血浆血红素加氧酶1和基质金属蛋白酶9与冠心病的相关性分析

刘晶晶; 井立省; 王军

doi:10.16016/j.1000-5404.201712054

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血浆血红素加氧酶1和基质金属蛋白酶9与冠心病的相关性分析

临床医学 | 更新时间：2026-01-09

- 血浆血红素加氧酶1和基质金属蛋白酶9与冠心病的相关性分析
- Correlation of plasma heme oxygenase-1 and matrix metalloproteinase-9 with coronary artery disease
- 第三军医大学学报 2018年40卷第13期页码：1247-1250
- 作者机构：
  
  102300 北京，北京市门头沟区医院心内科
- 作者简介：
  
  [井立省，E-mail：jinglisheng_2004@163.com JING Lisheng, E-mail:jinglisheng_2004@163.com
- 基金信息：
- DOI：10.16016/j.1000-5404.201712054
  中图分类号： R345;R446.112;R541.4
- 收稿：2017-12-01，
  
  修回：2018-01-05，
  
  纸质出版：2018-07-15
- 稿件说明：
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刘晶晶, 井立省, 王军. 血浆血红素加氧酶1和基质金属蛋白酶9与冠心病的相关性分析[J]. 第三军医大学学报, 2018,40(13):1247-1250.

Jingjing LIU, Lisheng JING, Jun WANG. Correlation of plasma heme oxygenase-1 and matrix metalloproteinase-9 with coronary artery disease[J]. Journal of Third Military Medical University, 2018, 40(13): 1247-1250.
刘晶晶, 井立省, 王军. 血浆血红素加氧酶1和基质金属蛋白酶9与冠心病的相关性分析[J]. 第三军医大学学报, 2018,40(13):1247-1250. DOI： 10.16016/j.1000-5404.201712054.

Jingjing LIU, Lisheng JING, Jun WANG. Correlation of plasma heme oxygenase-1 and matrix metalloproteinase-9 with coronary artery disease[J]. Journal of Third Military Medical University, 2018, 40(13): 1247-1250. DOI： 10.16016/j.1000-5404.201712054.

摘要

目的

探讨血浆血红素加氧酶1(heme oxygenase-1 HO-1)和血浆基质金属蛋白酶9(matrix metalloproteinase-9，MMP-9)与冠心病的相关性。

方法

选择2011年3月至2014年12月在北京市门头沟区医院心内科疑似冠心病的住院患者292例，其中男性167例，女性125例；年龄34~90(64±12)岁。根据冠脉造影(coronary angiography，CAG)结果分为对照组(143例)和冠心病组(149例)，冠心病组根据病变支数又分为单支病变(38例)、双支病变(46例)、多支病变(65例)，测量患者HO-1及MMP-9水平，计算冠心病组Gensini积分；同时收集病史、尿酸、血脂、高敏C反应蛋白、糖化血红蛋白等指标，评价HO-1、MMP-9与冠心病的相关性。

结果

① 冠心病组MMP-9及Gensini积分明显高于对照组(

＜0.05)，HO-1水平明显低于对照组(

＜0.05)；②MMP-9及Gensini积分随着病变血管数增加而升高(

＜0.05)，HO-Ⅰ水平则降低(

＜0.05)；③HO-1与Gensini积分呈负相关(

=-0.952，

＜0.01)，MMP-9与Gensini积分呈正相关(

=0.881，

＜0.01)，HO-1与MMP-9呈负相关(

=-0.818，

＜0.01)。

结论

血浆中HO-1和MMP-9水平与冠心病有关。

Abstract

Objective

To investigate the correlation of heme oxygenase-1 (HO-1) and matrix metalloproteinase-9 (MMP-9) with coronary artery disease (CAD).

Methods

A prospective cohort study was carried out on 292 inpatients (167 males and 125 females

at a mean age of 64±12 years

ranging from 34 to 90 years) with suspected CAD admitted in our department during March 2011 and December 2014. According to the results of coronary angiography (CAG)

the patients were divided into control group (

=143) and CAD group (

=149). According to the number of vessels involved

the patients of CAD group was further divided into one-vessel subgroup (

=38)

two-vessel subgroup (

=46)

and multi-vessel subgroup (

=65). The plasma levels of HO-1 and MMP-9 were measured in all the patients

their medical history was colle

cted

and the results of uric acid

blood lipids

high sensitivity C-reactive protein (Hs-CRP)

glycosylated hemoglobin were recorded. Gensini's score was calculated in the CAD group. The correlations of HO-1 and MMP-9 with CAD were analyzed.

Results

① The MPV level and Gensini's score in the CAD group were obviously higher than those in the control group (

0.05)

while the level of HO-1 was significantly lower (

0.05). ② With more vessels involved

the MMP-9 level and Gensini's score were significantly increased (

0.05)

while the HO-1 level was notably decreased (

0.05). ③ The level of HO-1 was negatively correlated with Gensini's score (

=-0.952

0.01)

while that of MMP-9 was positively (

=0.881

0.01). Furthermore

the levels of the 2 indicators were negatively correlated (

=－0.818

0.01).

