运用化学交换饱和转移技术的磁共振成像方法对腰椎间盘早期退行性变的定量评估

熊宣淇; 李可; 杜明珊; 侯文静; 李静; 李莲; 欧园; 陈家飞; 谢兵; 陈伟

doi:10.16016/j.1000-5404.201710132

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运用化学交换饱和转移技术的磁共振成像方法对腰椎间盘早期退行性变的定量评估

临床医学 | 更新时间：2026-01-09

- 运用化学交换饱和转移技术的磁共振成像方法对腰椎间盘早期退行性变的定量评估
- Quantificational evaluation for early degeneration of lumbar intervertebral disc by magnetic resonance imaging based on chemical exchange saturation transfer
- 第三军医大学学报 2018年40卷第5期页码：431-436
- 作者机构：
  
  1.400038 重庆，陆军军医大学(第三军医大学)第一附属医院放射科
  2.614000 四川乐山，武警四川总队医院放射科
- 作者简介：
  
  [陈伟，E-mail: landcw@hotmail.comCHEN Wei, E-mail: landcw@hotmail.com
- 基金信息：
  
  国家重点研发计划(2016YFC1100501)
- DOI：10.16016/j.1000-5404.201710132
  中图分类号： R181.32;R445.2;R681.53
- 收稿：2017-10-19，
  
  修回：2017-12-13，
  
  纸质出版：2018-03-15
- 稿件说明：
移动端阅览
熊宣淇, 李可, 杜明珊, 等. 运用化学交换饱和转移技术的磁共振成像方法对腰椎间盘早期退行性变的定量评估[J]. 第三军医大学学报, 2018,40(5):431-436.

Xuanqi XIONG, Ke LI, Mingshan DU, et al. Quantificational evaluation for early degeneration of lumbar intervertebral disc by magnetic resonance imaging based on chemical exchange saturation transfer[J]. Journal of Third Military Medical University, 2018, 40(5): 431-436.
熊宣淇, 李可, 杜明珊, 等. 运用化学交换饱和转移技术的磁共振成像方法对腰椎间盘早期退行性变的定量评估[J]. 第三军医大学学报, 2018,40(5):431-436. DOI： 10.16016/j.1000-5404.201710132.

Xuanqi XIONG, Ke LI, Mingshan DU, et al. Quantificational evaluation for early degeneration of lumbar intervertebral disc by magnetic resonance imaging based on chemical exchange saturation transfer[J]. Journal of Third Military Medical University, 2018, 40(5): 431-436. DOI： 10.16016/j.1000-5404.201710132.

摘要

目的

探讨黏多糖化学交换饱和转移(glycosaminoglycan chemical exchange saturation transfer，gagCEST)磁共振成像在腰椎间盘退变早期、定量诊断中的价值。

方法

纳入2016年5月至2017年5月陆军军医大学第一附属医院37例年龄18~74岁有或无腰椎间盘退变的受试者，观察其L1/2~L5/S1五个椎间盘，共185个椎间盘。将185个椎间盘的T

WI按Pfirrmann分级标准，半定量地分为5级，检测其髓核与纤维环的T

*与gagCEST两个定量磁共振参数并做统计分析。

结果

腰椎间盘髓核与纤维环的T

*与gagCEST在不同退变程度之间均具有一定的组间差异性，尤其是gagCEST在正常组与早期退变组之间差异具有统计学意义(

0.05)，并且gagCEST与Pfirrmann分级显示出比T

*有更好的等级相关性(髓核：

=-0.951

0.001；纤维环：

=-0.938

0.001)。

结论

化学交换饱和转移技术的磁共振成像方法可用于对腰椎间盘退变的早期、定量诊断，也可评估椎间盘退变的程度。

Abstract

Objective

To investigate the values of magnetic resonance imaging (MRI) with glycosaminoglycan chemical exchange saturation transfer (gagCEST) for the early diagnosis and quantitative evaluation of lumbar disc degeneration.

