内镜黏膜下剥离术治疗食管早癌及癌前病变384例临床分析

刘姚江; 林辉; 樊超强; 于劲; 柏健鹰; 赵晓晏

doi:10.16016/j.1000-5404.201712002

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内镜黏膜下剥离术治疗食管早癌及癌前病变384例临床分析

临床医学 | 更新时间：2026-01-09

- 内镜黏膜下剥离术治疗食管早癌及癌前病变384例临床分析
- Clinical evaluation of endoscopic submucosal dissection for patients with early esophageal cancer and precancerous lesion: report of 384 cases
- 第三军医大学学报 2018年40卷第11期页码：1022-1027
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201712002
  中图分类号：
- 收稿：2017-12-01，
  
  纸质出版：2018-06-15
- 稿件说明：
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刘姚江, 林辉, 樊超强, 等. 内镜黏膜下剥离术治疗食管早癌及癌前病变384例临床分析[J]. 第三军医大学学报, 2018,40(11):1022-1027.

Yaojiang LIU, Hui LIN, Chaoqiang FAN, et al. Clinical evaluation of endoscopic submucosal dissection for patients with early esophageal cancer and precancerous lesion: report of 384 cases[J]. Journal of Third Military Medical University, 2018, 40(11): 1022-1027.
刘姚江, 林辉, 樊超强, 等. 内镜黏膜下剥离术治疗食管早癌及癌前病变384例临床分析[J]. 第三军医大学学报, 2018,40(11):1022-1027. DOI： 10.16016/j.1000-5404.201712002.

Yaojiang LIU, Hui LIN, Chaoqiang FAN, et al. Clinical evaluation of endoscopic submucosal dissection for patients with early esophageal cancer and precancerous lesion: report of 384 cases[J]. Journal of Third Military Medical University, 2018, 40(11): 1022-1027. DOI： 10.16016/j.1000-5404.201712002.

摘要

Abstract

Objective

To investigate the clinical efficacy of endoscopic submucosal dissection (ESD) for early esophageal cancer and precancerous lesions and explore its application in the treatment.

Methods

A total of 384 consecutive patients who underwent ESD due to early esophageal cancer and precancerous lesions in our endoscopic center from August 2011 to December 2016 were enrolled in this study. A retrospective analysis was performed to evaluate the efficacy of the approach.

Results

All the 384 patients with early esophageal cancer or dysplasia completed ESD

and were followed up for a median time of 26 (6~68) months. Their average dissection area was 12.0 (7.4~20.0) cm

and the mean procedure time was 40.0 (30.0~63.8) min. The overall en bloc resection rate was 98.96% (380/384)

the complete resection rate 9

6.35% (370/384)

and the histologically complete resection rate 92.45% (355/384). The incidence rate of bleeding

perforation

and esophageal stricture was 1.56% (6/384)

0.26% (1/384)

and 13.80% (53/384) respectively. Logistic regression analysis results showed that circumference of the lumen≥2/3 [

=63.370(14.579~275.448)

0.01

]

was an independent risk factor for esophageal stricture. The post-treatment 3-year overall survival rate was 96.30%

the cause specific survival rate was 100%

whereas

the local recurrence rate was 2.86% (11/384).

Conclusion

ESD is a safe and effective approach in treatment of early esophageal cancer and precancerous lesions.

关键词

Keywords

references

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