2014.10.012.
张腾, 董兴有, 刘骞, 等.尿源干细胞促进脊髓损伤后神经源性膀胱恢复[J].第三军医大学学报, 2016, 38(10): 1073-1077. DOI: 10.16016/j.1000-5404.201512060.
ZHANG T, DONG X Y, LIU Q, et al . Effect of urine-derived stem cell transplantation on recovery of neurogenic bladder in rats after spinal cord injury[J ] . J Third Mil Med Univ, 2016, 38(10): 1073-1077. DOI: 10.16016/j.1000-5404.201512060.
SCHOSSERER M, REYNOSO R, WALLY V, et al . Urine is a novel source of autologous mesenchymal stem cells for patients with epidermolysis bullosa[J ] . BMC Res Notes, 2015, 8: 767. DOI: 10.1186/s13104-015-1686-7.
GAO P, HAN P, JIANG D, et al . Effects of the donor age on proliferation, senescence and osteogenic capacity of human urine-derived stem cells[J ] . Cytotechnology, 2017, 69(5): 751-763. DOI: 10. 1007/s10616-017-0084-5.
CHUN S Y, KIM H T, LEE J S, et al . Characterization of urine-derived cells from upper urinary tract in patients with bladder cancer[J ] . Urology, 2012, 79(5): 1186-1181. DOI: 10.1016/j.urology.2011. 12.034.
LANG R, LIU G, SHI Y, et al . Self-renewal and differentiation capacity of urine-derived stem cells after urine p reservation for 24 hours[J ] . PLoS ONE, 2013, 8(1): e53980. DOI: 10.1371/journal.pone.0053980.
HE W, ZHU W, CAO Q, et al . Generation of mesenchymal-like stem cells from urine in pediatric patients[J ] . Transplant Proc, 2016, 48(6): 2181-2185. DOI: 10.1016/j.transproceed.2016.02. 078.
FLORES I, CAYUELA M L, BLASCO M A. Effects of telomerase and telomere length on epidermal stem cell behavior[J]. Science, 2005, 309(5738): 1253-1256. DOI: 10.1126/science.1115025.
BHARADWAJ S, LIU G, SHI Y, et al . Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology[J ] . Stem Cells, 2013, 31(9): 1840-1856. DOI: 10.1002/stem.1424.
GUAN J J, NIU X, GONG F X, et al . Biological characteristics of human-urine-derived stem cells: potential for cell-based therapy in neurology[J ] . Tissue Eng Part A, 2014, 20(13-14): 1794-1806. DOI: 10.1089/ten.TEA.2013.0584.
KANG H S, CHOI S H, KIM B S, et al . Advanced properties of urine derived stem cells compared to adipose tissue derived stem cells in terms of cell proliferation, immune modulation and multi differentiation[J ] . J Korean Med Sci, 2015, 30(12): 1764-1776. DOI: 10.3346/jkms.2015.30.12.1764.
QIN H, ZHU C, AN Z, et al . Silver nanoparticles promote osteogenic diffe rentiation of human urine-derived stem cells at noncytotoxic concentrations[J ] . Int J Nanomedicine, 2014, 9: 2469-2478. DOI: 10.2147/IJN.S59753.
GUAN J, ZHANG J, GUO S, et al . Human urine-derived stem cells can be induced into osteogenic lineage by silicate bioceramics via activation of the Wnt/β-catenin signaling pathway[J ] . Biomaterials, 2015, 55: 1-11. DOI: 10.1016/j.biomaterials.2015.03.029.
GUAN J, ZHANG J, ZHU Z, et al . Bone morphogenetic protein 2 gene transduction enhances the osteogenic potential of human urine-derived stem cells[J ] . Stem Cell Res Ther, 2015, 6: 5. DOI: 10.1186/scrt539.
XUE Y, CAI X, WANG L, et al . Generating a non-integrating human induced pluripotent stem cell bank from urine-derived cells[J ] . PLoS ONE, 2013, 8(8): e70573. DOI: 10.1371/journal.pone. 0070573.
CHEN Y, LUO R, XU Y, et al . Generation of systemic lupus erythematosus-specific induced pluripotent stem cells from urine[J ] . Rheumatol Int, 2013, 33(8): 2127-2134. DOI: 10.1007/s00296-013-2704-5.