Methods

Thirty-seven subjects (aged from 18~74 years) with or without lumbar disc degeneration admitted in the First Affiliated Hospital of Army Medical University from May 2016 to May 2017 were enrolled in this study. Their 5 discs (from L1/2 to L5/S1)

totally 185 discs were observed by using MRI with gagCEST. According to Pfirrmann classification of lumbar intervertebral disc degeneration

these discs were semi-quantitatively divided into 5 level groups. The T

* relaxation time and gagCEST value of nucleus pulposus (NP) and annulus fibrosus (AF) in the discs were measured

and then analyzed statistically.

Results

Certain differences were observed in T

* relaxation time and gagCEST value of NP and AF among the 5 level groups. There were significant differences in the above values between the normal group and mild degeneration group. In addition

the gagCEST of the discs showed better rank correlation with the degeneration levels than T

* MRI parameter (NP:

=-0.951

0.001; AF:

=-0.938

0.001).

Conclusion

MRI based on gagCEST can be used for early and quantitative diagnosis and severity assessment of lumbar disc degeneration.

关键词

Keywords

references

DEYO R A, WEINSTEIN J N. Low back pain[J]. N Engl J Med, 2001, 344(5): 363-370. DOI:10.1056/NEJM 200102013440508.

PFIRRMANN C W, METZDORF A, ZANETTI M, et al . Magnetic resonance classification of lumbar intervertebral disc degeneration[J ] . Spine, 2001, 26(17): 1873-1878. DOI:10.1097/00007632-200109010-00011.

URRUTIA J, BESA P, CAMPOS M, et al . The Pfirrmann classification of lumbar intervertebral disc degeneration: an independent inter-and intra-observer agreement assessment[J ] . Eur Spine J, 2016, 25(9): 2728-2733. DOI:10.1007/s00586-016-4438-z.

LING W, REGATTE R R, NAVON G, et al . Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST)[J ] . Proc Natl Acad Sci USA, 2008, 105(7): 2266-2270. DOI: 10.1073/pnas.0707666105..

ZHOU J, LAL B, WILSON D A, et al . Amide proton transfer (APT) contrast for imaging of brain tumors[J ] . Magn Reson Med, 2003, 50(6): 1120-1126. DOI:10.1002/mrm.10651.

FARRAR C T, BUHRMAN J S, LIU G, et al . Establishing the lysine-rich protein CEST reporter gene as a CEST MR imaging detector for oncolytic virotherapy[J ] . Radiology, 2015, 275(3): 746-754. DOI:10.1148/radiol.14140251.

DENG M, CHEN S Z, YUAN J, et al . Chemical exchange saturation transfer (CEST) MR technique for liver imaging at 3.0 tesla: an evaluation of different offset number and an after-meal and over-night-fast comparison[J ] . Mol Imaging Biol, 2016, 18(2): 274-282. DOI:10.1007/s11307-015-0887-8.

JONES C K, POLDERS D, HUA J, et al . In vivo three-dimensional whole-brain pulsed steady-state chemical exchange saturation transfer at 7 T[J ] . Magn Reson Med, 2012, 67(6): 1579-1589. DOI:10.1002/mrm.23141..

LIPSON S J, MUIR H. 1980 Volvo award in basic science. Proteoglycans in experimental intervertebral disc degeneration[J]. Spine, 1981, 6(3): 194-210. DOI:10.1097/00007632-198105000-00002.

LYONS G, EISENSTEIN S M, SWEET M B. Biochemical changes in intervertebral disc degeneration[J]. Biochim Biophys Acta, 1981, 673(4): 443-453. DOI:10.1016/0304-4165(81) 90476-1.

KIM M, CHAN Q, ANTHONY M P, et al . Assessment of glycosaminoglycan distribution in human lumbar intervertebral discs using chemical exchange saturation transfer at 3 T: feasibility and initial experience[J ] . NMR Biomed, 2011, 24(9): 1137-1144. DOI:10.1002/nbm.1671.

HANEDER S, APPRICH S R, SCHMITT B, et al . Assessment of glycosaminoglycan content in intervertebral discs using chemical exchange saturation transfer at 3.0 tesla: preliminary results in patients with low-back pain[J ] . Eur Radiol, 2013, 23(3): 861-868. DOI:10.1007/s00330-012-2660-6.