Conclusion

Plasma HO-1 and MMP-9 levels are associated with CAD.

关键词

Keywords

references

何海英.幽门螺杆菌感染对冠心病患者冠状动脉狭窄与血清同型半胱氨酸的影响[J].中华医院感染学杂志, 2012, 22(6):1210-1212.

HE H Y. Influence of Helicobacter pylori infection on coronary artery stenosis and serum homocysteine in patients with coronary heart diseases[J]. Chin J Nosocomial, 2012, 22(6):1210-1212.

靳霄涵, 徐忠伟, 李玉明.血红素氧合酶-1与心血管系统的相关研究[J].微循环学杂志, 2016, 26(1):57-60.

QI X H, XU Z W, LI Y M. The study of HO-1 and cardiovascular system[J]. Chin J microcirc, 2016, 26(1):57-60.

李谌, 黄维义.血红素氧合酶1的生物学特性及其在冠心病防治中的作用[J].中国动脉硬化杂志, 2016, 24(1):92-96.

LI Z, HUANG W Y. The biological property of heme oxygenase-1 and its preventive and therapeutically effects in coronary heart disease[J]. Chin J Arterioscler, 2016, 24(1):92-96.

万招飞, 张娇, 薛嘉虹, 等.冠心病患者动脉弹性与血清高敏C反应蛋白和基质金属蛋白酶9的相关性[J].中国动脉硬化杂志, 2012, 20(11):1003-1006.

WAN Z F, ZHANG J, XUE J H, et al. The correlation between arterial elasticity indexes and serum high sensitivity C-reactive protein and matrix metalloproteinase-9 in patients with coronary heart disease[J]. Chin J Arterioscler, 2012, 20(11):1003-1006.

杨粉娣, 郭姣.基质金属蛋白酶与动脉粥样硬化斑块稳定性的关系研究进展[J].实用医学杂志, 2011, 27(21):3981-3983.

YANG F D, GUO J. The research progress of matrix metalloproteinase and the atherosclerotic plaque stability[J]. J Pract Med, 2011, 27(21):3981-3983.

宋涛, 陈悦, 初巍巍, 等. MMP-2和MMP-9水平与急性冠脉综合征的相关性临床研究[J].临床和实验医学杂志, 2014, 13(5):407-410.

SONG T, CHEN Y, CU W W, et al.The clinical study On the correlation between MMP-2 and MMP-9 levels and acute coronary syndrome[J].J Clin Exp Med, 2014, 13(5):407-410.

YOKOYAMA K, DAIDA H. Selective coronary angiography[J]. Nippon Rinsho, 2011, 69(Suppl 7): 206-215.

WANG C Y, CHAU L Y. Heme oxygenase-1 in cardiovascular diseases: molecular mechanisms and clinical perspectives[J]. Chang Gung Med J, 2010, 33(1): 13-24.

DULAK J, DESHANE J, JOZKOWICZ A, et al. Heme oxygenase-1 and carbon monoxide in vascularpathobiology: focus on angiogenesis[J]. Circulation, 2008, 117(2): 231-241. DOI:10.1161/CIRCULATIONAHA.107.698316.

WU M L, HO Y C, YET S F. A central role of heme oxygenase-1 in cardiovascular protection[J]. Antioxid Redox Signal, 2011, 15(7): 1835-1846. DOI:10.1089/ars.2010.3726.

刘福成, 陈鲁原, 黎励文, 等.冠心病患者血浆脂联素、血红素加氧酶1与冠状动脉病变程度的相关性[J].中国动脉硬化杂志, 2010, 18(6):395-398.

LIU F C, CHEN L Y, LI L W, et al. Association between plasma APN, hemeoxygenase-1 and severity of coronary artery lesions in patients with coronary artery disease[J].Chin J Arterioscler, 2010, 18(6):395-398.

李莹, 宋耀明, 赵友光, 等.急性冠脉综合征患者血清APN、HO-1水平与冠状动脉病变严重程度的相关性研究[J].第三军医大学学报, 2011, 33(8):845-848.

LI Y, SONG Y M, ZHAO Y G, et al.Correlation study on serum adiponectin and heme oxygenase-1 levels and severity of coronary artery disease in patients with acute coronary syndrome[J]J Third Mil Med Univ, 2011, 33(8):845-848.

BUSSEL B C V, SCHOUTEN F, HENRY R M, et al. Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period[J]. Hypertension, 2011, 58(4): 588-595. DOI:10.1161/hypertensionaha.111.174557.

LOFTUS I M, NAYLOR A R, GOODALL S, et al. Increased matrix metalloproteinase-9 activity in unstable carotid plaques. A potential role in acute plaque disruption[J]. Stroke, 2000, 31(1): 40-47. DOI:10.1161/01.str.31.1.40.

JANSSENS S, VAN DE WERF F. Cardiology. acute coronary syndromes:virchow's triad revisited[J]. Blood Coagul Fibrinolysis, 2003, 14(Suppl 2):sⅡ2.

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