ZHOU J, WANG X, ZHANG S, et al . Generation and characterization of human cryptorchid-specific induced pluripotent stem cells from urine[J ] . Stem Cells Dev, 2013, 22(5): 717-725. DOI: 10.1089/scd.2012.0260.
GUAN X, MACK D L, MORENO C M, et al . Dystrop hin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery[J ] . Stem Cell Res, 2014, 12(2): 467-480. DOI: 10.1016/j.scr.2013.12.004.
JOUNI M, SI-TAYEB K, ES-SALAH-LAMOUREUX Z, et al . Toward personalized medicine: using cardiomyocytes differentiated from urine-derived pluripotent stem cells to recapitulate electrophysiological characteristics of type 2 long QT syndrome[J ] . J Am Heart Assoc, 2015, 4(9): e002159. DOI: 10.1161/JAHA.115.002159.
WANG C, HEI F, JU Z, et al . Differentiation of urine-derived human induced pluripotent stem cells to alveolar type Ⅱ epithelial cells[J ] . Cell Reprogram, 2016, 18(1): 30-36. DOI: 10.1089/cell.2015.0015.
M LEE Y, ZAMPIERI B L, SCOTT-MCKEAN J J, et al . Generation of integration-free induced pluripotent stem cells from urine-derived cells isolated from individuals with down syndrome[J ] . Stem Cells Transl Med, 2017, 6(6): 1465-1476. DOI: 10.1002/sctm.16-0128.
MIZUTANI E, TORIKAI K, WAKAYAMA S, et al . Gene-ration of cloned mice and nuclear transfer embryonic stem cell lines from urine-derived cells[J ] . Sci Rep, 2016, 6: 23808. DOI: 10.1038/srep23808.
BODIN A, BHARADWAJ S, WU S, et al . Tissue-engineered conduit using urine-derived stem cells seeded bacterial cellulose polymer in urinary reconstruction and diversion[J ] . Biomaterials, 2010, 31(34): 8889-8901. DOI: 10.1016/j.biomaterials.2010.0 7.108.
WU S, LIU Y, BHARADWAJ S, et al . Human urine-derived stem cells seeded in a modified 3D porous small intestinal submucosa scaffold for urethral tissue engineering[J ] . Biomaterials, 2011, 32(5): 1317-1326. DOI: 10.1016/j.biomaterials. 2010.10.006.
LIU G, WANG X, SUN X, et al . The effect of urine-derived stem cells expressing VEGF loaded in collagen hydrogels on myogenesis and innervation following after subcutaneous implantation in nude mice[J ] . Biomaterials, 2013, 34(34): 8617-8629. DOI: 10.1016/j.biomaterials.2013. 07.077.
FU Y, GUAN J, GUO S, et al . Human urine-derived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis[J ] . J Transl Med, 2014, 12: 274. DOI: 10.1186/s12967-014-0274-2.
TIAN S F, JIANG Z Z, LIU Y M, et al . Human urine-derived stem cells contribute to the repair of ischemic acute kidney injury in rats[J ] . Mol Med Rep, 2017, 16(4): 5541-5548. DOI: 10.3892/mmr.2017.7240.
AICHER W K, HART M L, STALLKAMP J, et al . Towards a treatment of stress urinary incontinence: Application of mesenchymal stromal cells for regeneration of the sphincter muscle[J ] . J Clin Med, 2014, 3(1): 197-215. DOI: 10.3390/jcm3010197.
OUYANG B, SUN X, HAN D, et al . Human urine-derived stem cells alone or genetically-modified with FGF2 improve type 2 diabetic erectile dysfunction in a rat model[J ] . PLoS ONE, 2014, 9(3): e92825. DOI: 10.1371/journal.pone.0092825.
LEE J N, CHUN S Y, LEE H J, et al . Human urine-derived stem cells seeded surface modified composite scaffold grafts for bladder reconstruction in a rat model[J ] . J Korean Med Sci, 2015, 30(12): 1754-1763. DOI: 10.3346/jkms. 2015.30.12.1754.
JIANG Z Z, LIU Y M, NIU X, et al . Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type Ⅰ diabetes in rats[J ] . Stem Cell Res Ther, 2016, 7: 24. DOI: 10.1186/s13287-016-0287-2.
0
浏览量
0
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621