CASSINELLI E H, HALL R A, KANG J D. Biochemistry of intervertebral disc degeneration and the potential for gene therapy applications[J]. Spine J, 2001, 1(3): 205-214. DOI:10.1016/s1529-9430(01)00021-3.

WANG S Z, RUI Y F, LU J, et al . Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies[J ] . Cell Prolif, 2014, 47(5): 381-390. DOI:10.1111/cpr.12121.

URBAN J P, WINLOVE C P. Pathophysiology of the intervertebral disc and the challenges for MRI[J]. J Magn Reson Imaging, 2007, 25(2): 419-432.DOI:10.1002/jmri.20874.

DETIGER S E, HOLEWIJN R M, HOOGENDOORN R J, et al . MRI T 2 *mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model[J ] . Eur Spine J, 2015, 24(9): 1935-1943. DOI:10.1007/s00586-014-3498-1..

INSKO E K, CLAYTON D B, ELLIOTT M A. In vivo sodium MR imaging of the intervertebral disk at 4T[J ] . Acad Radiol, 2002, 9(7): 800-804. DOI:10.1016/s1076-6332(03)80350-1.

KESHARI K R, ZEKTZER A S, SWANSON M G, et al . Characterization of intervertebral disc degeneration by high-resolution magic angle spinning (HR-MAS) spectroscopy[J ] . Magn Reson Med, 2005, 53(3): 519-527. DOI:10.1002/mrm.20392.

ANTONIOU J, DEMERS C N, BEAUDOIN G, et al . Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity[J ] . Magn Reson Imaging, 2004, 22(7): 963-972. DOI: 10.1016/j.mri.2004.02.011.

WANG Y X, ZHAO F, GRIFFITH J F, et al . T1rho and T 2 relaxation times for lumbar disc degeneration : an in vivo comparative study at 3.0-Tesla MRI[J ] . Eur Radiol, 2013, 23(1): 228-234. DOI:10.1007/s00330-012-2591-2..

WANG Y X, GRIFFITH J F, LEUNG J C, et al . Age related reduction of T1rho and T 2 magnetic resonance relaxation times of lumbar intervertebral disc[J ] . Quant Imaging Med Surg, 2014, 4(4): 259-264. DOI:10.3978/j.issn.2223-4292.2014.07.14..

WEI W, JIA G, FLANIGAN D, et al . Chemical exchange saturation transfer MR imaging of articular cartilage glycosaminoglycans at 3T: Accuracy of B0 Field Inhomogeneity corrections with gradient echo method[J ] . Magn Reson Imaging, 2014, 32(1): 41-47. DOI:10.1016/j.mri.2013.07.009.

MELKUS G, GRABAU M, KARAMPINOS D C, et al . Ex vivo porcine model to measure pH dependence of chemical exchange saturation transfer effect of glycosaminoglycan in the intervertebral disc[J ] . Magn Reson Med, 2014, 71(5): 1743-1749. DOI:10.1002/mrm.24838.

AKELLA S V, REGATTE R R, GOUGOUTAS A J, et al . Proteoglycan-induced changes in T1rho-relaxation of articular cartilage at 4T[J ] . Magn Reson Med, 2001, 46(3): 419-423. DOI:10.1002/mrm.1208.

SAAR G, ZHANG B, LING W, et al . Assessment of glycosaminoglycan concentration changes in the intervertebral disc via chemical exchange saturation transfer[J ] . NMR Biomed, 2012, 25(2): 255-261. DOI:10.1002/nbm.1741..

LOTZ J C, HAUGHTON V, BODEN S D, et al . New treatments and imaging strategies in degenerative disease of the intervertebral disks [J ] . Radiology, 2012, 264(1):6-19. DOI: 10.1148/radiol.12110339.

BENDTSEN M, BVNGER C E, ZOU X, et al . Autologous stem cell therapy maintains vertebral blood flow and contrast diffusion through the endplate in experimental intervertebral disc degeneration[J ] . Spine, 2011, 36(6): E373-E379. DOI:10.1097/BRS.0b013e3181dce34c.

ALLEGRI M, MONTELLA S, SALICI F, et al . Mechanisms of low back pain: a guide for diagnosis and therapy [J ] . F1000Res, 2016, 5: 1530.DOI:10.12688/f1000research.8105.2.

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