T-SPOT.TB检测对诊治结核感染相关脂膜炎患者的价值

胡然; 王萍; 陈奇权; 钟白玉; 宋志强; 郝飞

doi:10.16016/j.1000-5404.201710182

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T-SPOT.TB检测对诊治结核感染相关脂膜炎患者的价值

临床医学 | 更新时间：2026-01-09

- T-SPOT.TB检测对诊治结核感染相关脂膜炎患者的价值
- Clinical significance of T-SPOT.TB for diagnosis and treatment of tuberculosis in panniculitis patients
- 第三军医大学学报 2018年40卷第6期页码：528-531
- 作者机构：
  
  400038 重庆, 陆军军医大学(第三军医大学)第一附属医院皮肤科
- 作者简介：
  
  [ 郝飞, E-mail:haofei62@126.com HAO Fei, E-mail: haofei62@126.com
- 基金信息：
- DOI：10.16016/j.1000-5404.201710182
  中图分类号： R378.911;R446.5;R758.69
- 收稿：2017-10-25，
  
  修回：2017-11-27，
  
  纸质出版：2018-03-30
- 稿件说明：
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胡然, 王萍, 陈奇权, 等. T-SPOT.TB检测对诊治结核感染相关脂膜炎患者的价值[J]. 第三军医大学学报, 2018,40(6):528-531.

Ran HU, Ping WANG, Qiquan CHEN, et al. Clinical significance of T-SPOT.TB for diagnosis and treatment of tuberculosis in panniculitis patients[J]. Journal of Third Military Medical University, 2018, 40(6): 528-531.
胡然, 王萍, 陈奇权, 等. T-SPOT.TB检测对诊治结核感染相关脂膜炎患者的价值[J]. 第三军医大学学报, 2018,40(6):528-531. DOI： 10.16016/j.1000-5404.201710182.

Ran HU, Ping WANG, Qiquan CHEN, et al. Clinical significance of T-SPOT.TB for diagnosis and treatment of tuberculosis in panniculitis patients[J]. Journal of Third Military Medical University, 2018, 40(6): 528-531. DOI： 10.16016/j.1000-5404.201710182.

摘要

目的

探索结核感染T细胞斑点试验(T-SPOT.TB)检测用于脂膜炎患者中结核感染病因分析的价值。

方法

回顾性分析2011-2013年我院159例病理诊断为脂膜炎并进行T-SPOT.TB检测的患者的临床及组织病理资料，并对其中的92名患者进行3年的随访，31名健康人作研究对照。

结果

脂膜炎中T-SPOT.TB检查阳性率为76.1%，显著高于正常人群(9.7%，

＜0.001)；抗结核治疗患者有效率为75.3%，复发率为20.0%，其中完成6个月疗程的患者复发率显著低于3个月内停药的患者(

＜0.05)。

结论

T-SPOT.TB检测对于查找结核感染相关的脂膜炎患者有一定的价值。

Abstract

Objective

To explore the significance of T-SPOT.TB assay in the etiological analysis for panniculitis patients.

Methods

We retrospectively reviewed the clinical and histopathological features of 159 cases of panniculitis diagnosed in our hospital who underwent T-SPOT.TB assay from January 2011 to December 2013. And 92 cases of them were followed up by telephone for 3 years. Another 31 health individuals served as normal control.

Results

The overall positive rate to T-SPOT.TB assay was 76.1% in the panniculitis patients

significantly higher than that of healthy subjects (9.7%

＜0.001). The overall effective rate was 75.3% for anti-tuberculosis treatment

and the recurrence rate was 20.0%. The patients who accomplished treatment course of 6 months had obviously lower recurrent rate than those who only have in 3 months' treatment (

＜0.05).

Conclusion

T-SPOT.TB assay is valuable to detect the tuberculosis infection in panniculitis patients.

关键词

Keywords

references

REQUENA L, SáNCHEZ YUS E. Panniculitis. Part Ⅰ. Mostly septal panniculitis[J]. J Am Acad Dermatol, 2001, 45(2): 163-183. DOI: 10.1067/mjd.2001.114736.

REQUENA L, SáNCHEZ YUS E. Panniculitis. Part Ⅱ. Mostly lobular panniculitis[J]. J Am Acad Dermatol, 2001, 45(3): 325-361. DOI: 10.1067/mjd.2001.114735.

GILCHRIST H, PATTERSON J W. Erythema nodosum and erythema induratum (nodular vasculitis): diagnosis and management[J]. Dermatol Ther, 2010, 23(4): 320-327. DOI: 10.1111/j.1529-8019.2010.01332.x.

XU K, DING C, MANGAN C J, et al . Tuberculosis in China: A longitudinal predictive model of the general popula tion and recommendations for achieving WHO goals[J ] . Respirology, 2017, 22(7): 1423-1429. DOI: 10.1111/resp.13078.

HU Y, ZHAO Q, GRAVISS E A, et al . Use of the T-SPOT.TB assay to screen latent tuberculosis infection among the TB contacts in Shanghai, China[J ] . J Infect, 2012, 65(1): 39-48. DOI: 10.1016/j.jinf.2012.03.018.

刘琳, 王敬亚, 祖蓓蓓, 等. T-SPOT.TB试验对240例疑似结核患者的诊断分析[J].中华临床医师杂志(电子版), 2016, 10(3): 440-442.

LIU L, WANG J Y, ZU B B, et al . Diagnosis value of T-SPOT.TB test for 240 cases of suspected tuberculosis[J ] . Chin J Clinicians (Electronic Ed), 2016, 10(3): 440-442.

MCKEE P H, CALONJE E, GRANTER S R. 皮肤病理学: 与临床的联系[M]. 朱学骏, 孙建方, 译. 3版. 北京: 北京大学医学出版社, 2005: 341-384.

MCKEE P H, CALONJE E, GRANTER S R. Pathology of the skin: with clinical correlation[M]. ZHU X J, SUN J F, translated. 3rd ed. Beijing: Peking University Medical Press, 2005: 341-384.

肖东楼, 赵明刚, 王宇.中国结核病防治规划实施工作指南(2008年版)[M].北京:中国协和医科大学出版社, 2009.

XIAO D L, ZHAO M G, WANG Y. Guidelines for implementation of tuberculosis prevention and control plan in China (2008)[M]. Beijing: Beijing Union Medical University Press, 2009.

SCHWARTZ R A, NERVI S J. Erythema nodosum: a sign of systemic disease[J]. Am Fam Physician, 2007, 75(5): 695-700.

MERT A, KUMBASAR H, OZARAS R, et al . Erythema nodosum: an evaluation of 100 cases[J ] . Clin Exp Rheumatol, 2007, 25(4): 563-570.

WHITWORTH H S, SCOTT M, CONNELL D W, et al . IGRAs—the gateway to T cell based TB diagnosis[J ] . Methods, 2013, 61(1): 52-62. DOI: 10.1016/j.ymeth.2012.12.012.

GETAHUN H, MATTEELLI A, CHAISSON R E, et al . Latent Mycobacterium tuberculosis infection[J ] . N Engl J Med, 2015, 372(22): 2127-2135. DOI: 10.1056/NEJMra1405427.

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