创伤性颅脑损伤患者脑能量代谢改变的特点与研究展望

韦博; 李朝晖

doi:10.16016/j.1000-5404.201712050

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创伤性颅脑损伤患者脑能量代谢改变的特点与研究展望

专家述评 | 更新时间：2026-01-09

- 创伤性颅脑损伤患者脑能量代谢改变的特点与研究展望
- Characteristics and research prospects of cerebral metabolism in patients with traumatic brain injury
- 第三军医大学学报 2018年40卷第13期页码：1161-1165
- 作者机构：
  
  130031 长春，吉林大学中日联谊医院神经外科
- 作者简介：
  
  [韦博，男，博士，副主任医师，副教授，担任中国研究型医院学会神经外科青委会青年委员，主持国家自然科学基金项目2项，省级科研项目3项，校级科研项目5项，获吉林省自然科技成果奖1项，以第一作者发表SCI论文25篇。主要从事复杂颅脑损伤和神经重症方面的研究。E-mail：fnhfge@sina.com WEI Bo, E-mail:fnhfge@sina.com
- 基金信息：
  
  吉林省卫生计生青年科研课题(2015Q005)
- DOI：10.16016/j.1000-5404.201712050
  中图分类号： R364.2;R651.15
- 收稿：2017-12-06，
  
  修回：2018-03-08，
  
  纸质出版：2018-07-15
- 稿件说明：
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韦博, 李朝晖. 创伤性颅脑损伤患者脑能量代谢改变的特点与研究展望[J]. 第三军医大学学报, 2018,40(13):1161-1165.

Bo WEI, Zhaohui LI. Characteristics and research prospects of cerebral metabolism in patients with traumatic brain injury[J]. Journal of Third Military Medical University, 2018, 40(13): 1161-1165.
韦博, 李朝晖. 创伤性颅脑损伤患者脑能量代谢改变的特点与研究展望[J]. 第三军医大学学报, 2018,40(13):1161-1165. DOI： 10.16016/j.1000-5404.201712050.

Bo WEI, Zhaohui LI. Characteristics and research prospects of cerebral metabolism in patients with traumatic brain injury[J]. Journal of Third Military Medical University, 2018, 40(13): 1161-1165. DOI： 10.16016/j.1000-5404.201712050.

摘要

Abstract

Cerebral metabolism failure is one of the most important pathophysiological changes after traumatic brain injury (TBI). The energy metabolism disorder following TBI is associated with failure to maintain normal ionic homeostasis

excitotoxic releases of glutamate and other excitatory neurotransmitters

free radicals damage

and mitochondrial dysfunction. There are several methods to measure cerebral metabolism

including jugular bulb catheter

cerebral microdialysis (CMD)

positron emission tomography (PET)

and magnetic resonance spectroscopy (MRS). It is of great importance to monitor cerebral metabolism in the TBI patients in order to evaluate the severity of brain injury

predict the risk for development of secondary cerebra injury

guide systemic glucose management

assess the ability of nerve repair

and so on. Monitoring cerebral metabolism has been an important part of multimodal monitoring in severe neurological patients.

关键词

Keywords

references

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